Non-invasive blood glucose monitoring by interferometry
    1.
    发明授权
    Non-invasive blood glucose monitoring by interferometry 失效
    通过干涉测量进行非侵入性血糖监测

    公开(公告)号:US06836337B2

    公开(公告)日:2004-12-28

    申请号:US10247753

    申请日:2002-09-19

    申请人: Tom N. Cornsweet

    发明人: Tom N. Cornsweet

    IPC分类号: G01B902

    摘要: The glucose concentration in the bloodstream is directly correlated to the concentration of glucose in the aqueous humor. Furthermore, variation in the glucose concentration in the aqueous humor will cause like variations in its index of refraction. Thus, by measuring the refractive index of the aqueous humor, the glucose concentration in the blood can be determined. The refractive index of the aqueous humor can be measured by interferometry. In various embodiments of the invention that employ interferometry, two beams may be directed onto the eye and caused to interfere, thereby producing a fringe pattern. The fringe pattern may be analyzed to determine the index of refraction of the aqueous humor in the eye and the glucose concentration therein. The glucose level in the blood can be ascertained from this information.

    摘要翻译: 血液中的葡萄糖浓度与房水中的葡萄糖浓度直接相关。 此外,房水中葡萄糖浓度的变化将导致其折射率的类似变化。 因此,通过测量房水的折射率,可以确定血液中的葡萄糖浓度。房水的折射率可以通过干涉测量来测量。 在采用干涉测量的本发明的各种实施例中,两个光束可以被引导到眼睛上并导致干涉,从而产生条纹图案。 可以分析条纹图案以确定眼睛中房水的折射指数和其中的葡萄糖浓度。 可以从该信息确定血液中的葡萄糖水平。

    Fourier transform spectrometer using an optical block
    2.
    发明授权
    Fourier transform spectrometer using an optical block 失效
    傅里叶变换光谱仪使用光学块

    公开(公告)号:US06836333B1

    公开(公告)日:2004-12-28

    申请号:US10031948

    申请日:2002-06-21

    IPC分类号: G01B902

    CPC分类号: G01J3/453

    摘要: The invention concerns an interferometric optical block for Fourier Transform spectrometers having three planar nominally parallel surfaces with the two outer surfaces adapted to act as beam reflectors for internal light and the third surface in operation acting as a beam splitter and beam combiner, the optical block having an input portion by means of which an input beam of light to be analysed can be input so as partially to pass through said third surface to be internally reflected by one of said outer reflectors, and partially to be reflected by said third surface so as then to be internally reflected by the other of said outer reflectors whereby light internally reflected by said outer reflectors is combined at said third surface to produce an exit beam, and wherein said outer surfaces have an inclination with respect to one another so as to make a variation in path lengths in the light forming the exit beam so as to generate an interference fringe field.

    摘要翻译: 本发明涉及一种用于傅里叶变换光谱仪的干涉光学块,其具有三个平面名义上平行的表面,其两个外表面适于充当用于内部光的射束反射器,并且第三表面在操作中用作分束器和光束组合器,该光学块具有 输入部分,通过该输入部分可以输入待分析的输入光束,以便部分地穿过所述第三表面以由所述外部反射器中的一个反射,并且部分地被所述第三表面反射,从而 由所述外部反射器中的另一个内部反射,由此由所述外部反射器内部反射的光在所述第三表面处组合以产生出射光束,并且其中所述外表面相对于彼此具有倾斜度,以使其变化 在形成出射光束的光的路径长度上,以产生干涉条纹场。

    Multi-axis interferometer
    3.
    发明授权
    Multi-axis interferometer 有权
    多轴干涉仪

    公开(公告)号:US06819434B2

    公开(公告)日:2004-11-16

    申请号:US10351708

    申请日:2003-01-27

    申请人: Henry A. Hill

    发明人: Henry A. Hill

    IPC分类号: G01B902

    摘要: An apparatus includes a multi-axis interferometer for measuring changes in a position of a measurement object. The interferometer is configured to receive a progenitor input beam, direct a first angle-measuring beam derived from the progenitor input beam to make a pass to a first point on the measurement object, direct a second angle-measuring beam derived from the progenitor input beam to make a pass to a second point on the measurement object, and then combine the angle-measuring beams to produce an angle-measuring output beam, wherein each angle-measuring beam makes only a single pass to the measurement object before being combined to form the angle-measuring output beam. The interferometer is further configured to direct another set of beams derived from the progenitor input beam along different paths and then combine them to produce another output beam comprising information about changes in the position of the measurement object.

