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公开(公告)号：US12128106B2
公开(公告)日：2024-10-29
申请号：US18584914
申请日：2024-02-22
发明人： Mark George Saulnier , Jesse Jingyang Chen , Srinivasa Karra , Kevin Tyler Sprott , Jason Allan Wiles , Soumya Ray
IPC分类号： A61K47/54 , A61K47/62 , C07H5/06 , C07H7/02 , C07H9/02 , C07H9/04 , C07H15/203 , C07H17/00 , C07H17/02 , C07H19/02 , C07H19/044 , H03L7/081 , H03L7/099
CPC分类号： A61K47/549 , A61K47/62 , C07H5/06 , C07H7/02 , C07H9/02 , C07H9/04 , C07H15/203 , C07H17/00 , C07H17/02 , C07H19/02 , C07H19/044 , H03L7/0814 , H03L7/0818 , H03L7/0998
摘要： Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.
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公开(公告)号：US20240182506A1
公开(公告)日：2024-06-06
申请号：US18403174
申请日：2024-01-03
发明人： Paul Keitz , Gus Bergnes , Mark A. Gallop , Marco Quarta
摘要： Provided herein are novel sugar derivatives which are intermediates for preparing senolytic agents that selectively kill senescent cells associated with numerous pathologies and discases. including age-related pathologies and discases.
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公开(公告)号：US11897915B2
公开(公告)日：2024-02-13
申请号：US17944019
申请日：2022-09-13
发明人： Paul Keitz , Gus Bergnes , Mark A. Gallop , Marco Quarta
摘要： Provided herein are novel sugar derivatives which are intermediates for preparing senolytic agents that selectively kill senescent cells associated with numerous pathologies and diseases, including age-related pathologies and diseases.
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公开(公告)号：US11339184B2
公开(公告)日：2022-05-24
申请号：US16936900
申请日：2020-07-23
发明人： Sean F. Brady , James Peek
摘要： The present disclosure includes novel compounds useful as antimicrobial agents. The present disclosure further includes methods useful. The present disclosure further includes compositions and methods for treating or preventing a bacterial infection. The present disclosure further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms.
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公开(公告)号：US11186602B2
公开(公告)日：2021-11-30
申请号：US16965438
申请日：2019-01-29
发明人： Zheng Gu , Wuyong Wu , Panpan Kang , Tong Qu , Zongyuan Zhang , Weiming Huang , Tianyun Wu , Yingjun Zhang
IPC分类号： C07H9/04 , A61P3/10 , A61K31/7048 , A61K45/06
摘要： A glucopyranosyl derivative is used as an inhibitor of sodium-dependent glucose transporters (SGLTs), particularly being used as an inhibitor of sodium-dependent glucose transporter-1 (SGLT1), and a pharmaceutically acceptable salt or stereoisomer thereof, further relating to a pharmaceutical composition containing the derivative. The compound and a pharmaceutical composition is used thereof in the preparation of a drug for treating diabetes and diabetes-related diseases.
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公开(公告)号：US20210054013A1
公开(公告)日：2021-02-25
申请号：US16965438
申请日：2019-01-29
发明人： Zheng GU , Wuyong WU , Panpan KANG , Tong QU , Zongyuan ZHANG , Weiming HUANG , Tianyun WU , Yingjun ZHANG
IPC分类号： C07H9/04 , A61K45/06 , A61K31/7048 , A61P3/10
摘要： A glucopyranosyl derivative is used as an inhibitor of sodium-dependent glucose transporters (SGLTs), particularly being used as an inhibitor of sodium-dependent glucose transporter-1 (SGLT1), and a pharmaceutically acceptable salt or stereoisomer thereof, further relating to a pharmaceutical composition containing the derivative. The compound and a pharmaceutical composition is used thereof in the preparation of a drug for treating diabetes and diabetes-related diseases.
