公开(公告)号：US4230685A

公开(公告)日：1980-10-28

申请号：US015895

申请日：1979-02-28

Applicant: Andrew E. Senyei ,  Kenneth J. Widder

Inventor： Andrew E. Senyei ,  Kenneth J. Widder

IPC: G01V3/08 ,  A61K35/12 ,  C12N1/02 ,  C12N7/02 ,  G01N27/72 ,  G01N33/543 ,  G01N33/544 ,  G01N33/553 ,  G01N31/00 ,  G01N21/46

CPC classification number: C12N7/00 ,  A61K35/12 ,  C12N1/02 ,  G01N33/5434 ,  G01N33/544 ,  C12N2710/16051 ,  G01N2333/31 ,  G01N2333/76 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/84 ,  Y10S436/828

Abstract: Magneticaly-responsive microspheres having Protein A associated with the outer surfaces thereof are reacted with antibodies selective to the cells, bacteria, or viruses to be separated from a mixed population to attach the antibodies in oriented relation with their Fab arms extending outwardly, and the microspheres are then used in a magnetic separation procedure. The preferred microspheres are prepared from a mixture of albumin, Protein A, and magnetic particles, the microspheres being prepared so that the Protein A is present in the exterior surfaces for antibody binding.

Abstract translation: 与其外表面相关的具有蛋白A的磁性响应性微球与与细胞，细菌或病毒有选择性的抗体与混合群体分离反应，以将抗体与其Fab臂向外延伸的定向关系附着，并且微球 然后在磁力分离过程中使用。 优选的微球由白蛋白，蛋白A和磁性颗粒的混合物制备，制备微球体使蛋白A存在于外表面用于抗体结合。

公开(公告)号：US4188116A

公开(公告)日：1980-02-12

申请号：US879315

申请日：1978-02-21

Applicant: Stephen A. Bartfay-Szabo

Inventor： Stephen A. Bartfay-Szabo

IPC: G01N21/43 ,  G01N21/46

CPC classification number: G01N21/43

Abstract: A follower mechanism is used to determine the precise location of a moveable mirror in an Abbe Refractometer to provide the necessary information for converting mirror position to index of refraction. The mechanism is particularly suitable for conversion and readout by electronic means.

Abstract translation: 随动机构用于确定阿贝折射仪中可移动镜的精确位置，以提供将镜像位置转换为折射率的必要信息。 该机构特别适用于电子方式的转换和读出。

公开(公告)号：US4181434A

公开(公告)日：1980-01-01

申请号：US802741

申请日：1977-06-02

Applicant: Robert J. Meltzer

Inventor： Robert J. Meltzer

IPC: G01N21/43 ,  G01N21/46

CPC classification number: G01N21/43

Abstract: The effect of angular errors or mismatching indices of refraction of color-compensation prisms of Abbe refractometers can be virtually eliminated by decentration of the lens used to image light on the refractometer reticle.

Abstract translation: 阿贝折射仪的色彩补偿棱镜的角度误差或不匹配折射率的影响可以通过用于折射仪掩模版上的图像光的透镜的偏心实际上消除。

公开(公告)号：US4037967A

公开(公告)日：1977-07-26

申请号：US465241

申请日：1974-04-29

Applicant: Walter Schweizer ,  Martin-Ulrich Reissland

Inventor： Walter Schweizer ,  Martin-Ulrich Reissland

IPC: G01N9/24 ,  G01N21/43 ,  H01M10/48 ,  G01N21/46

CPC classification number: G01N21/431 ,  H01M10/484

Abstract: An apparatus for continuously measuring the density of a liquid within prespecified limits, utilizing the law of refraction, particularly an apparatus for measuring the acid density of a motor vehicle storage battery for the purpose of determining its state of charge. The apparatus has an optical system with a photosensitive element and a light transmissive body with a measuring surface which is in contact with the liquid, and with a light source which illuminates the measuring surface.The light source has an illuminated surface with a non-directional transmission.The illuminated surface facing the measuring surface is spaced therefrom.The illuminating surface together with said measuring surface define an open container filled with the said liquid. A frosted glass disc illuminated by a lamp forms the illuminated surface.The optical system contains a convergent lens whose main plane, together with the measuring surface encloses a precisely defined acute angle.

