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发明公开
CN105061208A 双醋瑞因新晶型化合物、制备方法及含有该化合物的药物组合物 无效 - 驳回

双醋瑞因新晶型化合物、制备方法及含有该化合物的药物组合物
摘要：
本发明公开了一种双醋瑞因化合物、制备方法及含有该化合物的药物组合物。所述双醋瑞因化合物其结晶的X-射线粉末衍射图的2θ在约为5.22°、10.47°处有其明显的特征吸收峰；在15.83°、17.46°、21.04°、21.89°、25.02°、27.90°和31.82°中的一处或多处有特征吸收峰；5.22°、10.47°两处的特征吸收峰峰面积之和占整个衍射图谱的80％以上。依次经过溶解、冷却、烘干等步骤制成。本发明所获得的双醋瑞因新晶型化合物具有更高的纯度和释放度，可提高生物利用度，减少双醋瑞因产生的腹泻等副作用。
摘要（英）：

The invention discloses a diacerein compound, a preparation method and a pharmaceutical composition including the compound. According to 2 theta of an X-ray powder diffraction pattern of the crystal of the diacerein compound, obvious characteristic absorption peaks occur at positions of 5.22 degrees and 10.47 degrees, and characteristic absorption peaks occur at one or more positions of 15.83 degrees, 17.46 degrees, 21.04 degrees, 21.89 degrees, 25.02 degrees, 27.90 degrees and 31.82 degrees; the sum of characteristic absorption peak areas of the two positions of 5.22 degrees and 10.47 degrees accounts for over 80% of the area of the whole diffraction pattern. The diacerein compound is prepared by adopting the steps of dissolving, cooling, drying and the like in sequence. According to the novel crystal diacerein compound, the preparation method and the pharmaceutical composition including the compound, the obtained novel crystal diacerein compound is higher in purity and releasing rate, the bioavailability can be improved, and side effects such as diarrhea caused by diacerein are reduced.

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