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公开(公告)号：US20040254396A1
公开(公告)日：2004-12-16
申请号：US10891155
申请日：2004-07-15
IPC分类号： C07C069/63
CPC分类号： C07C67/14 , C07C45/54 , C07C51/60 , C07C67/287 , C07C67/29 , C07C67/297 , C07C67/307 , C07C59/21 , C07C53/46 , C07C69/63
摘要： A fluorinated polyvalent carbonyl compound is produced by an economically advantageous method from inexpensive materials without requiring a complicated synthetic process step. Namely, the present invention comprises reacting a polyvalent alcohol having at least two kinds of alcohol skeletons selected among a primary alcohol, a secondary alcohol and a tertiary alcohol, with an acid halide to obtain a polyvalent ester compound, fluorinating it in a liquid phase to obtain a perfluorinated polyvalent ester compound, and cleaving the ester bonds derived from primary and secondary alcohols in the perfluoropolyvalent ester compound to obtain a fluorinated polyvalent carbonyl compound.
摘要翻译： 氟化的多价羰基化合物通过经济上有利的方法从便宜的材料制备而不需要复杂的合成工艺步骤。 即，本发明包括使具有选自伯醇，仲醇和叔醇中的至少两种醇骨架的多元醇与酰卤反应，得到多价酯化合物，以液相氟化为 获得全氟化多价酯化合物，并且在全氟聚酯化合物中裂解衍生自伯醇和仲醇的酯键，得到氟化多价羰基化合物。
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公开(公告)号：US20030216595A1
公开(公告)日：2003-11-20
申请号：US10397521
申请日：2003-03-27
发明人： Takashi Okazoe , Kunio Watanabe , Shin Tatematsu , Koichi Yanase , Yasuhiro Suzuki , Daisuke Shirakawa
IPC分类号： C07C069/63
CPC分类号： C07C67/287 , C07C41/06 , C07C51/60 , C07C67/14 , C07C67/297 , C07C53/50 , C07C53/46 , C07C59/135 , C07C69/708 , C07C69/63 , C07C43/178
摘要： The present invention provides a method for producing industrially useful fluorine-containing compounds such as a fluorinated ester compound and an acid fluoride compound. Namely, the present invention resides in a method for producing a fluorinated ester compound, which comprises fluorinating an ester compound which is an ester of a compound having hydroxyl group(s) with a compound having acyl fluoride group(s) and which has a structure which can be fluorinated, in a liquid phase to produce a fluorinated ester compound, wherein the fluorination is carried out in the form of a liquid mixture of the ester compound and the compound having acyl fluoride group(s).
摘要翻译： 本发明提供了一种制造工业上有用的含氟化合物如氟化酯化合物和酰氟化合物的方法。 即，本发明涉及氟化酯化合物的制造方法，其特征在于，将具有羟基的化合物的酯化合物与具有酰氟基的化合物氟化，并且具有结构 其可以在液相中被氟化以产生氟化酯化合物，其中氟化是以酯化合物和具有酰氟基团的化合物的液体混合物的形式进行的。
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3.发明申请Method of synthesizing optically enriched alpha-halo-esters, and product and composition therefrom 失效合成光学富集的α-卤代酯的方法及其产物和组成公开(公告)号：US20030050501A1
公开(公告)日：2003-03-13
申请号：US09861221
申请日：2001-05-18
发明人： Harald Wack
IPC分类号： C07C067/42 , C07C069/63
CPC分类号： C07C67/46 , C07B2200/07 , C07C69/65 , C07C69/712 , C07C69/734 , C07C69/63
摘要： A method of synthesizing highly optically enriched null-halo-esters comprises reacting acid halides with a cinchona alkaloid catalyst and a base to form intermediate ketenes. The ketenes are reacted with electrophilic halogenating reagents to produce null-halo-esters with high enantiomeric excess. The base can be an inorganic salt. The thus-formed null-halo-esters have utility in synthesizing other optically-pure materials.
摘要翻译： 合成高度光学富集的α-卤代酯的方法包括使酰卤与金雀草生物碱催化剂和碱反应以形成中间体烯酮。 烯酮与亲电子卤化试剂反应以产生具有高对映体过量的α-卤代酯。 碱可以是无机盐。 由此形成的α-卤代酯可用于合成其它光学纯的材料。
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公开(公告)号：US20020086884A1
公开(公告)日：2002-07-04
申请号：US09983232
申请日：2001-10-23
发明人： Seth D. Rose , Scott R. Lefler , Steven R. Ottersberg , Ann Y. Kim , Karl J. Okolotowicz , Rosemarie F. Hartman
IPC分类号： A61K031/665 , C07C069/63 , A61K031/4427 , A61K031/4178 , A61K031/336
CPC分类号： A61K31/66 , A61K31/20 , C07C69/63 , C07C217/46 , C07C219/20 , C07D303/32 , C07D303/48 , C07F9/091
摘要： Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, whereby a hydrophobic group (e.g. a farnesyl group) is attached to the protein in the presence of an enzyme (e.g. farnesyl protein transferase). Deactivation of the prenylation enzyme through covalent modification can therefore ultimately result in the mitigation and/or cessation of cancer cell growth. Various prenylation inhibitors having the necessary structural groups to bond covalently, or essentially irreversibly, to the prenylation enzyme include carbonyl or thiocarbonyl compounds (or masked versions of these compounds) and alpha oxo-epoxides bonded to a hydrophobic, substrate-mimicking group. The carbonyl or thiocarbonyl compounds also contain a nucleofugal atom or group to enhance the tendency to form covalent bonds.
