公开(公告)号：US20040197357A1

公开(公告)日：2004-10-07

申请号：US10480405

申请日：2004-05-27

Inventor： Alexander Mark Heming ,  Patrick Joseph Mulqueen ,  Herbert Benson Scher ,  Ian Malcolm Shirley

IPC: B01J013/02 ,  A61K007/00

CPC classification number: B01F17/0028 ,  B01F17/005 ,  B01F17/0057 ,  B01F17/0064 ,  B01F17/0071 ,  B01J13/16 ,  Y10S524/916 ,  Y10T428/2985

Abstract: Reactive polymeric surfactants are disclosed, and their use in processes for preparation of microcapsules, and in stabilising emulsions. The surfactants are random graft polymers or block copolymers which contain both hydrophobic and hydrophilic units and in which the hydrophobic unit includes a hydrophilic cross-linking unit which reacts with (a) a wall forming ingredient in a microencapsulation process, or (b) an ingredient in the disperse phase of an emulsion.

Abstract translation: 公开了反应性聚合物表面活性剂，以及它们在制备微胶囊的方法中以及在稳定乳液中的用途。 表面活性剂是含有疏水和亲水单元的无规接枝聚合物或嵌段共聚物，其中疏水单元包括亲水性交联单元，该亲水性交联单元与（a）微胶囊化方法中的壁形成成分反应，或（b）成分 在乳液的分散相中。

公开(公告)号：US20040161470A1

公开(公告)日：2004-08-19

申请号：US10715787

申请日：2003-11-18

Inventor： Alexander Andrianov ,  Bryan Roberts

IPC: A61K009/16 ,  A61K009/50 ,  C12Q001/70 ,  B01J013/02 ,  B01J013/04

CPC classification number: C08J3/24 ,  A61K9/1641 ,  A61K9/1694 ,  A61K9/5146 ,  A61K9/5192 ,  A61K39/39 ,  A61K2039/55555 ,  B01J13/08 ,  B01J13/10 ,  C08G79/025 ,  Y02A50/466

Abstract: Methods of producing polyphosphazene microspheres comprising admixing aqueous solutions of a water-soluble polyphosphazene and an organic amine, or salt thereof, are disclosed.

Abstract translation: 公开了包含水溶性聚磷腈和有机胺或其盐的水溶液混合的聚磷腈微球的制备方法。

公开(公告)号：US20040121002A1

公开(公告)日：2004-06-24

申请号：US10342168

申请日：2003-01-14

Inventor： Phillip K. Lee ,  Paul H. Richardson

IPC: B01J013/02

CPC classification number: A21D8/042 ,  A21D8/047 ,  A23K40/30 ,  A23L33/14 ,  A23P10/35 ,  A23V2002/00 ,  Y10T428/12493 ,  Y10T428/125 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2989 ,  A23V2200/224 ,  A23V2250/192 ,  A23V2250/218

Abstract: The present invention is an encapsulated yeast composite comprising a core comprising yeast and a coating containing an emulsifiable lipid. The yeast includes Saccharomyces cerevisiae. The invention also relates to other encapsulated bioactive substance composites. The nature of the coating provides controlled release of the bioactive substance from the encapsulate. The encapsulated composites are useful in the production of food compositions, food products, and animal feed products.

Abstract translation: 本发明是包含酵母和包含可乳化脂质的包衣的核心的包囊酵母复合物。 酵母包括酿酒酵母（Saccharomyces cerevisiae）。 本发明还涉及其它包封的生物活性物质复合材料。 涂层的性质提供生物活性物质从包封物的控制释放。 包封的复合材料可用于食品组合物，食品和动物饲料产品的生产。

公开(公告)号：US20040070093A1

公开(公告)日：2004-04-15

申请号：US10639770

申请日：2003-08-12

Applicant: Brown University Research Foundation

Inventor： Edith Mathiowitz ,  Donald Chickering III ,  Yong S. Jong ,  Jules S. Jacob

IPC: B01J013/04 ,  B01J013/02

CPC classification number: A61K9/5153 ,  A61K9/1641 ,  A61K9/1694 ,  A61K9/5089 ,  A61K9/5138 ,  A61K9/5146 ,  A61K9/5192 ,  A61K48/00 ,  B01J13/04 ,  B01J13/06

Abstract: A process for preparing nanoparticles and microparticles is provided. The process involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of microparticles.

