公开(公告)号：US20240183850A1

公开(公告)日：2024-06-06

申请号：US18530252

申请日：2023-12-06

Applicant: SEIKO EPSON CORPORATION

Inventor： Chikara KOJIMA ,  Masamitsu MOCHIZUKI ,  Shinji TERAO ,  Keita KUBO ,  Kazuki Sano ,  Kiyoaki MURAI ,  Masahiko KOBAYASHI

IPC: G01N33/551

CPC classification number: G01N33/551

Abstract: Provided is a replica of a biological material, which has a three-dimensional structure similar to a three-dimensional structure of the biological material and has a surface made of an inorganic material. The inorganic material may be an oxide or a nitride. The replica may include a body and a coating film which covers a surface of the body and is made of the inorganic material.

公开(公告)号：US20220260559A1

公开(公告)日：2022-08-18

申请号：US17518016

申请日：2021-11-03

Applicant: Seer, Inc.

Inventor： John BLUME ,  Ryan BENZ ,  Asim SIDDIQUI ,  Philip MA

IPC: G01N33/543 ,  G01N33/551 ,  G01N33/68

Abstract: Disclosed herein are compositions, systems, and methods for identifying neurological diseases from biological sample analysis. A biological sample from a subject may be contacted to a particle to form a biomolecule corona, which may contain a subset of biomolecules from the biological sample and which can have utility for diagnosing a neurological disease state. Further disclosed herein are machine learning algorithms and trained classifiers for distinguishing neurological disease states based on biological data.

公开(公告)号：US11199540B2

公开(公告)日：2021-12-14

申请号：US16892097

申请日：2020-06-03

Applicant: Illumina Cambridge Limited

Inventor： Xavier von Hatten ,  Wayne N. George ,  Alexandre Richez ,  Anne-Cecile Dingwall ,  Andrew A. Brown

IPC: G01N33/543 ,  C12Q1/6834 ,  C12Q1/6869 ,  G01N33/551 ,  C12N11/10 ,  C09D183/04

Abstract: Some examples described herein relate to a substrate comprising a silane functionalized surface for reversibly immobilizing a biological molecule of interest, such as oligonucleotides, polynucleotides, or protein. Methods for immobilizing the biological molecule and the use in DNA sequencing and other diagnostic applications are also disclosed.

公开(公告)号：US11112379B2

公开(公告)日：2021-09-07

申请号：US16027403

申请日：2018-07-05

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Gil Shalev ,  Yossi Rosenwaks

IPC: G01N33/551 ,  G01N27/414 ,  G01N33/543 ,  G01N27/12 ,  G01N27/30 ,  H01L21/22 ,  H01L21/324

Abstract: The present invention provides a method and a system based on a multi-gate field effect transistor for sensing molecules in a gas or liquid sample. The said FET transistor comprises dual gate lateral electrodes (and optionally a back gate electrode) located on the two sides of an active region, and a sensing surface on top of the said active region. Appling voltages to the lateral gate electrodes, creates a conductive channel in the active region, wherein the width and the lateral position of the said channel can be controlled. Enhanced sensing sensitivity is achieved by measuring the channels conductivity at a plurality of positions in the lateral direction. The use of an array of the said FTE for electronic nose is also disclosed.

公开(公告)号：US11029310B2

公开(公告)日：2021-06-08

申请号：US13804122

申请日：2013-03-14

Applicant: Wisconsin Alumni Research Foundation

Inventor： David J. Beebe ,  Scott M. Berry

IPC: G01N33/551 ,  G01N33/543 ,  G01N1/34 ,  G01N1/40 ,  B01L3/00

Abstract: A device and a method for isolating a target from a sample are provided. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes a first plate having a first region for receiving at least a portion of the sample. A second plate is spaced from the first plate by a distance and has a first region for receiving a reagent. A force attracts the target bound solid phase substrate toward the first region of the second plate such that the target bound solid phase substrate in the portion of the sample are drawn through the air gap and into the reagent by the force.

