The invention relates to a highway roadside landscape color evaluation method based on driving fatigue, and belongs to the field of image analysis and evaluation. The highway roadside landscape color evaluation method comprises the following specific steps: obtaining and preprocessing data; extracting a landscape; carrying out landscape color quantization on the basis of K-means clustering; carrying out support vector machine-based driving fatigue discrimination by considering multiple physiological indexes; modeling influence relation to the physiological properties of a driver by quantized landscape colors; and carrying out landscape evaluation on the basis of the driving fatigue. Compared with the prior art, the invention has the characteristics that the landscape can be objectively and quantitatively evaluated, driver fatigue is considered, and a landscape design scheme can be evaluated in advance.