公开(公告)号：US06784325B2

公开(公告)日：2004-08-31

申请号：US09843554

申请日：2001-04-26

申请人： Anantha N. Desikan ,  George E. Whitwell

发明人： Anantha N. Desikan ,  George E. Whitwell

IPC分类号： C07C3906

CPC分类号： C07C37/00 ,  C07C39/06

摘要： The isomerization of an alkylated phenol composition that contains an ortho-alkyl substituted phenol component to isomerize and reduce the level of ortho-alkyl substituted phenol component therein can be accomplished by heating that composition in the presence of a catalytically effective amount of a solid acid catalyst to carry out such isomerization and reduction in the level of ortho-alkyl substituted phenol. Examples of suitable solid acid catalysts can be selected from the H-form zeolites, the supported sulfonic acids, and the heteropoly acids. The resulting isomerized product can be subsequently phosphorylated.

摘要翻译： 含有邻烷基取代的苯酚组分以烷基取代的苯酚组分异构化并降低其中原烷基取代的酚组分的水平的烷基化酚组合物的异构化可以通过在催化有效量的固体酸催化剂 以进行这样的异构化和降低邻烷基取代苯酚的水平。 合适的固体酸催化剂的实例可以选自H型沸石，负载型磺酸和杂多酸。 得到的异构化产物可随后被磷酸化。

公开(公告)号：US06504065B1

公开(公告)日：2003-01-07

申请号：US09676845

申请日：2000-09-29

申请人： William Palmer Enlow ,  Gary Vincent Marlin

发明人： William Palmer Enlow ,  Gary Vincent Marlin

IPC分类号： C07C3906

CPC分类号： C07C37/66 ,  C07C39/235

摘要： Reaction of a phenol with a metal salt of an alcohol produces a metal phenolate salt of a phenol. When a hindered phenol is used a hindered metal phenolate is produced. Such hindered metal phenolate salts are useful in driving the synthesis reaction of hindered phenol esters and phosphite esters to completion.

摘要翻译： 苯酚与醇的金属盐的反应产生苯酚的金属酚盐。 当使用受阻酚时，产生受阻金属酚盐。 这种受阻金属酚盐可用于驱动受阻酚酯和亚磷酸酯的合成反应。

公开(公告)号：US06806395B2

公开(公告)日：2004-10-19

申请号：US10380169

申请日：2003-03-18

申请人： Kimiyuki Shibuya ,  Tadaaki Ohgiya ,  Toru Miura ,  Kazuhiro Onogi

发明人： Kimiyuki Shibuya ,  Tadaaki Ohgiya ,  Toru Miura ,  Kazuhiro Onogi

IPC分类号： C07C3906

CPC分类号： C07C41/30 ,  C07C37/002 ,  C07C37/11 ,  C07C37/50 ,  C07C39/11 ,  C07C43/23 ,  Y02P20/55 ,  C07C39/06

摘要： A process for producing a 3,5-bisalkylphenol (2) according to the following reaction scheme: (wherein R1 represents a hydrogen atom, an alkali metal atom, an alkaline earth metal atom, or a hydroxyl-protecting group (other than methyl group); R2 represents a C1 to C5 lower alkyl group or an optionally substituted phenyl group; and each of R3 and R4, which may be identical to or different from each other, represents a lower alkyl group, an aralkyl group, or an aryl group); a carbinol compound (1); and a process for producing the carbinol compound. The production process of the present invention enables efficient and safe production of a variety of 3,5-bisalkylphenols including 3,5-diisopropylphenol, which are important as synthesis intermediates for drugs and agricultural chemicals, in shorter steps at high purity in high yield, thus contributing to consistent supply of drugs and agricultural chemicals.

摘要翻译： 根据以下反应方案制备3,5-双烷基苯酚（2）的方法：其中R 1表示氢原子，碱金属原子，碱土金属原子或羟基保护基（其他 比甲基）; R 2表示C1〜C5低级烷基或任选取代的苯基; R 3和R 4可以彼此相同或不同，表示 低级烷基，芳烷基或芳基）。 甲醇化合物（1）; 和甲醇化合物的制造方法。 本发明的制造方法能够高效安全地生产各种3,5-二异丙基苯酚，其中3,5-二异丙基苯酚作为药物和农用化学品的合成中间体是重要的，在高纯度，高收率的较短步骤中， 从而有助于持续供应毒品和农药。