The invention relates to a steel plate with high intensity and used in construction structures of high buildings with large thickness and a production method thereof. The steel plate of the invention consists of the following components according to weight percentage: less than or equal to 0.20 percent of C, less than or equal to 0.55 percent of Si, 1.00 to 1.70 percent of Mn, less than or equal to 0.025 percent of P, less than or equal to 0.010 percent of S, less than or equal to 0.70 percent of Ni, less than or equal to 0.70 percent of Cr, less than or equal to 0.20 percent of V, more than or equal to 0.015 percent of Nb, less than or equal to 0.20 percent of Ti, 0.020 to 0.060 percent of Al, and the rest is Fe and inevitable impurity. The produced Q460E-Z35 steel plate with a thicknessof 100 to 110 mm is capable of meeting the requirement of high intensity steel of large-thickness construction structure (Ceq is less than or equal to 0.50 percent); the steel plate of the invention can be applied to constructing the structure of high building, has good performance of welding and anti-layer tearing, can meet the requirement of on-site key stress points, has simple production process and is capable of realizing bulk production. The high intensity steel plate of the invention has the following advantages that (1) the steel quality of the invention is purer with less than or equal to 0.025 percent of P and less than or equal to 0.010 percent of S; (2) yield ratio of the invention is relatively low and less than 0.78 actually; (3) the anti-layer tearing performance is good, and Z is larger than or equal to 35 percent in whole thickness direction; (4) low-temperature toughness at the temperature of minus 40 DEG C is good; (5) maximum thickness of the steel plate can reach 110mm.