公开(公告)号：US12233416B2

公开(公告)日：2025-02-25

申请号：US18296954

申请日：2023-04-06

Applicant: The University of British Columbia

Inventor： Pieter R. Cullis ,  Igor V. Jigaltsev ,  Robert James Taylor ,  Timothy Leaver ,  Andre Wild ,  Nathan Maurice Belliveau

IPC: A61K9/16 ,  A61J3/00 ,  A61K9/107 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1277 ,  A61K9/14 ,  A61K31/704 ,  A61K47/44 ,  A61K49/00 ,  B01F23/41 ,  B01F25/431 ,  B01F25/433 ,  B01F33/30 ,  B01L3/00

Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.

公开(公告)号：US12233099B2

公开(公告)日：2025-02-25

申请号：US17059122

申请日：2019-05-24

Applicant: GREEN CROSS WELLBEING CORPORATION

Inventor： Sun Kyu Park ,  Jeom Yong Kim ,  Young Hyo Yoo ,  Min Jung Jang ,  Chang Taek Oh ,  Min Ju Lim ,  Gwan Su Yi ,  Yi Li ,  Yoon Hyeok Lee ,  Jae Cheal Yoo

IPC: A61K36/00 ,  A23L33/00 ,  A23L33/105 ,  A61K9/00 ,  A61K31/704 ,  A61K36/258 ,  A61P21/00

Abstract: The present invention relates to a composition for promoting myogenesis, containing, as an active ingredient, a processed ginseng extract in which a trace amount of a ginsenoside ingredient is increased. It has been ascertained that the processed ginseng extract promotes the differentiation of myoblasts into muscle and inhibits muscle atrophy caused by myostatin, which is a myogenesis inhibitory factor, and thus it is expected that a composition for preventing or treating muscle disorder-related diseases, having excellent effects, can be developed.

公开(公告)号：US20250051770A1

公开(公告)日：2025-02-13

申请号：US18723163

申请日：2022-12-20

Applicant: SAPREME TECHNOLOGIES B.V.

Inventor： Miriam Verena BUJNY ,  Ruben POSTEL ,  Guy HERMANS

IPC: C12N15/113 ,  A61K31/704 ,  A61K36/185 ,  A61K47/54 ,  A61K47/61 ,  A61K47/64 ,  A61K47/68 ,  A61P21/00

Abstract: The invention lies in the field of treatment and prophylaxis of muscle wasting disorders, in particular the ones involving a genetic factor that can be targeted by a delivery of a therapeutic nucleic acid into the muscle cells. In line with the latter aspect, disclosed herein are pharmaceutical compositions and advantageous components thereof that substantially enhance the effective delivery and release of a therapeutic nucleic acid into the right internal compartment of the muscle cell, such as the cytosol and/or the nucleus, in which compartment it can reach and act upon its genetic target. As disclosed herein, this substantially enhanced delivery and release is achieved by a provision of an endosomal-escape-enhancing saponin in the disclosed herein pharmaceutical compositions comprising therapeutic nucleic acids and, optionally, muscle cell-targeting ligands conjugated therewith. As for the first time demonstrated herein, these saponin types not only surprisingly retain their endosomal-escape-enhancing properties in fully differentiated muscle cells but also can in an unconjugated state successfully be delivered thereto together with the therapeutic nucleic acids.

公开(公告)号：US20250049829A1

公开(公告)日：2025-02-13

申请号：US18719989

申请日：2022-12-08

Applicant: ISTANBUL MEDIPOL UNIVERSITESI

Inventor： Ramazan KASMER ,  Metehan ILTER ,  Özge SENSOY ,  Nihal KARAKAS ,  Ozan TOPÇU

IPC: A61K31/704 ,  A61K31/196 ,  A61K31/4015 ,  A61K31/4174 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/4725 ,  A61K31/506 ,  G16B15/30

Abstract: Disclosed are therapeutic molecules that can be used as an alternative to SHP2 phosphatase inhibitors, as a novel approach to targeting RAS isoforms with the G12D mutation that is involved in cancer formation.

公开(公告)号：US20250049718A1

公开(公告)日：2025-02-13

申请号：US18904339

申请日：2024-10-02

Applicant: University of Houston System

Inventor： Eva Harth

IPC: A61K9/16 ,  A61K31/337 ,  A61K31/365 ,  A61K31/366 ,  A61K31/40 ,  A61K31/4745 ,  A61K31/519 ,  A61K31/58 ,  A61K31/704

Abstract: Nanoparticles and nanonetworks formed of these nanoparticles are provided. Methods for forming such nanoparticles and nanonetworks are also provided, as well as uses of the nanoparticles and/or nanonetworks, including their use for drug delivery.

公开(公告)号：US12215390B2

公开(公告)日：2025-02-04

申请号：US18056967

申请日：2022-11-18

Applicant: BIOTHERANOSTICS, INC.

