公开(公告)号：US20230136988A1

公开(公告)日：2023-05-04

申请号：US18046270

申请日：2022-10-13

申请人： Daiichi Sankyo Company, Limited

发明人： Keiji Saito ,  Katsuyoshi Nakajima ,  Toru Taniguchi ,  Osamu Iwamoto ,  Satoshi Shibuya ,  Yasuyuki Ogawa ,  Kazumasa Aoki ,  Nobuya Kurikawa ,  Shinji Tanaka ,  Momoko Ogitani ,  Eriko Kioi ,  Kaori Ito ,  Natsumi Nishihama ,  Tsuyoshi Mikkaichi ,  Wataru Saitoh

IPC分类号： C07D307/94 ,  C07D405/04 ,  C07D413/04 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/343 ,  C07D405/10 ,  C07D407/12 ,  C07D413/10 ,  C07D413/14

摘要： An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof.
The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: R1: e.g., a C1-C6 alkyl group; R2: a C1-C6 alkyl group; A: e.g., an oxygen atom; and R3: e.g., a C1-C6 alkyl group.

公开(公告)号：US20230126480A1

公开(公告)日：2023-04-27

申请号：US17905531

申请日：2021-03-02

申请人： HELIOEAST PHARMACEUTICAL CO., LTD. ,  HELIOEAST SCIENCE & TECHNOLOGY CO., LTD.

发明人： Lingyun WU ,  Peng YANG ,  Lele ZHAO ,  Xu YOU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D413/04

摘要： Disclosed are a series of benzo 2-azaspiro[4.4]nonane compounds, and specifically disclosed are a compound as represented by formula (P) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230117403A1

公开(公告)日：2023-04-20

申请号：US17796542

申请日：2021-01-29

申请人： FMC Corporation

发明人： Omar Khaled AHMAD ,  Twyla A. BRIDDELL ,  Dominic Ming-Tak CHAN ,  Yuzhong CHEN ,  Jason Charles HAMM ,  Moumita KAR ,  Thomas Francis PAHUTSKI, JR. ,  Thomas Martin STEVENSON ,  Ming XU ,  Rachel SLACK

IPC分类号： A01N43/647 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D409/04 ,  C07D405/14 ,  C07D401/14 ,  A01N43/56 ,  A01N43/653 ,  A01N43/40 ,  A01N43/713 ,  A01N43/50 ,  A01N43/82 ,  A01N43/76 ,  A01N43/78 ,  A01N43/80 ,  A01P7/04 ,  A01N25/14 ,  A01N25/04 ,  A01N25/12 ,  A01N25/08 ,  A01N25/34 ,  A01N51/00

摘要： Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, Wherein R1, A, R2, R4, R5 and Q are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the disclosure.

公开(公告)号：US11629134B2

公开(公告)日：2023-04-18

申请号：US17128021

申请日：2020-12-19

申请人： Merck Patent GmbH

发明人： Brian A. Sherer ,  Nadia Brugger

IPC分类号： C07D471/04 ,  C07D401/04 ,  C07D241/42 ,  C07D405/14 ,  C07D413/14 ,  C07D417/04 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/14 ,  C07D413/04 ,  C07D487/04

摘要： Compounds of Formula 1 and pharmaceutically acceptable compositions thereof are useful as TLR7/8 antagonists.

公开(公告)号：US20230114845A1

公开(公告)日：2023-04-13

申请号：US18062744

申请日：2022-12-07

申请人： SYNGENTA CROP PROTECTION AG

发明人： James Alan MORRIS ,  Sally Elizabeth RUSSELL ,  Sean NG

IPC分类号： C07D403/04 ,  A01N43/54 ,  A01N43/58 ,  A01N43/80 ,  A01N43/90 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  A01N43/56

摘要： The present invention relates to nitro-vinyl-pyrazole compounds of formula (B) wherein ring A, RB2 and RB3 are as defined in claim 1, as well as the manufacture of such compounds and their subsequent use in the production of agrochemicals and/or pharmaceuticals.

公开(公告)号：US20230112172A1

公开(公告)日：2023-04-13

申请号：US18062896

申请日：2022-12-07

申请人： Hoffmann-La Roche Inc.

发明人： Virginie BROM ,  Luke GREEN ,  Christian KRAMER ,  Dmitry MAZUNIN ,  Emmanuel PINARD ,  Hasane RATNI

IPC分类号： C07D413/04 ,  C07D403/04

摘要： The invention provides novel compounds having the general formula I wherein R1, R2, and R3 are as defined herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US11623921B2

公开(公告)日：2023-04-11

申请号：US17110643

申请日：2020-12-03

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Qingjie Liu ,  Scott Hunter Watterson ,  John E. Macor ,  Khehyong Ngu ,  Saleem Ahmad

IPC分类号： C07D417/04 ,  C07D401/10 ,  C07D403/12 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D209/18 ,  A61P29/00 ,  A61P37/00 ,  C07D209/08

摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

公开(公告)号：USRE49481E1

公开(公告)日：2023-04-04

申请号：US17075948

申请日：2020-10-21

申请人： Hoffmann-La Roche Inc.

发明人： Li Chen ,  Lichun Feng ,  Song Feng ,  Lu Gao ,  Tao Guo ,  Mengwei Huang ,  Chungen Liang ,  Yongfu Liu ,  Lisha Wang ,  Jason Christopher Wong ,  Jim Zhen Wu ,  Xihan Wu ,  Hongying Yun ,  Xiufang Zheng

IPC分类号： C07D493/10 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D487/04 ,  C07D491/107

摘要： A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.

公开(公告)号：US11618759B2

公开(公告)日：2023-04-04

申请号：US17582561

申请日：2022-01-24

申请人： LG Chem, Ltd.

发明人： Ki Won Han ,  A Rim Kim ,  Seung Hwan Jung

IPC分类号： C07D209/86 ,  C07D409/04 ,  C07D417/04 ,  C07D413/04 ,  C07D265/38 ,  C07F17/00 ,  C07F7/28 ,  C08F4/642 ,  C08F4/659 ,  C08F4/6592 ,  C08F210/16 ,  B01J31/18

摘要： The present invention provides a novel ligand compound, a transition metal compound and a catalyst composition including the same.

公开(公告)号：US11617750B2

公开(公告)日：2023-04-04

申请号：US16550763

申请日：2019-08-26

申请人： Acetylon Pharmaceuticals, Inc.

发明人： John H. van Duzer ,  Ralph Mazitschek ,  Walter Ogier ,  James E. Bradner ,  Guoxiang Huang ,  Dejian Xie ,  Nan Yu

IPC分类号： C07D235/30 ,  C07D239/42 ,  C07D241/20 ,  C07C259/06 ,  C07D213/74 ,  C07D277/82 ,  C07D209/48 ,  C07D401/12 ,  C07D417/06 ,  C07D213/81 ,  C07D401/06 ,  C07D403/04 ,  C07D213/30 ,  C07D277/24 ,  C07D209/46 ,  C07D413/04 ,  C07D401/04 ,  C07D263/58 ,  C07C237/36 ,  A61K31/505 ,  A61K31/164 ,  A61K31/337 ,  A61K45/06

摘要： The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.