Abstract translation: 提供了制备纳米颗粒和微粒的方法。 该方法包括形成聚合物和溶剂的混合物，其中溶剂以连续相存在并将混合物引入有效量的非溶剂中以引起微粒的自发形成。

公开(公告)号：US20040058007A1

公开(公告)日：2004-03-25

申请号：US10250868

申请日：2003-07-08

Inventor： Goran Eric Sundholm ,  Mustafa Demirbuker ,  Saeed Moshashaee

IPC: A61K009/16 ,  A61K009/50 ,  B01J013/02 ,  B01J013/04

CPC classification number: A61K38/28 ,  A61K9/1688 ,  A61K31/167 ,  A61K31/575 ,  A61K31/58 ,  B01D11/0411 ,  Y10S977/773 ,  A61K2300/00

Abstract: A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature; and (b) contacting the first liquid with a second liquid comprising a fluid gas and an organic solvent using an anti-solvent fluid gas technique under conditions of temperature and pressure which result in the precipitation of particles comprising the substance, wherein the temperature of the first liquid is at or above the cloud point temperature of the first liquid when the first liquid contacts the second liquid. Also claimed are particles obtained according to the process and compositions containing the particles.

Abstract translation: 一种制备物质如蛋白质或多肽的颗粒的方法，包括：（a）制备包含水，所述物质和调节剂的第一液体，其中所述调节剂在水中具有随温度升高而降低的溶解度; 和（b）使用反溶剂流体气体技术在温度和压力的条件下使第一液体与包含流体气体和有机溶剂的第二液体接触，导致包含物质的颗粒的沉淀，其中 当第一液体接触第二液体时，第一液体处于或高于第一液体的浊点温度。 还要求保护的是根据该方法获得的颗粒和含有颗粒的组合物。

公开(公告)号：US20040032036A1

公开(公告)日：2004-02-19

申请号：US10224441

申请日：2002-08-19

Inventor： Anandaraman Subramaniam ,  Anne Reilly

IPC: B01J013/20 ,  B01J013/02

CPC classification number: A61K8/11 ,  A23L27/72 ,  A23P10/30 ,  A23V2002/00 ,  A61K8/0208 ,  A61K8/922 ,  A61K8/97 ,  A61K2800/412 ,  A61Q19/00 ,  B01J13/10 ,  Y10T428/2984 ,  A23V2200/224 ,  A23V2250/5432 ,  A23V2250/5028

Abstract: The invention relates to a process for preparing microcapsules by coacervation, wherein the cross-linking of a protein is carried out by a plant extract rich in substituted or unsubstituted phenolic compounds.

Abstract translation: 本发明涉及通过凝聚制备微胶囊的方法，其中蛋白质的交联由富含取代或未取代的酚类化合物的植物提取物进行。

公开(公告)号：US20030211035A1

公开(公告)日：2003-11-13

申请号：US10063656

申请日：2002-05-07

Inventor： Patricia Ann Burns ,  Raj D. Patel ,  Hadi Khan Mahabadi ,  Ronald F. Ziolo

IPC: A61K051/00 ,  B01J013/02 ,  A61K038/16 ,  A61K039/395 ,  A61K031/715 ,  A61K009/16 ,  A61K009/50 ,  A61K038/43

CPC classification number: A61K41/009 ,  A61K51/1255 ,  B01J13/02

Abstract: A method of forming polymeric microspheres for biomedical applications includes forming polymeric microspheres by an emulsion/aggregation process from a precursor monomer species, and treating the polymeric microspheres to attach a biomedical functional material to the polymeric microspheres, where the polymeric microspheres have an average particle diameter of from about 1 to about 15 microns with a narrow particle geometric size distribution. The biomedical functional material may be, for example, a radioactive material, a radioactive precursor material, a bioactive agent, or a ligand.

Abstract translation: 形成用于生物医学应用的聚合物微球的方法包括通过来自前体单体种类的乳液/聚集方法形成聚合物微球体，以及处理聚合物微球体将生物医学功能材料附着到聚合物微球体上，其中聚合物微球体具有平均粒径 为约1至约15微米，具有窄的颗粒几何尺寸分布。 生物医学功能材料可以是例如放射性物质，放射性前体材料，生物活性剂或配体。

公开(公告)号：US20030203039A1

公开(公告)日：2003-10-30

申请号：US10435586

申请日：2003-05-12

Applicant: Alkermes Controlled Therapeutics Inc. II

Inventor： Shawn L. Lyons ,  J. Michael Ramstack ,  Steven G. Wright

IPC: A61K009/14 ,  A61K009/16 ,  A61K009/50 ,  B01J013/02 ,  B01J013/04

CPC classification number: A61K9/1647 ,  A61K9/1694 ,  B01J13/02 ,  Y10T428/2982

Abstract: An improved method for preparing microparticles that exhibit controlled release of an effective amount of an active agent over an extended period of time. More particularly, a method is provided for preparing microparticles having a selected release profile for release of active agent contained in the microparticles. By adjusting the degree of drying that is performed during the preparation of the microparticles, the release profile can be controlled. By performing no intermediate drying, an initial burst and a substantially linear release profile is achieved. By performing substantially complete intermediate drying, an initial lag phase and a substantially sigmoidal release profile is achieved.