    摘要翻译: 一种装置包括用于测量测量对象位置变化的多轴干涉仪。 所述干涉仪被配置为接收祖先输入光束,引导源自所述祖细胞输入光束的第一角度测量光束以通过所述测量对象上的第一点,引导源自所述祖先输入光束的第二角度测量光束 使测量对象的第二点通过,然后组合角度测量光束以产生角度测量输出光束,其中每个角度测量光束在组合之前仅对测量对象进行单次通过以形成 角度测量输出光束。 干涉仪还被配置成引导来自不同路径的从祖先输入光束导出的另一组光束,然后将它们组合以产生包括关于测量对象的位置变化的信息的另一输出光束。

    Fiber optic interferometric vital sign monitor for use in magnetic resonance imaging, confined care facilities and in-hospital
    4.
    发明授权
    Fiber optic interferometric vital sign monitor for use in magnetic resonance imaging, confined care facilities and in-hospital 有权
    用于磁共振成像,密闭护理设施和医院内的光纤干涉测量生命体征监测仪

    公开(公告)号:US06816266B2

    公开(公告)日:2004-11-09

    申请号:US10299414

    申请日:2002-11-19

    IPC分类号: G01B902

    摘要: A fiber optic monitor that utilizes optical phase interferometry to monitor a patient's vital signs such as respiration, cardiac activity, blood pressure and body's physical movement. The monitor, which is non-invasive, comprises an optical fiber interferometer that includes an optical fiber proximately situated to the patient so that time varying acousto-mechanical signals from the patient are coupled into the optical fiber. Responsive thereto, the interferometer generates a time-varying optical intensity resulting from the interference of optical signals, which are detected at a photo-detector. A signal processor coupled to the optical detector provides one or more processed output signals indicative of the vital functions. The monitor system has broad applicability, from routine monitoring of infants at home to detection of apnea, arrhythmia, blood pressure and trauma. The system can be implemented in embodiments ranging from a low cost in-home monitor for infants to a high end product for in hospital use. The monitor can be integrated with other sensors such as an EKG, a video or still camera, an oxygen sensor, a carbon dioxide sensor, temperature sensor or a microphone to get additional required information depending on the application. When integrated and combined with EKG information, the monitor provides ballisto-mechanical information of the heart for early diagnosis of cardiac conditions or prediction of events or for correcting corrupted EKG signals due to time varying magnetic and electric fields. In some embodiments of the monitor, the system can be made portable so that the patient can walk around while still being continuously monitored for vital signs. Another suitable design measures blood pressure continuously and non-invasively by containing the fiber optic sensor in a cuff that wraps around an arterial wall of the patient. The fiber optic monitor may be designed for use in a variety of settings including an operating room, a recovery room, an intensive care unit, a magnetic resonance imaging laboratory, a computerized tomography scan laboratory and an elderly care facility.

    Interferometric measurement apparatus for wavelength calibration
    5.
    发明授权
    Interferometric measurement apparatus for wavelength calibration 有权
    用于波长校准的干涉测量装置

    公开(公告)号:US06816263B2

    公开(公告)日:2004-11-09

    申请号:US10189198

    申请日:2002-07-05

    IPC分类号: G01B902

    CPC分类号: G01J9/0246

    摘要: The present invention concerns an interferometric measurement apparatus for wavelength calibration, having a laser light source (1), a detector (2), and an interferometer (3), the laser light source (1) emitting light of at least one wavelength, the interferometer (3) separating the light of the laser light source (1) into two sub-beams (4, 5)—a reference beam (4) and a measurement beam (5)—and combining the sub-beams (4, 5) again after at least one reflection at one reflection means (6) each, and the path length difference between the reference beam (4) and measurement beam (5) defining a constant wavelength calibration distance. In order to increase the measurement accuracy and reduce measurement errors, the measurement beam distance can be extended, but without causing problems in terms of manufacture, assembly, and/or alignment. The interferometric measurement apparatus according to the present invention is characterized in that at least one additional reflection means (8), which reflects the measurement beam (5) at least largely in the opposite direction, is provided in the beam path of the measurement beam (5).

    摘要翻译: 本发明涉及一种用于波长校准的干涉测量装置,具有激光光源(1),检测器(2)和干涉仪(3),激光光源(1)发射至少一个波长的光, 干涉仪(3)将激光光源(1)的光分成两个子光束(4,5) - 参考光束(4)和测量光束(5),并将子光束(4,5) )在每个反射装置(6)上的至少一次反射之后再次进行,并且参考光束(4)和测量光束(5)之间的路径长度差定义恒定的波长校准距离。 为了提高测量精度并减少测量误差,可以延长测量光束的距离,但不会在制造,组装和/或对准方面产生问题。 根据本发明的干涉测量装置的特征在于,在测量光束的光束路径中设置至少一个在相反方向上反射测量光束(5)的附加反射装置(8) 5)。

    Interferometric cyclic error compensation
    6.
    发明授权
    Interferometric cyclic error compensation 有权
    干涉循环误差补偿

    公开(公告)号:US06806961B2

    公开(公告)日:2004-10-19

    申请号:US10287898

    申请日:2002-11-05

    申请人: Henry A. Hill

    发明人: Henry A. Hill

    IPC分类号: G01B902

    摘要: The invention features an interferometry method including: directing two beams derived from a common source along different paths; producing a first output beam derived from a first portion of each of the two beams; producing a second output beam derived from a second portion of each of the two beams; and calculating a product of a first signal derived from the first output beam and a second signal derived from the second output beam.