公开(公告)号：US3975097A

公开(公告)日：1976-08-17

申请号：US525540

申请日：1974-11-20

Applicant: Wallace Louis Minto

Inventor： Wallace Louis Minto

IPC: G01N21/41 ,  G01N21/46 ,  G01N21/48

CPC classification number: G01N21/41

Abstract: An apparatus for measuring the index of refraction of a specimen includes a stage plate having a small exposure opening behind which are located a point source infra-red light emitting diode and a photoresistor. A first lens focusses the LED point source along a first optical axis at the exposure opening on the plane of the specimen receiving face of the stage plate defining a sensing area and a second lens focusses the image on the sensing area along a second optical axis onto the photoresistor. The optical axes form equal angles to the perpendicular to the exposure plane at the center of the sensing area. The light emitting diode and the photoresistor are connected through a common normally open switch to a battery.

Abstract translation: 用于测量试样折射率的装置包括具有小曝光开口的平台板，位于其上的点源红外发光二极管和光敏电阻器。 第一透镜在限定感测区域的台板的样本接收面的平面上的曝光开口处沿着第一光轴聚焦LED点源，并且第二透镜将沿着第二光轴的感测区域上的图像聚焦到 光敏电阻 光轴与感测区域中心处的曝光平面的垂直线成等角度。 发光二极管和光敏电阻通过公共常开开关连接到电池。

公开(公告)号：US3962581A

公开(公告)日：1976-06-08

申请号：US619677

申请日：1975-10-06

Applicant: William E. Zimmerman

Inventor： William E. Zimmerman

IPC: G01N21/35 ,  G01N33/18 ,  G01N21/00 ,  G01N21/26 ,  G01N21/34 ,  G01N21/46

CPC classification number: G01N33/18 ,  G01N21/3577 ,  G01N21/3563

Abstract: The consistency of solid particles in an aqueous fluid suspension may be measured over the range of 0.20 to 20% from the magnitude of electrical power generated by a 0.35 to 1.05 micron light spectrum responsive silicon photocell that is energized by a low, constant power incandescent light source. Light from the source is reflected from the suspension flow stream. The reflected light is filtered to block passage of wave-lengths less than 0.70 microns to the photocell. Angular disposition of the photocell relative to the light path is adjusted to emphasize either a direct relationship between cell power and consistency changes or an inverse relationship thereof.

Abstract translation: 固体颗粒在水性液体悬浮液中的稠度可以在从由0.35至1.05微米光谱响应的硅光电池产生的电功率的大小的0.20至20％的范围内测量，所述光谱响应硅光电池被低功率恒定功率的白炽灯 资源。 来自源的光从悬浮液流反射。 过滤反射光以阻挡波长小于0.70微米的光通量。 调整光电管相对于光路的角度配置以强调单元功率与一致性变化之间的直接关系或其反向关系。

公开(公告)号：US3864577A

公开(公告)日：1975-02-04

申请号：US41349773

申请日：1973-11-07

Applicant: BRITISH PETROLEUM CO

Inventor： PELLETT JACQUES PIERRE ,  BAISAN HENRI BERNARD ANDRE ,  LIEVAUX JEAN ,  PATCHETT GEORGES

IPC: G01F23/292 ,  G01N21/46

CPC classification number: G01F23/2924

Abstract: Tank filling monitor based on the attenuation of a light signal transmitted by an isosceles prism with total internal reflection as the prism is progressively immersed in a liquid of differing refractive index from the atmosphere. Optical fibres of appropriate length may be used to convey the incident light from the source to the prism and from the prism to a light detector.

