The invention relates to a medicine sort-out method and device, and in particular relates to a method and a device for dynamically sorting out boxed medicines. The method and device are characterized in that mechanical force is utilized for driving to sort out the medicines. The shortcomings of the overlapping type and gravity type methods and devices that large dynamic fluctuation occurs in sorting out and effective control cannot be realized are overcome. The method and device play important roles on increasing efficiency and decreasing error rate. According to the technical scheme, sort-out units and an integrated linkage transmission system are provided, wherein the sort-out units are arranged on a frame, and each sort-out unit comprises a medicine storing channel, a conveying mechanism and a sorting out device; each sort-out unit is used for sorting out the medicines and conveying the sorted-out medicines to the outside through the transmission mechanism. The method and device have the advantages that the structure is reasonable, the operation is simple, the practicability is high, the sort-out process is stable and reliable, the operation noise is low, and the applicable scope is wide; medicines can move smoothly in the medicine storing channel and can be emptied and checked by the reverse rotation of a motor. The method and device are high in sort-out efficiency, can greatly reduce the labor intensity of medical staff and greatly save the labor force, and have remarkable economic benefit as well as wide popularization and application prospect.