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1.发明授权Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase 有权恶性疟原虫二氢乳清酸脱氢酶的小分子抑制剂公开(公告)号：US08703811B2
公开(公告)日：2014-04-22
申请号：US12991305
申请日：2009-05-07
Applicant: Cecilia Bastos , Michael L. Booker , Cassandra A. Celatka , Jon C. Clardy , Joseph Cortese , Vishal P. Patel , Renato Skerlj , Roger C. Wiegand , Dyann F. Wirth
Inventor： Cecilia Bastos , Michael L. Booker , Cassandra A. Celatka , Jon C. Clardy , Joseph Cortese , Vishal P. Patel , Renato Skerlj , Roger C. Wiegand , Dyann F. Wirth
IPC: A61K31/381 , A61K31/4184 , C07D333/30 , C07D235/06
CPC classification number: C07D333/38 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14
Abstract: Inhibitors of dihydroorotate dehydrogenase (DHODH) for the Plasmodium enzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly cytotoxic.
Abstract translation: 已经鉴定和表征了用于疟原虫酶的二氢乳清酸脱氢酶（DHODH）的抑制剂。 抑制剂具有高特异性，对培养的寄生虫菌株的亚微量功效，表现出药物样性质，并且不显着细胞毒性。
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2.发明授权Production of carboxylic acids,esters,acid chlorides,anhydrides,and ketones by reaction of an organometallic compound with carbon monoxide 失效通过与一氧化碳反应的有机化合物生产羧酸，酯，酸性氯化物，异氰酸酯和酮
公开(公告)号：US3745173A
公开(公告)日：1973-07-10
申请号：US3745173D
申请日：1970-07-31
Applicant: HERCULES INC
Inventor： HENRY P
IPC: C07C45/00 , C07C45/49 , C07C45/59 , C07C51/10 , C07C51/58 , C07C63/04 , C07D333/30 , C07F15/00 , C07D5/26 , C07D63/16
CPC classification number: C07F15/0013 , C07C45/00 , C07C45/49 , C07C45/59 , C07C51/10 , C07C51/58 , C07C201/12 , C07C49/84 , C07C63/24 , C07C65/21 , C07C63/06 , C07C63/26 , C07C63/04 , C07C65/24 , C07C63/36 , C07C63/10 , C07C205/45
Abstract: AN ORGANOMETHAL COMPOUND OF A PLATINUM GROUP METAL WHERE THE ORGANO GROUP IS ARYL, THIENYL, OR FURYL REACTS WITH CARBON MONOXIDE TO PRODUCE A DIORGANOKETONE AND A CARBOXYLIC COMPOUND WHICH IS AN ACID ANHYDRIDE, AN ACID OR AN ESTER AND THE ORGANOMETAL COMPOUND CAN BE MADE IN SITU FROM THE CORRESPONDING ORGANOMERCURY COMPOUND FOR THIS PURPOSE.
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公开(公告)号：US3657432A
公开(公告)日：1972-04-18
申请号：US3657432D
申请日：1970-04-20
Applicant: MERCK & CO INC
Inventor： SHEN TSUNG-YING , WALFORD GORDON L , WITZEL BRUCE E
IPC: A61K31/60 , A61K31/625 , C07C69/84 , C07C317/00 , C07D207/34 , C07D307/54 , C07D307/56 , C07D307/64 , C07D333/26 , C07D333/28 , C07D333/30 , C07D333/34 , C07D333/36 , C07D333/38 , C07D333/42
CPC classification number: C07C317/00 , C07C323/00 , C07D207/34 , C07D307/64 , C07D333/26 , C07D333/28 , C07D333/30 , C07D333/38 , C07D333/42
Abstract: SALICYLIC ACID DERIVATIVES AND THEIR NON-TOXIC PHARMACEUTICALLY ACCEPTABLE SALTS, ESTERS AND AMIDES ARE CLAIMED. ALSO ENCOMPASSED IS THE TREATMENT OF INFLAMMATION WITH SAID DERIVATIVES.
