公开(公告)号：US12110308B2

公开(公告)日：2024-10-08

申请号：US16960819

申请日：2019-01-08

申请人： NUCORION PHARMACEUTICALS, INC.

发明人： Lin Zhi

IPC分类号： C07F9/6561 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/44 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/7052 ,  A61K31/7056 ,  A61K31/7076 ,  A61K38/21 ,  A61K45/06 ,  A61P1/16

CPC分类号： C07F9/65616 ,  A61K31/4178 ,  A61K31/44 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/7056 ,  A61K38/212 ,  A61K45/06 ,  A61P1/16 ,  A61K31/4162 ,  A61K31/7052 ,  A61K31/7076

摘要： Provided herein are phosphor (n) amidatacetal and phosph (on) atacetal compounds, their preparation and their uses, such as treating liver diseases or nonliver diseases via intervening in the molecular pathways in the liver. These compounds may be effective in the treatment of hepatitis or other viral infections either alone or in combination with one or more additional therapeutic agents.

公开(公告)号：US12082500B2

公开(公告)日：2024-09-03

申请号：US15371066

申请日：2016-12-06

申请人： Samsung Display Co., Ltd

发明人： Junha Park ,  Youngkook Kim ,  Munki Sim ,  Eunyoung Lee ,  Hyoyoung Lee ,  Eunjae Jeong ,  Seokhwan Hwang

IPC分类号： H10K85/60 ,  C07D221/18 ,  C07D401/10 ,  C07D405/10 ,  C07D471/04 ,  C07F9/576 ,  C07F9/6558 ,  C07F9/6561 ,  H10K50/16 ,  H10K50/17 ,  H10K50/18

CPC分类号： H10K85/6572 ,  C07D221/18 ,  C07D401/10 ,  C07D405/10 ,  C07D471/04 ,  C07F9/5765 ,  C07F9/65583 ,  C07F9/6561 ,  H10K85/626 ,  H10K85/654 ,  H10K85/6574 ,  H10K50/16 ,  H10K50/171 ,  H10K50/18

摘要： Provided are a condensed cyclic compound and an organic light-emitting device. The condensed cyclic compound is represented by Formula 1:




Details about the constituents of Formula 1 is disclosed.

公开(公告)号：US20240279258A1

公开(公告)日：2024-08-22

申请号：US18594725

申请日：2024-03-04

申请人： Forward Therapeutics, Inc.

发明人： Toufike KANOUNI

IPC分类号： C07F9/6561 ,  A61K9/08 ,  A61K9/48 ,  C07D471/02 ,  C07F9/6558 ,  C07F9/6584

CPC分类号： C07F9/6561 ,  A61K9/08 ,  A61K9/4825 ,  C07D471/02 ,  C07F9/65583 ,  C07F9/6584

摘要： Provided herein are inhibitors of TNF-α, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the TNF-α inhibitory compounds for the treatment of diseases or disorders.

公开(公告)号：US20240248094A1

公开(公告)日：2024-07-25

申请号：US18425634

申请日：2024-01-29

申请人： SONY GROUP CORPORATION

发明人： Tracy MATRAY ,  Sharat SINGH

IPC分类号： G01N33/58 ,  C07F9/09 ,  C07F9/572 ,  C07F9/576 ,  C07F9/6558 ,  C07F9/6561 ,  C09B3/14 ,  C09B11/26 ,  C09B69/10 ,  G01N33/52 ,  G01N33/533

CPC分类号： G01N33/582 ,  C07F9/091 ,  C07F9/572 ,  C07F9/65583 ,  C07F9/65586 ,  C07F9/6561 ,  C09B3/14 ,  C09B11/26 ,  C09B69/101 ,  C09B69/102 ,  C09B69/103 ,  C09B69/109 ,  G01N33/52 ,  G01N33/533 ,  C07F9/09 ,  C07F9/094 ,  C07F9/098 ,  C07F9/5765

摘要： Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I):




or a stercoisomer, tantomer or salt thereof, wherein R1, R2, R3, R4, R5, L1, L2, L3, L4, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.

公开(公告)号：US20240228521A1

公开(公告)日：2024-07-11

申请号：US18554795

申请日：2022-04-14

申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.