公开(公告)号：US20200300844A1

公开(公告)日：2020-09-24

申请号：US16763452

申请日：2018-11-13

Applicant: Stellenbosch University

Inventor： Etheresia Pretorius ,  Anna Martha Engelbrecht ,  Willem Jacobus Perold ,  Deon Pieter Neveling

IPC: G01N33/543 ,  G01N33/551

Abstract: A method, system, test strip, point-of-care device and computer-implemented method for detecting a level of inflammation in a subject is provided. The level of inflammation is detected by contacting a biological sample obtained from the subject with a serum amyloid A (SAA) capture agent. The capture agent is secured to a substrate and is configured to emit a signal upon binding to SAA. The signal is detected and a result indicating the level of inflammation in the subject is output.

公开(公告)号：US10705047B2

公开(公告)日：2020-07-07

申请号：US16364530

申请日：2019-03-26

Applicant: University of Utah Research Foundation

Inventor： Swomitra Kumar Mohanty ,  Manoranjan Misra ,  Younghwan Kim ,  Jules Magda

IPC: G01N27/49 ,  G01N33/551 ,  G01N33/497

Abstract: Functionalized nanotube arrays, sensors, and related methods of detecting target compounds are presented. A functionalized nanotube array can include a plurality of metal oxide nanotubes. The metal oxide nanotubes can be formed of a metal oxide and can have an interior or exterior surface that is optionally functionalized with at least one metal ion. These metal nanotubes can be used in a sensor for detecting target compounds such as volatile organic compounds, and biomarkers in a fluid environment. The sensor can further include a power source configured to apply a voltage to the nanotube array and a current sensor configured to monitor and detect changes in a response current which varies upon binding with the target compounds.

公开(公告)号：US10684281B2

公开(公告)日：2020-06-16

申请号：US15970702

申请日：2018-05-03

Applicant: Illumina Cambridge Limited

Inventor： Xavier von Hatten ,  Wayne N. George ,  Alexandre Richez ,  Anne-Cecile Dingwall ,  Andrew A. Brown

IPC: G01N33/543 ,  C12Q1/6834 ,  C12Q1/6869 ,  G01N33/551 ,  C12N11/10 ,  C09D183/04

Abstract: Some embodiments described herein relate to a substrate comprising a silane functionalized surface for reversibly immobilizing a biological molecule of interest, such as oligonucleotides, polynucleotides, or protein. Methods for immobilizing the biological molecule and the use in DNA sequencing and other diagnostic applications are also disclosed.

公开(公告)号：US10529003B2

公开(公告)日：2020-01-07

申请号：US15731577

申请日：2017-07-03

Applicant: Mohammad A. Mazed

Inventor： Mohammad A. Mazed

IPC: G01N33/551 ,  G06Q30/06 ,  G06Q30/02 ,  H04W4/029 ,  G01N33/543 ,  G06Q20/12

Abstract: An optical biomodule for detecting a disease specific biomarker(s), utilizing enhanced fluorescence emission (due to integration of a three-dimensional (3-D) protruded structure (s)) in a fluidic container/zero-mode waveguide, upon chemical binding of a disease specific biomarker(s) with its corresponding disease specific biomarker binder(s) (e.g., an aptamer(s)) is disclosed.

公开(公告)号：US10527625B2

公开(公告)日：2020-01-07

申请号：US15202710

申请日：2016-07-06

Applicant: Wei-Heng Shih ,  Wan Y. Shih ,  Giang Au ,  Ari D. Brooks ,  Vanlila K. Swami

Inventor： Wei-Heng Shih ,  Wan Y. Shih ,  Giang Au ,  Ari D. Brooks ,  Vanlila K. Swami

IPC: G01N33/551 ,  G01N33/574 ,  G01N33/532 ,  G01N33/58 ,  B82Y15/00 ,  C07K16/22 ,  C07K16/30 ,  G01N33/533 ,  B82Y5/00 ,  B82Y40/00

Abstract: One or more aqueous, near infrared emitting, high yield, highly photoluminescent, stable quantum dots conjugated to one or more biomarkers specific moieties. The conjugated quantum dots have an enhanced detection sensitivity and selectivity and may be formed using a novel and efficient method for conjugating one or more biomarker specific moieties to the quantum dots. The invention is further directed to a method for using the conjugated quantum dots for cancer detection in the margin of excised tissue.