公开(公告)号：US20240228425A1

公开(公告)日：2024-07-11

申请号：US18402153

申请日：2024-01-02

申请人： ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD.

发明人： Chunguang DAI ,  Jiajia GUO ,  Lirong ZHANG ,  Guanneng YU ,  Shengkang ZHANG ,  Zhiguo ZHENG

IPC分类号： C07C69/34 ,  C07C69/63

CPC分类号： C07C69/34 ,  C07C69/63 ,  C07C2527/24

摘要： The invention relates to a process for preparing pilocarpine and intermediate compounds therefor. In particular, the present invention relates to key intermediates for the preparation of pilocarpine, i.e., compounds of formula I and formula II, and processes for their preparation. One method is to use malic acid as a raw material, react it with alcohol or sulfate ester first, then react with haloethane, etc. to obtain the compound of formula II, and finally react with a halogenating reagent to obtain the compound of formula I; in the other method, n-butyraldehyde is used as a raw material, and is subjected to condensation reaction, oxidation reaction, esterification reaction and sulfonylation reaction in sequence to obtain the compound of formula II, and finally react with a halogenating reagent to obtain the compound of formula I. The preparation method of the present invention has the advantages of mild reaction conditions, simple reaction process, high overall yield and high purity of the target product, and is therefore very suitable for industrial production.

公开(公告)号：US20210230653A1

公开(公告)日：2021-07-29

申请号：US17142771

申请日：2021-01-06

申请人： ExxonMobil Research and Engineering Company

发明人： Christopher M. Flynn ,  Mark P. Hagemeister

IPC分类号： C12P7/64 ,  C12N9/10 ,  C12N9/06 ,  C07C69/34 ,  C10M105/34

摘要： The present disclosure provides processes for producing alkylated fatty acids and derivatives thereof. In at least one embodiment, a process includes introducing a terminal alkyl transferase and a fatty acid into a bioreactor. The process includes introducing an internal methyl transferase and internal methyl reductase into the bioreactor or a second bioreactor. The process includes obtaining an alkylated fatty acid having a methyl substituent located at an internal carbon atom of the fatty acid and a methyl substituent or ethyl substituent located at a carbon atom alpha to the terminal carbon atom of the fatty acid.

公开(公告)号：US11046635B2

公开(公告)日：2021-06-29

申请号：US15954451

申请日：2018-04-16

申请人： GENOMATICA, INC.

发明人： Zhihao Hu ,  Fernando Valle

IPC分类号： C07C69/533 ,  C12N1/20 ,  C12N1/16 ,  C12N1/14 ,  C12N1/12 ,  C07C69/34 ,  C07C69/52 ,  C10L1/02 ,  C10L1/19 ,  C11C3/00 ,  C12P7/64 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  C12N9/00

摘要： Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.

公开(公告)号：US10851042B2

公开(公告)日：2020-12-01

申请号：US16899432

申请日：2020-06-11

申请人： ELC MANAGEMENT LLC

发明人： Fatemeh Mohammadi ,  Anna Czarnota

IPC分类号： C07C69/70 ,  C07C69/34

摘要： A process for solubilizing a resveratrol glycolate compound by heating the resveratrol glycolate and mixing the resveratrol glycolate with one or more glycols is disclosed. The process comprises an initial heating step of the resveratrol compound to a temperature not greater than 45° C. and a mixing step that mixes the heated resveratrol glycolate compound with at least one glycol solvent at room temperature for ten minutes to one hundred and twenty minutes.

公开(公告)号：US20200339743A1

公开(公告)日：2020-10-29

申请号：US16763825

申请日：2018-11-13

申请人： Dow Global Technologies LLC

发明人： Thiago V. Alonso ,  Callie M. Ayers ,  Stephen M. Hoyles

IPC分类号： C08G63/16 ,  C07C69/34 ,  C07C69/78

摘要： A polyester demulsifier and method of synthesizing said polyester demulsifier including the step of reacting a mixture of polyol and aromatic di-acid, the aromatic di-acid solubilized into said polyol without sublimation or degradation during the reaction process.