发明人： David SPERANDIO ,  Helena SHOMAR MONNGES ,  Eugene J. EISENBERG ,  Arthur MACHLENKIN

IPC分类号： C07F9/6561 ,  A61K31/675

CPC分类号： C07F9/6561 ,  A61K31/675

摘要： Disclosed herein are 3, 4-didehydro- and 3′-deoxy-3, 4-didehydro-compounds, and pharmaceutical compositions thereof. The 3, 4-didehydro- and 3′-deoxy-3, 4-didehydro-compounds, and pharmaceutical compositions thereof may be used in methods of treating diseases including virus-induced diseases, cancer, autoimmune diseases, immune disorders, and bacterial-associated diseases or infections, or combinations thereof. Examples of viral-induced diseases include viral infections by RNA or DNA viruses, for example SARS-CoV-2, EBV, and BKV.

公开(公告)号：US20240228503A1

公开(公告)日：2024-07-11

申请号：US18586620

申请日：2024-02-26

申请人： GlaxoSmithKline Intellectual Property Development Limited

发明人： Adam K. CHARNLEY ,  Janos BOTYANSZKI ,  Xiaoyang DONG ,  Philip Gareth HUMPHREYS ,  Bryan Wayne KING ,  Kimberly Katherine MARCUS ,  Joseph PERO ,  Alexander Joseph REIF ,  Daohua ZHANG ,  Attiq RAHMAN(Deceased) ,  Kenneth Allen NEWLANDER ,  Kenneth WIGGALL ,  Joshi RAMANJULU

IPC分类号： C07D487/04 ,  C07D403/14 ,  C07D471/04 ,  C07D471/14 ,  C07F9/6561

CPC分类号： C07D487/04 ,  C07D403/14 ,  C07D471/04 ,  C07D471/14 ,  C07F9/6561

摘要： The present invention relates to compounds, compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.

公开(公告)号：US12030904B2

公开(公告)日：2024-07-09

申请号：US18301179

申请日：2023-04-14

申请人： Gilead Sciences, Inc.

发明人： Scott E. Lazerwith ,  Jonathan William Medley ,  Philip A. Morganelli ,  Devan Naduthambi ,  Thomas P. Stratton ,  Peiyuan Wang

IPC分类号： C07F9/6561 ,  A61P31/12

CPC分类号： C07F9/6561 ,  A61P31/12

摘要： Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US12030903B2

公开(公告)日：2024-07-09

申请号：US17178115

申请日：2021-02-17

申请人： Gilead Sciences, Inc.

发明人： Daniel H. Byun ,  Gregory F. Chin ,  Michael O. Clarke ,  Bindu Goyal ,  Petr Jansa ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel

IPC分类号： C07F9/6561 ,  A61K45/06

CPC分类号： C07F9/6561 ,  A61K45/06

摘要： The present disclosure describes 4′-fluoromethyl nucleosides for treating viral infections, including Dengue.

公开(公告)号：US20240217964A1

公开(公告)日：2024-07-04

申请号：US18283339

申请日：2022-03-22

申请人： Newave Pharmaceutical Inc.

发明人： Yi Chen

IPC分类号： C07D453/02 ,  A61K31/439 ,  A61K31/4748 ,  A61K31/675 ,  A61P35/00 ,  C07D471/08 ,  C07F9/6561

CPC分类号： C07D453/02 ,  A61K31/439 ,  A61K31/4748 ,  A61K31/675 ,  A61P35/00 ,  C07D471/08 ,  C07F9/6561

摘要： The disclosure includes compounds of either Formula (A), wherein R1, R2, R3, R4, m, n, k, r, s, t, and L are defined herein; or Formula (I), wherein R1, R2, R3, m, n, and k are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.

公开(公告)号：US12012427B2

公开(公告)日：2024-06-18

申请号：US17085201

申请日：2020-10-30

申请人： INDIAN ASSOCIATION FOR THE CULTIVATION OF SCIENCE

发明人： Surajit Sinha ,  Jayanta Kundu ,  Ujjwal Ghosh

IPC分类号： C08G73/06 ,  C07F9/6533 ,  C07F9/6558 ,  C07F9/6561

CPC分类号： C07F9/65616 ,  C07F9/6533 ,  C07F9/65583 ,  C08G73/06

摘要： Present invention relates to stable Fmoc protected Morpholino monomers and corresponding oligonucleotides (PMO) and efficient synthesis of the same involving chlorophosphoramidate and H-Phosphonate chemistry. Successful syntheses of the oligonucleotide with higher yield and lesser time have been accomplished employing solid phase synthesis and easy deprotection of Fmoc group with Piperidine.