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公开(公告)号：US20240158348A1
公开(公告)日：2024-05-16
申请号：US18277104
申请日：2022-02-15
申请人： FMC Corporation
IPC分类号： C07D207/12 , A01N25/32 , A01N47/02 , A01P13/00 , C07D211/40
CPC分类号： C07D207/12 , A01N25/32 , A01N47/02 , A01P13/00 , C07D211/40
摘要： Disclosed are compounds of Formula 1, all stereoisomers, N-oxides, and salts thereof,
wherein R1 through R8, Rf, Q and G are as defined in the Disclosure.
Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.-
公开(公告)号：US20240025853A1
公开(公告)日：2024-01-25
申请号：US18239978
申请日：2023-08-30
申请人： FMC CORPORATION
发明人： Andrew Duncan SATTERFIELD , Matthew James CAMPBELL , James Francis BEREZNAK , Guy William WHITTINGHAM , Glynn MITCHELL , Christopher John MATHEWS , James Nicholas SCUTT , James Alan MORRIS , Jonathan Wesley Paul DALLIMORE , Timothy Robert DESSON , Katharine Mary INGRAM , Kenneth LING
IPC分类号： C07D211/40 , C07D401/04 , C07D401/12 , C07D207/277 , C07D207/46 , C07D211/94 , C07D409/12 , C07D471/04 , C07D417/04 , C07D407/04 , C07D495/04 , C07D413/12 , A01N43/36 , A01N43/40
CPC分类号： C07D211/40 , C07D401/04 , C07D401/12 , C07D207/277 , C07D207/46 , C07D211/94 , C07D409/12 , C07D471/04 , C07D417/04 , C07D407/04 , C07D495/04 , C07D413/12 , A01N43/36 , A01N43/40
摘要： Disclosed are compounds of Formula 1, N-oxides of the compounds and salts of the compounds and N-oxides:
wherein R1, R2, R3, R4, R5, R6, Q1, Q2, J, Y1, and Y2 are as defined in the disclosure.
Also disclosed are compositions containing the compounds, N-oxides and salts, and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of such a compound. N-oxide, salt or composition.-
公开(公告)号：US11542457B2
公开(公告)日：2023-01-03
申请号：US16765181
申请日：2018-10-16
申请人： Henkel AG & Co. KGaA
IPC分类号： C11B9/00 , A61K8/49 , A61L9/01 , A61Q5/06 , A61Q15/00 , A61Q19/10 , C07D233/58 , C07D233/60 , C11D3/28 , C11D3/50 , C07D211/36 , C07D211/40 , C07D211/54 , C07D213/60 , C07D213/62
摘要： Heterocycles having odoriferous ketone or odoriferous aldehyde groups may be suitable in compositions comprising washing agents, cleaning agents, cosmetic agents, air care agents, insect repellents, or combinations thereof where the heterocycles release the ketones and aldehydes during hydrolysis. The heterocycle(s) may have the formula:
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公开(公告)号：US11236090B2
公开(公告)日：2022-02-01
申请号：US16821845
申请日：2020-03-17
发明人： Yongzhi Shu
IPC分类号： A61K31/4412 , C07D211/40 , C07D471/04 , A61P35/00 , C07D487/04
摘要： A compound for inhibiting and degrading cyclin-dependent kinase (CDK) is disclosed. The compound is a substituted glutarimide represented by formula I. The compound can be used in the preparation of drugs for treating diseases related to the activity of the CDK.
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公开(公告)号：US20220002245A1
公开(公告)日：2022-01-06
申请号：US17479341
申请日：2021-09-20
发明人： Vitor OLIVEIRA , Ivan POGORELIC , Jean-Paul RODUIT
IPC分类号： C07D211/40 , A61K9/48
摘要： The invention relates to a crystalline form of [(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)-piperidine-3,4,5-triol, processes for the preparation thereof, pharmaceutical compositions containing such a crystalline form, and its use as a medicament, especially as glycolipid biosynthesis inhibitor.
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6.发明授权公开(公告)号：US10337014B2
公开(公告)日：2019-07-02
申请号：US15706041
申请日：2017-09-15
IPC分类号： C07D211/40 , C12N15/113 , A61K9/51 , C07D223/08 , C07D207/12
摘要： The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
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公开(公告)号：US10231973B2
公开(公告)日：2019-03-19
申请号：US15560099
申请日：2016-03-18
申请人： CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. , CENTAURUS BIOPHARMA CO., LTD. , LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
发明人： Xiquan Zhang , Song Tang , Weiwei Feng , Xin Tian , Zhilin Chen , Hongmei Gu , Hongjiang Xu , Fei Liu
IPC分类号： C07D403/12 , C07D405/14 , C07D239/94 , C07D211/40 , C07D401/12 , A61K31/517 , A61K45/06 , A61K31/5377 , A61K31/4427
摘要： The present application relates to maleates of a compound of Formula I, methods for preparing the same, pharmaceutical compositions thereof and uses thereof in the treatment of tumors, such as non-small cell lung cancer, breast cancer, and other malignant tumors.