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公开(公告)号：US2492660A
公开(公告)日：1949-12-27
申请号：US70986846
申请日：1946-11-14
Applicant: SOCONY VACUUM OIL CO INC
Inventor： SCHICK JOHN W
IPC: C07D333/30
CPC classification number: C07D333/30
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5.发明授权Aromatic diselenides and selenosulfides, their preparation and their uses, more particularly their therapeutical use 失效芳族二硒化物和硒硫化物，其制备及其用途，更具体地说是其治疗用途
公开(公告)号：US6040328A
公开(公告)日：2000-03-21
申请号：US387593
申请日：1999-08-31
Applicant: Catherine Tailhan-Lomont , Irene Erdelmeier , Marc Moutet , Jean Chaudiere , Jean-Claude Yadan
Inventor： Catherine Tailhan-Lomont , Irene Erdelmeier , Marc Moutet , Jean Chaudiere , Jean-Claude Yadan
IPC: A61K31/095 , A61K31/38 , A61K31/381 , A61K31/415 , A61K31/425 , A61K31/426 , A61K31/495 , A61K31/555 , A61K38/00 , A61P1/00 , A61P9/00 , A61P11/00 , A61P27/02 , A61P31/12 , A61P37/04 , A61P43/00 , C07C391/02 , C07D233/66 , C07D277/20 , C07D277/32 , C07D333/26 , C07D333/30 , C07D517/04 , C07K5/08 , A61K31/335 , C07D277/04 , C07D333/32
CPC classification number: C07D517/04 , C07C391/02 , C07D233/66 , C07D333/30
Abstract: The objects of the present invention are:novel organoselenium compounds: aromatic diselenides and selenosulphides;the use of said novel compounds as antioxidant agents;pharmaceutical compositions containing them;a method of preparation of said novel compounds.Said novel cyclic organoselenium compounds have the general formula (I): ##STR1##
Abstract translation: 本发明的目的是：新型有机硒化合物：芳族二硒化物和硒代硫化物; 使用所述新型化合物作为抗氧化剂; 含有它们的药物组合物; 一种制备所述新化合物的方法。 所述新型环状有机硒化合物具有通式（I）：
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Patent Agency Ranking6.发明授权4H-1-benzopyran-4-one derivative or its salt, process for producing the same and pharmaceutical composition comprising the same as active ingredient 失效4H-1-苯并吡喃-4-酮衍生物或其盐，其制备方法和包含其作为活性成分的药物组合物
公开(公告)号：US4954518A
公开(公告)日：1990-09-04
申请号：US255121
申请日：1988-10-07
Applicant: Shuntaro Takano , Chosaku Yoshida , Takihiro Inaba , Keiichi Tanaka , Ryuko Takeno , Hideyoshi Nagaki , Tomoya Shimotori , Shinji Makino
Inventor： Shuntaro Takano , Chosaku Yoshida , Takihiro Inaba , Keiichi Tanaka , Ryuko Takeno , Hideyoshi Nagaki , Tomoya Shimotori , Shinji Makino
IPC: C07D213/70 , A61K31/34 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/425 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/4433 , A61K31/445 , A61P29/00 , C07C311/08 , C07D20060101 , C07D213/62 , C07D213/74 , C07D257/04 , C07D295/12 , C07D295/18 , C07D311/22 , C07D311/24 , C07D311/26 , C07D311/30 , C07D311/36 , C07D311/42 , C07D311/54 , C07D311/56 , C07D311/58 , C07D333/30 , C07D405/00 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/04
CPC classification number: C07D405/04 , C07D311/22 , C07D311/24 , C07D311/30 , C07D311/36 , C07D311/54 , C07D311/56 , C07D405/12 , C07D409/12 , C07D417/04
Abstract: This invention relates to a 4H-1-benzopyran-4-one derivative represented by the formula: ##STR1## or a salt thereof, a process for producing the same and a pharmaceutical composition comprising the same as active ingredient.
Abstract translation: 本发明涉及由下式表示的4H-1-苯并吡喃-4-酮衍生物或其盐，其制备方法和含有该活性成分的药物组合物。
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公开(公告)号：US2492661A
公开(公告)日：1949-12-27
申请号：US71827146
申请日：1946-12-24
Applicant: SOCONY VACUUM OIL CO INC
Inventor： SCHICK JOHN W
IPC: C07D333/30
CPC classification number: C07D333/30
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公开(公告)号：US2492659A
公开(公告)日：1949-12-27
申请号：US70894446
申请日：1946-11-09
Applicant: SOCONY VACUUM OIL CO INC
Inventor： SCHICK JOHN W
IPC: C07D333/30
CPC classification number: C07D333/30
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公开(公告)号：US20080091035A1
公开(公告)日：2008-04-17
申请号：US11900330
申请日：2007-09-11
Applicant: Milton Smith , Robert Maleczka , Ghayoor Chotana , Venkata Kallepalli , Sulagna Paul
Inventor： Milton Smith , Robert Maleczka , Ghayoor Chotana , Venkata Kallepalli , Sulagna Paul
IPC: C07D333/30
CPC classification number: C07F5/025
Abstract: Borylated thiophenes are prepared by the process. The borylated thiophenes are intermediates to thiophene polymers for electronic applications.
Abstract translation: 通过该方法制备硼烷基化噻吩。 硼化噻吩是用于电子应用的噻吩聚合物的中间体。
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10.发明申请Diarylselenide compounds and their use in human or veterinary medicine and in cosmetics 审中-公开二芳基硒化合物及其在人类或兽医学和化妆品中的应用公开(公告)号：US20060014803A1
公开(公告)日：2006-01-19
申请号：US11227185
申请日：2005-09-16
Applicant: Jean-Michel Bernardon , Philippe Diaz
Inventor： Jean-Michel Bernardon , Philippe Diaz
IPC: A61K31/44 , A61K31/426 , A61K31/381 , A61K31/34 , C07D307/56 , C07D333/30
CPC classification number: C07D213/80 , A61K8/58 , A61Q5/00 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C07C391/02
Abstract: The invention concerns novel diarylselenide compounds corresponding to formula (I): and the use thereof in pharmaceutical compositions in human or veterinary medicine (in the treatment of dermatological, rheumatic, cardiovascular and ophthalmologic pathologies in particular), or in cosmetic compositions.
Abstract translation: 本发明涉及对应于式（I）的新型二芳基硒化合物：及其在人或兽医药物（特别是治疗皮肤病学，风湿性，心血管和眼科病理学））或化妆品组合物中的药物组合物中的用途。
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