The invention belongs to the technical field of aviation and particularly provides a connection structure between a central wing and a fuselage. In the connection structure a sectional bolt (1) is matched with a suspended nut (7) respectively through an aerofoil girder (2), a wing lower panel (3), an adjustment pad plate (4), a fuselage reinforcing frame (5) and a tapered washer (6). The structure solves a sealing problem in sealing zones, greatly improves assembly technology and meanwhile improves fatigue life and safety of high-stress part connection structures.