公开(公告)号：US20230149456A1

公开(公告)日：2023-05-18

申请号：US17916193

申请日：2021-03-30

Applicant: Rita E. Serda ,  Jimin Guo ,  Achraf Noureddine ,  Stefan A. Franco ,  Henning DeMay ,  UNM RAINFOREST INNOVATIONS

Inventor： Rita E. Serda ,  Jimin Guo ,  Achraf Noureddine ,  Stefan A. Franco ,  Henning DeMay

IPC: A61K35/13 ,  B82Y5/00 ,  A61K35/74 ,  A61K35/76

CPC classification number: A61K35/13 ,  B82Y5/00 ,  A61K35/74 ,  A61K35/76

Abstract: A silicified cell includes a nanoparticle that carries a bioactive agent. The silicified call can be a tumor cell, a bacterial cell, a virus, or a silicifiable compartment or fragment thereof. The silicified cell can optionally include an immunomodulatory moiety that may be carried within pores of the nanoparticle and/or bound to the surface of the nanoparticle. The silicified cell can be used as a prophylactic or therapeutic treatment for treating tumors or bacterial infections.

公开(公告)号：US12201651B2

公开(公告)日：2025-01-21

申请号：US17436872

申请日：2020-03-03

Applicant: UNM RAINFOREST INNOVATIONS

Inventor： Rita E. Serda ,  Jimin Guo

IPC: A61K35/13 ,  C12N5/00 ,  C12N5/09

Abstract: A pharmaceutical composition includes a silicified cell or fraction thereof, a cationic layer disposed on at least a portion of the surface of the silicified cell or fraction thereof, and an immunomodulatory moiety bound to at least a portion of the cationic layer. Alternatively, the pharmaceutical composition includes a silicified cell or fraction thereof, a cationic layer disposed on at least a portion of the surface of the silicified cell or fraction thereof, an anionic layer disposed on at least a portion of the cationic layer, and an immunomodulatory moiety bound to at least a portion of the anionic layer.

公开(公告)号：US20220125835A1

公开(公告)日：2022-04-28

申请号：US17436872

申请日：2020-03-03

Applicant: Rita E. Serda ,  Jimin Guo ,  UNM RAINFOREST INNOVATIONS

Inventor： Rita E. Serda ,  Jimin Guo

IPC: A61K35/13 ,  C12N5/00 ,  C12N5/09

Abstract: A pharmaceutical composition includes a silicified cell or fraction thereof, a cationic layer disposed on at least a portion of the surface of the silicified cell or fraction thereof, and an immunomodulatory moiety bound to at least a portion of the cationic layer. Alternatively, the pharmaceutical composition includes a silicified cell or fraction thereof, a cationic layer disposed on at least a portion of the surface of the silicified cell or fraction thereof, an anionic layer disposed on at least a portion of the cationic layer, and an immunomodulatory moiety bound to at least a portion of the anionic layer.

公开(公告)号：US12208164B2

公开(公告)日：2025-01-28

申请号：US17434363

申请日：2020-02-27

Applicant: UNM Rainforest Innovations

Inventor： C. Jeffrey Brinker ,  Jimin Guo ,  Wei Zhu

IPC: A61K9/107 ,  A61K31/704 ,  A61K33/242 ,  A61K47/10 ,  A61K47/24 ,  A61K47/68 ,  A61K47/69 ,  A61P35/00

Abstract: A method to prepare a population of metal-organic polyhedra (MOP) supported micelle nanoparticles (NPs), and a composition comprising MOP supported micelle NPs, are provided.

公开(公告)号：US20240139299A1

公开(公告)日：2024-05-02

申请号：US18404430

申请日：2024-01-04

Applicant: UNM Rainforest Innovations

Inventor： Rita E. Serda ,  C. Jeffrey Brinker ,  Jacob Ongudi Agola ,  Jimin Guo ,  Sarah Adams

IPC: A61K39/00 ,  A61K39/39

CPC classification number: A61K39/0011 ,  A61K39/39 ,  A61K2039/55594 ,  A61K2039/6006

Abstract: A silicified cell replica includes a silicified cell or a silicified subcellular fragment. The silicified cell replica may be used to induce an immunological response, treat a bacterial infection, or treat a patient with cancer.

公开(公告)号：US11896653B2

公开(公告)日：2024-02-13

申请号：US16647245

申请日：2018-09-13

Applicant: UNM Rainforest Innovations

Inventor： Rita E. Serda ,  C. Jeffrey Brinker ,  Jacob Ongudi Agola ,  Jimin Guo ,  Sarah Adams

IPC: A61K39/00 ,  A61K39/39

CPC classification number: A61K39/0011 ,  A61K39/39 ,  A61K2039/55594 ,  A61K2039/6006

Abstract: A silicified cell replica includes a silicified cell or a silicified subcellular fragment. The silicified cell replica may be used to induce an immunological response, treat a bacterial infection, or treat a patient with cancer.

公开(公告)号：US20230138721A1

公开(公告)日：2023-05-04

申请号：US17916115

申请日：2021-03-30

Applicant: UNM RAINFOREST INNOVATIONS

Inventor： Rita E. Serda ,  Jimin Guo ,  Achraf Noureddine ,  Stefan A. Franco ,  Henning DeMay

IPC: A61K47/69 ,  C01B33/18 ,  A61K47/64 ,  A61K47/61 ,  A61K47/60

Abstract: A mesoporous silica nanoparticle includes a plurality of pores, a bioactive agent disposed in at least a portion of the ores, and an immunomodulatory moiety either disposed in a portion of the pores or bound to at least a portion of the outer surface of the nanoparticle.