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发明授权
CN105085472B β-氯-α，β-不饱和-1,3-二噻烷类化合物的制备方法及应用 失效 - 权利终止

β-氯-α，β-不饱和-1,3-二噻烷类化合物的制备方法及应用
摘要：
本发明提供了一种β‑氯‑α，β‑不饱和‑1,3‑二噻烷类化合物的制备方法及应用。其制备方法包括以下步骤：在反应瓶中加入溶剂，2‑氯‑1，3‑二噻烷和炔烃类化合物，碘或二叔丁基过氧化物，一定温度反应完全后分离纯化即可得到相应的β‑氯‑α，β‑不饱和‑1,3‑二噻烷化合物。本发明以廉价易得的原料，通过简单的混合与搅拌，高效实现了β‑氯‑α，β‑不饱和‑1,3‑二噻烷类化合物的制备。该方法反应条件温和，收率高，并具有环境友好，原子经济等优点。该类化合物能够用于多种有用化合物骨架的制备，尤其是在吡唑、吖啶、苯腙类化合物，β‑氯‑α，β‑不饱和醛类化合物，β‑羰基或α，β‑不饱和的1,3‑二噻烷类化合物以及联烯类化合物制备中的应用。
摘要（英）：

The invention provides a beta-chloro-alpha, beta-nonsaturated-1,3-dithiane compound preparation method and use. The preparation method comprises that a solvent, 2-chloro-1,3-dithiane, an alkyne compound and iodine and/or di-tert-butyl peroxide are added into a reactor, the mixture undergoes a reaction at a certain temperature and the reaction product is separated and purified so that the corresponding beta-chloro-alpha, beta-nonsaturated-1,3-dithiane compound is obtained. The preparation method utilizes cheap and easily available raw materials and realizes high efficiency preparation of the beta-chloro-alpha, beta-nonsaturated-1,3-dithiane compound by simple mixing and stirring. The preparation method has the advantages of mild reaction conditions, high yield, environmental friendliness and atom economy. The beta-chloro-alpha, beta-nonsaturated-1,3-dithiane compound can be used for preparation of a plurality of useful compound skeletons and especially for preparation of pyrazole, acridine and phenyl hydrazone compounds, a beta-chloro-alpha, beta-nonsaturated aldehyde compound, a beta-carbonyl or alpha, beta-nonsaturated-1,3-dithiane compound and an allene compound.

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