    摘要翻译: 本发明的特征在于一种干涉测量方法,包括:沿着不同的路径引导从公共源导出的两个光束; 产生从所述两个光束中的每一个的第一部分导出的第一输出光束; 产生从所述两个光束中的每一个的第二部分导出的第二输出光束; 以及计算从第一输出光束导出的第一信号和从第二输出光束导出的第二信号的乘积。

    Compact beam re-tracing optics to eliminate beam walk-off in an interferometer
    7.
    发明授权
    Compact beam re-tracing optics to eliminate beam walk-off in an interferometer 有权
    紧凑型光束重新跟踪光学元件,以消除干涉仪中的光束偏移

    公开(公告)号:US06806960B2

    公开(公告)日:2004-10-19

    申请号:US10285058

    申请日:2002-10-30

    IPC分类号: G01B902

    摘要: A multi-axis interferometer uses a combined beam for a first pass through the interferometer optics. Measurement and reference components of the combined beam that exit the interferometer optics are subject to walk-off that measurement or reference reflector misalignment can cause. A return reflector and non-polarizing beam splitter system split the combined beam into separated input beams for the various axes of the interferometer and return the separated beams for respective second passes through the interferometer optics. Walk-off for the separated beams in the interferometer optics cancels the walk-off for the combined beam to eliminate beam walk-off in separated output beams. Sharing a combined beam for a first pass through the interferometer optics reduces the sizes required for the interferometer optics and reference and measurement mirrors. The multi-axis interferometer may have a single return reflector.

    摘要翻译: 多轴干涉仪使用组合光束进行第一次通过干涉仪光学元件。 离开干涉仪光学元件的组合光束的测量和参考分量可能导致测量或参考反射器不对准可能导致的偏离。 返回反射器和非偏振分束器系统将组合的光束分成用于干涉仪的各个轴的分离的输入光束,并且将分离的光束返回用于相应的第二次通过干涉仪光学器件。 在干涉仪光学元件中的分离光束的偏离消除组合光束的散射以消除分离的输出光束中的光束偏移。 共享用于第一遍的组合光束通过干涉仪光学器件减少干涉仪光学元件和参考和测量镜所需的尺寸。 多轴干涉仪可以具有单个返回反射器。

    Method and devices for inspecting and calibrating of stereoscopic endoscopes
    8.
    发明授权
    Method and devices for inspecting and calibrating of stereoscopic endoscopes 有权
    用于检查和校准立体内窥镜的方法和装置

    公开(公告)号:US06801325B2

    公开(公告)日:2004-10-05

    申请号:US10183976

    申请日:2002-06-25

    IPC分类号: G01B902

    CPC分类号: G01M11/00

    摘要: Methods and devices for inspecting and calibrating a stereoscopic imaging device, such as a binocular endoscope. In one exemplary embodiment, the method of the present invention measures a fringe pattern from light emitted through two channels of the device. An angle of each of the fringe pattern can be measured so as to allow a diopter difference between the channels to be calculated.

    摘要翻译: 用于检查和校准诸如双目内窥镜的立体成像装置的方法和装置。 在一个示例性实施例中,本发明的方法从通过设备的两个通道发射的光测量条纹图案。 可以测量每个条纹图案的角度,以便计算通道之间的屈光度差异。

    Wavelength measurement adjustment
    9.
    发明授权
    Wavelength measurement adjustment 失效
    波长测量调整

    公开(公告)号:US06798522B2

    公开(公告)日:2004-09-28

    申请号:US09922115

    申请日:2001-08-03

    IPC分类号: G01B902

    摘要: A wavelength-determining unit for determining the wavelengths of a plurality of successive optical signals &lgr;(t) includes a wavemeter unit for determining first wavelength values &lgr;1(t) for the optical signals &lgr;(t). An absolute-measuring unit having unambiguous wavelength properties at known absolute wavelength values determines second wavelength values &lgr;2(t) as such of the known absolute wavelength values covered by the optical signals &lgr;(t). An evaluation unit receives the determined first &lgr;1(t) and second &lgr;2(t) wavelength values and provides forcorrected wavelength values &lgr;1′(t) based on a comparison of the determined first &lgr;1(t) and second &lgr;2(t) wavelength values.

    摘要翻译: 用于确定多个连续光信号λ(t)的波长的波长确定单元包括用于确定光信号λ(t)的第一波长值λ1(t)的波长计单元。 在已知绝对波长值下具有明确波长特性的绝对测量单元确定了由光信号λ(t)所覆盖的已知绝对波长值的第二波长值λ2(t)。 评估单元接收确定的第一λ1(t)和第二λ2(t)波长值,并且基于确定的第一λ1(t)和第二λ2(t)波长值的比较来提供校正波长值λ1'(t)。