摘要翻译： 已知当诸如Ras和RhoB的癌蛋白定位在癌细胞膜的内表面时，诸如Ras和RhoB的癌蛋白以无限制的方式诱导细胞分裂。 定位通过异戊烯化反应进行，由此在酶（例如法呢基蛋白转移酶）的存在下将疏水基团（例如法呢基）连接到蛋白质上。 因此，通过共价修饰来停用异戊烯基化酶可最终导致癌细胞生长的缓解和/或停止。 具有与异戊烯基化酶共价或基本上不可逆地键合的必需结构基团的各种异戊二烯基化抑制剂包括与疏水性底物模拟基团键合的羰基或硫代羰基化合物（或这些化合物的掩蔽型）和α氧代环氧化物。 羰基或硫代羰基化合物还含有核原子或基团以增强形成共价键的倾向。
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5.发明申请公开(公告)号：US20040180954A1
公开(公告)日：2004-09-16
申请号：US10787964
申请日：2004-02-27
IPC分类号： C07C069/63 , A01N043/62 , A01N037/02
CPC分类号： C07C69/63 , C07C2602/42 , Y02P20/55
摘要： A fluorine-containing cyclic ester is represented by the formula 1: 1 wherein each R1 independently represents nullH or nullF, wherein R2 is one selected from the group consisting of nullH, nullF, nullCF3, nullOH, nullCOOH and nullCOOR4, where R4 is an alkyl group having a carbon atom number of 1-15, and wherein R3 is a substituent selected from the group consisting of nullF, nullCF3, and nullR5C(CF3)2OR6, where R5 is one selected from the group consisting of CH2, C2H4, and OCH2, and R6 is H or an acid-labile protecting group.
摘要翻译： 含氟环酯由式1表示：其中每个R 1独立地表示-H或-F，其中R 2是选自-H，-F，-CF 3， - OH，-COOH和-COOR 4，其中R 4是碳原子数为1-15的烷基，其中R 3是选自-F，-CF 3的取代基 ，和-R 5 C（CF 3）2OR 6，其中R 5选自CH 2，C 2 H 4和OCH 2，R 6是H或酸不稳定保护基 。
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公开(公告)号：US20040024243A1
公开(公告)日：2004-02-05
申请号：US10343886
申请日：2003-02-05
IPC分类号： C07C069/63 , C07C053/21
CPC分类号： C08F20/22 , C07C53/21 , C07C67/307 , C07C67/317 , C07C69/63 , C08F220/22 , C07C69/653
摘要： The present invention relates to a fluorination method for the synthesis of halofluoroorganic compounds which can be used, inter alia, as precursors in the synthesis of 2,3-unsaturated fluoroorganic carbonyl compounds comprising a fluorine substituent in the 2 position.
摘要翻译： 本发明涉及用于合成卤代氟有机化合物的氟化方法，其特别可用作合成包含2位氟取代基的2,3-不饱和氟代有机羰基化合物的前体。
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公开(公告)号：US20030166969A1
公开(公告)日：2003-09-04
申请号：US10397230
申请日：2003-03-27
IPC分类号： C07C069/63
CPC分类号： C07C67/14 , C07C45/54 , C07C51/60 , C07C67/287 , C07C67/29 , C07C67/297 , C07C67/307 , C07C59/21 , C07C53/46 , C07C69/63
摘要： A fluorinated polyvalent carbonyl compound is produced by an economically advantageous method from inexpensive materials without requiring a complicated synthetic process step. Namely, the present invention comprises reacting a polyvalent alcohol having at least two kinds of alcohol skeletons selected among a primary alcohol, a secondary alcohol and a tertiary alcohol, with an acid halide to obtain a polyvalent ester compound, fluorinating it in a liquid phase to obtain a perfluorinated polyvalent ester compound, and cleaving the ester bonds derived from primary and secondary alcohols in the perfluoropolyvalent ester compound to obtain a fluorinated polyvalent carbonyl compound.
摘要翻译： 氟化的多价羰基化合物通过经济上有利的方法从便宜的材料制备而不需要复杂的合成工艺步骤。 即，本发明包括使具有选自伯醇，仲醇和叔醇中的至少两种醇骨架的多元醇与酰卤反应，得到多价酯化合物，以液相氟化为 获得全氟化多价酯化合物，并且在全氟聚酯化合物中裂解衍生自伯醇和仲醇的酯键，得到氟化多价羰基化合物。
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公开(公告)号：US20030032836A1
公开(公告)日：2003-02-13
申请号：US10173567
申请日：2002-06-18
申请人： ATOFINA
IPC分类号： C07C069/63 , C07C051/16
摘要： The invention relates to a method for preparing bromodifluoroacetic compounds which comprises converting a 1,1-diflouro-1,2-dibromodihaloethane with oleum having 50-70% SO3 to a bromodifluoroacetyl halide (bromide or chloride) and then in reacting the latter directly with either an alcohol, or with water.
摘要翻译： 本发明涉及一种制备溴二氟乙酸化合物的方法，其包括将具有50-70％SO 3的发烟硫酸的1,1-二溴-1,2,2-二溴二卤代乙烷与溴二氟乙酰卤（溴化物或氯化物）反应，然后将其与 不管是酒精还是用水。
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