The invention provides a calibration device of a six-dimensional heavy force sensor, and belongs to the field of sensors as well as the measurement and the control thereof. By adopting a single force source, the calibration device is capable of calibrating the six-dimensional force of a force sensor. The calibration device comprises a base, a calibration workbench, an upright post, a lifting nut,a handle, a large force value loading mechanism adopting a worm wheel and a worm for transmission, an upper support tablet, a lead screw, a nut, a sleeve, a standard uni-directional force sensor, a ranging rod, a bolt, a connection block, an L-shaped plate, a sensor to be calibrated, a working shaft, a positioning pin, a base plate, a T-shaped bolt and a signal wire; and a mechanism to be calibrated consists of the ranging rod, the bolt, the connection block, the L-shaped plate, the sensor to be calibrated, the working shaft, the positioning pin and the base plate. The device is capable of loading the six-dimensional heavy force sensor and carrying out systematic calibration. The device has the characteristics of compact structure, simplicity, high rigidity and high precision, and can achieve precise calibration of the six-dimensional heavy force sensor.