公开(公告)号：US20200325301A1

公开(公告)日：2020-10-15

申请号：US16811903

申请日：2020-03-06

申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

发明人： Jihoon SHIN ,  Haemin JEONG ,  Nam-Kyun KIM ,  Young-Wun KIM

IPC分类号： C08K5/11 ,  C07C69/34 ,  C07C67/465

摘要： Disclosed herein is an acetylated lactide oligomer-based plasticizer and a method of preparing the same having improved thermal stability, enhanced plasticity and excellent compatibility with a resin, the method, including: (a) synthesizing a lactide oligomer through ring-opening polymerization (ROP) of an initiator and lactide; (b) putting acetic anhydride into the lactide oligomer and performing acetylation; and (c) removing acetic acid generated in step (b) and unreacted acetic anhydride

公开(公告)号：US10792268B2

公开(公告)日：2020-10-06

申请号：US15451891

申请日：2017-03-07

申请人： University of South Florida

发明人： Dominic Paul D'Agostino ,  Shannon Kesl

IPC分类号： A61K31/225 ,  C07C69/34 ,  C07C69/16 ,  C07C31/20 ,  A61K31/22

摘要： The ketogenic diet (KD) has therapeutic implications in many disease states. It was hypothesized ketone precursor supplementation would elevate blood ketone levels to therapeutic ranges (2-7 mM) without need for dietary restriction. The effects of ketogenic agents were tested on blood glucose, ketones, and lipids with a 28-day dose escalation study in male Sprague-Dawley rats: R,S-1,3-Butandiol (BD), acetoacetate ketone ester (KE), and control (H2O) (n≥8). Days 1-28, rats received a daily 5 g/kg intragastric gavage, based on previous toxicology studies. Once weekly, whole blood samples (10 μl) were acquired for analysis of glucose and βHB at 0, 0.5, 1, 4, 8, and 12 hours after test substance administration, or until βHB returned to baseline. At day 1 and 28, 10 μL of whole blood were collected to measure triglycerides, total cholesterol, and HDL concentration. Significant elevation of blood ketone was observed with a significant inverse relationship with blood glucose for the duration of the experiment. There were no significant changes in the lipid panel for any of the substances. There were significant reductions in body weight when animals were treated with either BD or KE as compared to control.

公开(公告)号：US10710956B2

公开(公告)日：2020-07-14

申请号：US16270351

申请日：2019-02-07

申请人： Regents of the University of Minnesota

发明人： Ian A. Tonks ,  Marc A. Hillmyer ,  Gereon M. Wuu-Yee

IPC分类号： C07C67/32 ,  C07C67/03 ,  B01J31/24 ,  C07C69/54 ,  C07C69/34 ,  C07C69/736

摘要： Catalytic hydroesterification of alkyl lactates give alkyl 2-(propionyloxy)propanoates, starting from alkyl lactate, carbon monoxide, ethylene gas, and a palladium catalyst. Pyrolysis of alkyl 2-(propionyloxy)propanoates gives acrylate esters.

公开(公告)号：US10526273B2

公开(公告)日：2020-01-07

申请号：US16256013

申请日：2019-01-24

申请人： Vanderbilt University

发明人： Prasad L. Polavarapu ,  Vijay Raghavan

IPC分类号： C07C69/34 ,  C07C211/27 ,  C07C69/67 ,  C07C211/63

摘要： Disclosed herein are surfactant compounds, that are surface active, liquid, chiral, and micelle forming. Also disclose herein are ionic liquids and compsitions comprising the surfactant compounds.

公开(公告)号：US10351658B2

公开(公告)日：2019-07-16

申请号：US15936535

申请日：2018-03-27

申请人： Mitsubishi Chemical Corporation

发明人： Teruhiko Ohara ,  Naoki Suzuki ,  Yasuko Nakajima ,  Hiroto Itou ,  Takayuki Aoshima ,  Naoki Sugai ,  Takanao Matsumoto

IPC分类号： A43B1/00 ,  A43B1/14 ,  A43B13/04 ,  C07C69/34 ,  C07C69/40 ,  C07C69/66 ,  C07C69/70 ,  C08G63/06 ,  C08G63/16 ,  C08G63/20 ,  C08G63/60 ,  C07C59/245 ,  C07C69/675 ,  C07C69/704 ,  C08G101/00 ,  C08G18/08 ,  C08G18/42 ,  C08G18/66 ,  C08G18/76 ,  C09D175/06 ,  C09J175/06

摘要： The invention relates to a method for producing a biomass-resource-derived polyurethane, which comprises: reacting a dicarboxylic acid and an aliphatic diol to produce a polyester polyol; and reacting the polyester polyol and a polyisocyanate compound, wherein the dicarboxylic acid contains at least one component derived from biomass resources, a content of an organic acid in the dicarboxylic acid is more than 0 ppm and not more than 1,000 ppm relative to the dicarboxylic acid, and a pKa value of the organic acid at 25° C. is not more than 3.7.