Inventor： Yi Zhang ,  Catherine A. Schnabel

IPC: C12Q1/6886 ,  A61K31/337 ,  A61K31/513 ,  A61K31/675 ,  A61K31/704 ,  A61K45/06

Abstract: Methods of determining risk of recurrence of a breast cancer of a subject are provided. Also provided are methods of predicting responsiveness to a therapy of a breast cancer of a subject. Additionally, methods of recommending treatment for a subject that has breast cancer are provided. Further provided are methods of treating a subject that has breast cancer. Systems for performing described methods are also provided.

公开(公告)号：US12208164B2

公开(公告)日：2025-01-28

申请号：US17434363

申请日：2020-02-27

Applicant: UNM Rainforest Innovations

Inventor： C. Jeffrey Brinker ,  Jimin Guo ,  Wei Zhu

IPC: A61K9/107 ,  A61K31/704 ,  A61K33/242 ,  A61K47/10 ,  A61K47/24 ,  A61K47/68 ,  A61K47/69 ,  A61P35/00

Abstract: A method to prepare a population of metal-organic polyhedra (MOP) supported micelle nanoparticles (NPs), and a composition comprising MOP supported micelle NPs, are provided.

公开(公告)号：US12201620B2

公开(公告)日：2025-01-21

申请号：US17688222

申请日：2022-03-07

Applicant: The Brigham And Women's Hospital, Inc.

Inventor： Josephine Kahn ,  Siddhartha Jaiswal ,  Benjamin Ebert

IPC: A61K31/4436 ,  A61K31/381 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/243 ,  A61P35/00

Abstract: The present invention features methods for increasing sensitivity and/or reversing resistance to chemotherapy, methods for treating or preventing a cancer in a subject, methods for treating clonal hematopoiesis of indeterminate potential in a subject, and methods of identifying resistance or sensitivity to chemotherapy in a subject. In some embodiments, the methods contain the step of administering an agent that inhibits the expression or activity of a Protein phosphatase 1D (PPM1D) polypeptide or polynucleotide. The present invention also features compositions for increasing sensitivity and/or reversing resistance to chemotherapy.

公开(公告)号：US12195531B2

公开(公告)日：2025-01-14

申请号：US16568702

申请日：2019-09-12

Applicant: CODE BIOTHERAPEUTICS, INC. ,  Lankenau Institute of Medical Research

Inventor： Robert C. Getts ,  James Kadushin ,  Mindy George-Weinstein ,  Jacquelyn Gerhart ,  Emanuela Dylgjeri ,  Kelly Rhodes

IPC: C07K16/28 ,  A61K9/51 ,  A61K31/704 ,  A61K31/713 ,  A61K47/54 ,  A61K47/62 ,  A61K47/68 ,  A61K47/69

Abstract: Compositions and methods for targeted delivery of active agents to cells are provided. The compositions comprise a wholly or partially double-stranded synthetic DNA carrier, and an active agent intercalated in double-stranded portions of the DNA carrier. The DNA carrier may also be linked to a targeting agent. The compositions are useful for delivering an active agent into a targeted cell type, for example a cytotoxic agent.

公开(公告)号：US12194063B2

公开(公告)日：2025-01-14

申请号：US18433467

申请日：2024-02-06

Applicant: BEIJING UNIVERSITY OF CHINESE MEDICINE

Inventor： Anlong Xu ,  Hongmei Li

IPC: A61K35/60 ,  A61K31/343 ,  A61K31/661 ,  A61K31/704 ,  A61K31/7048 ,  A61K35/30 ,  A61K35/32 ,  A61K35/50 ,  A61K36/258 ,  A61K36/28 ,  A61K36/296 ,  A61K36/424 ,  A61K36/481 ,  A61K36/537 ,  A61K38/02 ,  A61K38/18 ,  A61P9/00

Abstract: The invention discloses a traditional Chinese medicine mixture with a function of promoting directional differentiation of stem cells into cardiomyocytes, which comprises syngnathus, cornu cervi pantotrichum, hippocampus, ginseng, astragalus, epimedium, placenta hominis, salvia miltiorrhiza, gynostemma pentaphyllum and saussurea involucrata. The invention discloses a traditional Chinese medicine effective ingredient compound with a function of promoting directional differentiation of stem cells into cardiomyocytes. The invention further discloses a chemical compound with a function of promoting directional differentiation of stem cells into cardiomyocytes, which is a brand-new chemical compound from a mixture of velvet antler polypeptide, a syngnathus extract and a hippocampus extract—a new isomer of iridoid glycoside Scropolioside D. The invention further discloses uses of the mixture, the compound and the chemical compound in preparation of a drug or a kit for promoting directional differentiation of stem cells into cardiomyocytes and in scientific research.