公开(公告)号：US20030194443A1

公开(公告)日：2003-10-16

申请号：US10191563

申请日：2002-07-10

Inventor： Tetsuya Yano ,  Tsuyoshi Nomoto ,  Shinya Kozaki ,  Tsutomu Honma

IPC: A01N025/28 ,  A61K009/16 ,  A61K009/50 ,  C12P007/62 ,  B01J013/02 ,  B01J013/04

CPC classification number: A61K8/11 ,  A61K8/35 ,  A61K9/5031 ,  A61K47/6925 ,  A61K49/223 ,  A61K2800/412 ,  A61Q17/04 ,  B01J13/04 ,  B01J13/06 ,  B01J13/14 ,  Y02A50/473

Abstract: The invention provides a particulate construct such as microcapsules containing a drug, and serving a slow releasing preparation not associated with a practically unacceptable initial burst release but showing a practically acceptable zero-order release for a certain period and a producing method for such particulate construct, and a slow releasing preparation of a high drug content capable of stably incorporating the drug in the particulate construct such as microcapsules, and a producing method for such preparation. The invention also provides a particulate construct such as microcapsules utilizing a highly functional polymer compound and incorporating oil phase and/or water phase in solid phase, and a producing method therefor. Furthermore, the invention provides a particulate construct such as microcapsules having a hollow structure of a single polymer membrane as the outer shell and capable of containing many bubbles in the fine particles, and a producing method capable of preparing such construct with a high reproducibility. According to the invention, a particulate construct such as microcapsules is formed with polyhydroxyalkanoate of a specified structure and a drug for a desired purpose, an oil phase and/or a water phase, or a gaseous phase is included in such construct.

Abstract translation: 本发明提供了一种颗粒构造物，例如含有药物的微胶囊，并且用于与实际上不可接受的初始爆发释放无关但在一定时间内显示实际上可接受的零级释放的缓释制剂，以及这种颗粒构建体的制备方法， 以及能够稳定地将药物并入微粒构造物如微胶囊中的高药物含量的缓释制剂及其制备方法。 本发明还提供了一种微粒构造物，例如利用高官能度的高分子化合物并将固相中的油相和/或水相并入其中的微胶囊及其制备方法。 此外，本发明提供一种颗粒构造物，例如具有作为外壳的单一聚合物膜的中空结构并且能够在细颗粒中含有许多气泡的微胶囊，以及能够以高再现性制备该构造体的制备方法。 根据本发明，用具有特定结构的聚羟基链烷酸酯和所需目的的药物，油相和/或水相或气相形成微胶囊等颗粒构造物，或者包含气相。

公开(公告)号：US20030180368A1

公开(公告)日：2003-09-25

申请号：US10317547

申请日：2002-12-12

Applicant: Cenes Drug Delivery Limited

Inventor： Gordon Findlay Dawson ,  Frank Koppenhagen

IPC: A61K009/16 ,  B01J013/04 ,  B01J013/02 ,  A61K009/50

CPC classification number: C08J3/14 ,  A61K9/1647 ,  A61K9/1694 ,  C08J3/09

Abstract: A method of forming microparticles (especially including a pharmaceutically active agent) comprising incorporating an emulsifier in an aqueous liquid or in a non-aqueous solution (e.g. of dichloromethane) containing a polymer; forming a dispersion of the aqueous liquid in the non-aqueous solution; and agitating and adding a non-solvent (e.g. silicone oil) for the polymer. The presence of the emulsifier allows microparticle production over a wide range of conditions.

Abstract translation: 一种形成微粒（特别是包括药物活性剂）的方法，包括将乳化剂掺入水性液体或含有聚合物的非水溶液（例如二氯甲烷）中; 在非水溶液中形成水性液体的分散体; 并搅拌并加入聚合物中的非溶剂（例如硅油）。 乳化剂的存在允许在宽范围的条件下生产微粒。