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CN101386596A 3-亚烷基肼基取代的杂芳基化合物作为血小板生成素受体激活剂 失效 - 权利终止

3-亚烷基肼基取代的杂芳基化合物作为血小板生成素受体激活剂
摘要：
3－亚烷基肼基取代的杂芳基化合物作为血小板生成素受体激活剂。一种用式(1)表示的化合物，所述化合物的互变体、前药或药学上可接受的盐，或其溶剂化物，式中，A是氮原子或CR4，B是氧原子、硫原子或NR9(条件是，当A是氮原子时，B不是NH)，R1是C2－14芳基，L1是键，CR10R11、氧原子、硫原子或NR12，X是OR13、SR13或NR14NR15，R2是氢原子、甲酰基、C1－10烷基等，L2是键等，L3是键，CR17R18、氧原子、硫原子或NR19，L4是键，CR20R21、氧原子、硫原子或NR22，Y是氧原子、硫原子或NR23，R3是C2－14芳基。
摘要（英）：

3-alkylidenehydrazino substituted heteroaryl compounds as thrombopoietin receptor activators are provided. A compound is represented by the formula (1), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, wherein A is a nitrogen atom or CR<4>, B is an oxygen atom, a sulfur atom or NR<9> (provided that when A is a nitrogen atom, B is not NH), R<1> is a C<2-14>; aryl group, L<1> is a bond, CR<10>R<11>, an oxygen atom, a sulfur atom or NR<12>, X is OR<13>, SR<13> or NR<14>NR<15>, R<2> is a hydrogen atom, a formyl group, a C<1-10>; alkyl group or the like, L<2> is a bond or the like, L<3> is a bond, CR<17>R<18>, an oxygen atom, a sulfur atom or NR<19>, L<4> is a bond, CR<20>R<21>, an oxygen atom, a sulfur atom or NR<22>, Y is an oxygen atom, a sulfur atom or NR<23>, and R<3> is a C<2-14>.

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