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公开(公告)号：US10544181B2
公开(公告)日：2020-01-28
申请号：US15755393
申请日：2016-08-25
申请人： KYUSHU UNIVERSITY , Institute of Systems, Information Technologies and Nanotechnologies , NISSIAN CHEMICAL INDUSTRIES, LTD.
IPC分类号： C07H9/04 , A61K8/60 , C09K3/00 , A61K47/26 , A61Q1/02 , A61K8/04 , C07B37/04 , C07C43/32 , C07C233/03
摘要： A novel gelator including a sugar derivative; a gelator including a compound of Formula (1) or Formula (2): wherein R1 is a linear or branched alkyl group having a carbon atom number of 9 to 20, a cyclic alkyl group having a carbon atom number of 13 to 20, or a linear or branched alkenyl group having a carbon atom number of 9 to 20, R2 is a hydrogen atom, a linear or branched alkyl group having a carbon atom number of 1 to 10, or an aryl group optionally having a substituent, and R3 and R4 are hydroxy groups.
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8.发明授权公开(公告)号：US10011627B2
公开(公告)日：2018-07-03
申请号：US14917792
申请日：2014-08-19
发明人： Huijuan Zhong , Jianchun Liao , Hongping Yu , Yaochang Xu , Qing Li , Jianghua Chen , Peng Gao , Songliang Tan , Shaobao Wang
IPC分类号： C07H7/06 , C07H9/04 , C07D409/10 , C07D409/14 , A61K31/00 , C07H7/04 , A61K31/7048 , C07D493/08
CPC分类号： C07H7/06 , A61K31/00 , A61K31/7048 , C07D409/10 , C07D409/14 , C07D493/08 , C07H7/04 , C07H9/04
摘要： C-aryl glucoside derivatives, preparation methods thereof, and medical applications thereof are described. Specifically, compounds represented by formula I, and, tautomers, enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts of the compounds, preparation methods thereof, pharmaceutical compositions containing the compounds, and applications thereof are described. Compounds of formula (I) are useful as therapeutic agents, and particularly as sodium-dependent glucose contransporter protein (SGLT) inhibitors.
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公开(公告)号：US09777015B2
公开(公告)日：2017-10-03
申请号：US14415988
申请日：2013-07-16
申请人： METABRAIN RESEARCH
发明人： Franck F. Lepifre , Gersande R. Lena , Valerie Autier , Micheline R. Kergoat , Lauren R. Faveriel , Christine G. Charon , Sophie N. Raynal , Annick M. Audet
IPC分类号： A61K31/4025 , C07D493/14 , C07D333/24 , C07D333/34 , C07D333/38 , C07D333/40 , C07H9/04 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , A61K31/381 , A61K31/4436 , A61K31/5377 , A61K45/06
CPC分类号： C07D493/14 , A61K31/381 , A61K31/4025 , A61K31/4436 , A61K31/5377 , A61K45/06 , C07D333/24 , C07D333/34 , C07D333/38 , C07D333/40 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07H9/04
摘要： The present invention relates to a thiophene derivative of the following general formula I or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt thereof or to its use as a drug in particular intended for treating and/or preventing diabetes, its complications and/or associated pathologies, advantageously diabetes of type II and hyperglycemia.
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公开(公告)号：US09403862B2
公开(公告)日：2016-08-02
申请号：US14445917
申请日：2014-07-29
发明人： Clay S. Bennett , John P. Issa , Dina Lloyd
IPC分类号： C07H1/00 , C07H5/10 , C07H15/18 , C07H15/207 , C07H9/04
CPC分类号： C07H19/01 , C07B2200/07 , C07H1/00 , C07H3/04 , C07H5/10 , C07H9/04 , C07H13/00 , C07H15/14 , C07H15/18 , C07H15/203
摘要： Provided are methods for the efficient stereoselective formation of glycosidic bonds, without recourse to prosthetic or directing groups.
摘要翻译： 提供了用于有效立体选择性形成糖苷键的方法，而无需求助于假体或引导组。
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