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公开(公告)号：US20190071403A1
公开(公告)日：2019-03-07
申请号：US16080494
申请日：2017-03-09
发明人： Takaaki TERANISHI , Shinya UESUSUKI , Jun IWATA , Takuya KAMADA , Youhei MUNEI , Satoshi NISHIMURA , Hiroki INOUE , Tetsuya TANAKA , Yuka NAKAMURA , Yusuke FUKUSHIMA , Tomomi KOBAYASHI , Shinya KOUBORI
IPC分类号： C07D213/69 , C07D213/89 , C07D213/74 , C07D211/40 , C07D401/06 , C07D405/06 , C07D413/06 , C07D409/06 , C07D417/06 , A01N43/40 , A01N43/82
摘要： The present invention provides a compound represented by formula (I) (in the formula, R1 to R4 each represent a hydrogen atom, an unsubstituted or G1-substituted C1-6 alkyl group or the like, A represents an oxygen atom or the like, Cy represents a C6-10 aryl group or the like), an N-oxide compound thereof, a tautomer or salt thereof. The present invention also provides an agricultural and horticultural fungicide, harmful organism control agent and insecticidal/acaricidal agent containing at least one compound selected from the group consisting of a compound represented by formula (I), a tautomer and salt thereof, as an active ingredient.
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9.发明申请公开(公告)号：US20180030047A1
公开(公告)日：2018-02-01
申请号：US15507028
申请日：2015-08-26
发明人： Olivier MARTIN , Estelle GALLIENNE-BOIVINEAU , Cyril NICOLAS , Piotr B. HECZKO , Grazyna STOCHEL , Magdalena STRUS , Agnieszka KYZIOL , Diana MIKOLAJCZYK , Agnieszka MACHUL
IPC分类号： C07D471/04 , A61K31/40 , A01N43/36 , C07D211/40 , A61K31/551 , A01N43/40 , A61K31/437 , A01N43/90 , C07D487/04 , C07D207/12 , A61K31/445
摘要： Disclosed are compounds of the following formula I: wherein: m represents an integer being equal to 0, 1, 2, 3, 4, 5 or 6, X represents a simple bond or a radical —CHR1— wherein R1 represents: a hydrogen atom, or a linear or branched, possibly interrupted by up to 3 heteroatoms selected from O, S or N and/or possibly substituted, (C1-C12)-alkyl, R2, R3 and R4 represent independently from each other: a hydrogen atom, or a linear or branched (C1-C12)-alkyl or (C1-C12)-acyl R5 represents: a hydrogen atom, or a linear or branched, possibly substituted, (C1-C13)-alkyl possibly interrupted by up to 3 heteroatoms selected from O, S or N, R6 represents: a hydrogen atom, or a linear or branched possibly substituted (C1-C12)-alkyl, possibly substituted and possibly interrupted by up to 3 heteroatoms selected from O, S or N, for their use as antibacterial drugs.
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10.发明授权Alkylated imino sugars exhibiting glucosidase inhibition and their method of use 有权显示葡糖苷酶抑制的烷基化亚氨基糖及其使用方法公开(公告)号：US09126937B2
公开(公告)日：2015-09-08
申请号：US14388175
申请日：2013-03-27
发明人： Yanming Du , Xiaodong Xu , Hong Ye , Jinhong Chang , Timothy M. Block
IPC分类号： C07D211/40 , A61K31/445 , C07D211/46 , C07D413/06 , C07F9/59
CPC分类号： A61K31/45 , A61K31/4015 , C07D207/12 , C07D211/44 , C07D211/46 , C07D413/06 , C07F9/59
摘要： Pharmaceutical compositions of the invention comprise alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity that include Viral hemorrhagic fevers, and any other diseases involving glucosidase activity.
摘要翻译： 本发明的药物组合物包含在治疗与葡萄糖苷酶活性相关的疾病（包括病毒性出血热）和涉及葡糖苷酶活性的任何其它疾病中具有疾病修饰作用的烷基化亚氨基糖衍生物。
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