Abstract translation: 基于由具有作为棱镜的全内反射的等腰棱镜传输的光信号的衰减的罐充填监视器逐渐浸入与大气不同的折射率的液体中。 适当长度的光纤可以用于将来自源的入射光传送到棱镜并从棱镜传送到光检测器。

公开(公告)号：US3746450A

公开(公告)日：1973-07-17

申请号：US3746450D

申请日：1972-06-26

Applicant: AMERICAN OPTICAL CORP

Inventor： SMITH L

IPC: G01M11/02 ,  G01N21/43 ,  G01N21/46 ,  G01B9/00

CPC classification number: G01N21/43 ,  G01M11/02

Abstract: Glass ophthalmic lenses which have been treated by a process of ion exchange provide increased impact resistance and durability. It is necessary that these lenses be inspected to ascertain that the desired penetration of the ion exchange process has occurred prior to dispensing the lenses to the public. This may now be accomplished by introducing into the hardened exterior layer light waves at essentially grazing refraction. Because the hardened outer layer is of compressively stressed nature, the resulting index of refraction is generally higher than that of the interior of the lens. These light waves which were introduced at essentially grazing refraction are confined to the compressively stressed layer and are guided along the surface in a surface wave mode. The surface wave mode energy may be refracted out of the surface layer to provide a positive output signal. If the hardened layer is not present, these rays will not be guided along the surface of the lens but rather will penetrate into the interior of the lens and will provide no output.

Abstract translation: 已经通过离子交换方法处理的玻璃眼镜片提供了增加的抗冲击性和耐久性。 在将镜片分配给公众之前，必须检查这些透镜以确定离子交换过程的所需穿透。 现在可以通过在基本上放牧折射中引入硬化的外部层光波来实现。 由于硬化的外层具有压缩应力性质，因此所得到的折射率通常高于透镜内部的折射率。 基本上放射折射引入的这些光波被限制在压缩应力层上，并以表面波模式沿表面引导。 表面波模式能量可以折射出表面层，以提供正输出信号。 如果硬化层不存在，则这些光线将不会沿着透镜的表面被引导，而是将穿透透镜的内部并且不提供输出。

公开(公告)号：US3628867A

公开(公告)日：1971-12-21

申请号：US3628867D

申请日：1969-08-20

Applicant: ANACON INC

Inventor： BRADY TYSON H

IPC: G01N21/43 ,  G01N21/46

CPC classification number: G01N21/43

Abstract: A critical angle refractometer for measuring the refractive index of a liquid of the type having a light source arranged to direct a light beam through a prism to a prism-liquid interface, and a detector for receiving light reflected from the interface and producing a signal indicative of the position of the critical angle, is improved by having mounting structure providing linear guides spaced from the prism and extending substantially parallel to the outer surface of the prism, a carrier member for the detector, and adjusting means for moving the carrier member along the guides, thereby moving the detector in a path substantially perpendicular to the mean reflected light path from the prism. Where moving streams are being monitored, structure is provided for directing the stream at and away from the prism face at acute angles thereto and establishing a continuously moving liquid stream across the prism face therebetween. A novel sample-type refractometer is also described.

公开(公告)号：US3623361A

公开(公告)日：1971-11-30

申请号：US3623361D

申请日：1969-11-04

Applicant: NASA

Inventor： FUNK BUFORD H JR

IPC: G01F1/66 ,  G01P3/80 ,  G01P5/00 ,  G01P5/20 ,  G01M9/00 ,  G01N21/46

CPC classification number: G01P3/806 ,  G01F1/661 ,  G01P5/00 ,  G01P5/20

Abstract: METHOD AND APPARATUS FOR OPTICAL SENSING OF SUPERSONIC FLOWS BY CORRELATING DEFLECTIONS IN LASER BEAMS THROUGH THE FLOW. DEFLECTIONS IN THE LASER BEAMS ARE CONVERTED INTO MEANINGFUL ELECTRICAL SIGNALS BY USE OF A KNIFE-EDGE BEFORE A PHOTODETECTOR, AND THE KNIFE-EDGE IN ROTATABLE WHEREBY BOTH THE TRANSLATIONAL AND ROTATIONAL MOTION OF TURBULENT FLOW STRUCTURES MAY BE DETERMINED