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CN101368184A 铜绿假单胞菌泳动能力相关基因PA5001及应用 无效 - 撤回

铜绿假单胞菌泳动能力相关基因PA5001及应用
摘要：
本发明公开了铜绿假单胞菌泳动能力相关基因PA5001。属于微生物生物技术领域。此基因大小为957bp，目前国际上对该基因的功能尚没有报道，本实验首次发现其参与菌体的泳动能力。铜绿假单胞菌的泳动(swimming motility)是鞭毛介导的一种运动方式。本实验发现该基因的失活导致铜绿假单胞菌泳动能力丧失。铜绿假单胞菌的鞭毛及其所介导的运动能力是该菌的重要的毒力因子及致病因素。对该基因的发现及研究有助于研究铜绿假单胞菌鞭毛的运动机制，揭示铜绿假单胞菌的致病机理，为预防和治疗该菌引起的感染提供理论依据。
摘要（英）：

The invention discloses pseudomonas aeruginosa swimming motility related gene PA5001 which belongs to the technical field of microbial biology. The size of the gene is 957bp and has no international reports on the function of the gene at present. The experiment discovers that the gene participates in the swimming motility of thalli for the first time. The swimming motility (swimming motility) of pseudomonas aeruginosa is one motion mode of flagellum mediate. The experiment discovers that the inactivation of the gene results in the loss of the swimming motility of the pseudomonas aeruginosa. The flagella of the pseudomonas aeruginosa and the flagellum-mediated motion ability thereof are important virulence factors and pathogenic factors of the pseudomonas aeruginosa. The discovery and the study of the gene contribute to the study on the motion mechanism of the flagella of the pseudomonas aeruginosa, reveal the pathogenesis of the pseudomonas aeruginosa, and provide the theoretical basis for the prevention and the treatment of the infection which is caused by the pseudomonas aeruginosa.

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