Stabilized pharmaceutical composition
    3.
    发明申请
    Stabilized pharmaceutical composition 失效
    稳定的药物组合物

    公开(公告)号:US20020137771A1

    公开(公告)日:2002-09-26

    申请号:US10079958

    申请日:2002-02-19

    IPC分类号: A61K031/4439 B01J013/00

    摘要: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula 1 wherein R1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R3 and R5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.

    摘要翻译: 本发明的药物组合物包含下式的苯并咪唑化合物其中R 1是氢,烷基,卤素,氰基,羧基,烷氧羰基,烷氧基烷基,氨基甲酰基,氨基甲酰基烷基,羟基,烷氧基,羟基烷基,三氟甲基,酰基,氨基甲酰氧基,硝基, 酰氧基,芳基,芳氧基,烷硫基或烷基亚磺酰基,R2是氢,烷基,酰基,烷酰氧基,氨基甲酰基,烷基氨基甲酰基,二烷基氨基甲酰基,烷基羰基甲基,烷氧基羰基甲基或烷基磺酰基,R3和R5相同或不同,各自为氢,烷基,烷氧基或烷氧基烷氧基 ,R4为氢,烷基,可任选氟化的烷氧基或烷氧基烷氧基,m为0〜4的整数,碱性无机盐稳定剂为物理上稳定的。 镁和钙碱性无机盐稳定剂是特别有用的。

    Method and microcapsule compound waterborne polyurethane
    4.
    发明申请
    Method and microcapsule compound waterborne polyurethane 审中-公开
    方法和微胶囊复合水性聚氨酯

    公开(公告)号:US20040044128A1

    公开(公告)日:2004-03-04

    申请号:US10230983

    申请日:2002-08-30

    IPC分类号: B01J013/00

    摘要: The present invention provides a method and microcapsule compound waterborne polyurethane wherein further comprises forming homogeneous dispersive liquid from the compound process of waterborne polyurethane prepolymer added water solution of microcapsules with waterborne polyurethane shell for the phase change material and the present invention of the method further adds curing agent, antifoam and thickener for coating fabrics.

    摘要翻译: 本发明提供了一种方法和微胶囊化合物水性聚氨酯,其中还包括由水性聚氨酯预聚物加水微胶囊水溶液与水性聚氨酯外壳的相变材料形成均相分散液,本发明方法进一步添加固化 代理,消泡剂和增稠剂。

    Aqueous rare earth phosphate collidal dispersion and preparation method
    5.
    发明申请
    Aqueous rare earth phosphate collidal dispersion and preparation method 审中-公开
    含水稀土磷酸盐碰撞分散体及其制备方法

    公开(公告)号:US20040044088A1

    公开(公告)日:2004-03-04

    申请号:US10433762

    申请日:2003-09-22

    IPC分类号: B01J013/00

    CPC分类号: B01J13/0013

    摘要: The invention concerns an aqueous colloidal dispersion of isotropic particles of a phosphate of at least one rare earth and is characterized in that it comprises either a complexing agent with a pK (cologarithm of the dissociation constant of the complex formed by the complexing agent and said rare earth) of more than 2.5; or an anion of a monobasic acid, soluble in water and with a pKa in the range 2.5 to 5; or said complexing agent and/or said anion of a monobasic acid. In the case of cerium and lanthanum, the mean particle size is at most 20 nm. The dispersions can have a degree of colloid agglomeration of less than 40%.This dispersion can be prepared by forming an aqueous mixture comprising at least one rare earth salt and the complexing agent or monobasic acid anion; by adding a base then phosphate ions to the mixture formed; and heating the mixture obtained. A precipitate is obtained that is re-dispersed in water.

    摘要翻译: 本发明涉及至少一种稀土磷酸盐的各向同性粒子的水性胶体分散体,其特征在于它包括与pK络合剂的络合剂(由络合剂形成的络合物的解离常数和所述稀土 地球)超过2.5; 或一元酸的阴离子,可溶于水和pKa在2.5至5的范围内; 或所述络合剂和/或一元酸的所述阴离子。 在铈和镧的情况下,平均粒径为20nm以下。 分散体可以具有小于40%的胶体聚集度。该分散体可以通过形成包含至少一种稀土盐和络合剂或一元酸阴离子的含水混合物来制备; 通过向形成的混合物中加入碱,然后加入磷酸根离子; 并加热获得的混合物。 得到重新分散在水中的沉淀物。

    COATED POWDER AND COSMETIC PREPARED BY BLENDING THE SAME
    6.
    发明申请
    COATED POWDER AND COSMETIC PREPARED BY BLENDING THE SAME 失效
    涂层粉末和化妆品通过混合制成

    公开(公告)号:US20030035883A1

    公开(公告)日:2003-02-20

    申请号:US09147861

    申请日:1999-03-17

    IPC分类号: A61K007/021 B01J013/00

    摘要: Coated powder is obtained by applying a material having a refractive index of 1.9 to 3.1 to powder having a refractive index of 1.3 to 1.8 as a core and further applying a material having a refractive index of 1.3 to 1.8 to the coated core. When this powder is used for cosmetics or paints, natural coloring can be accomplished without deteriorating lightness because a screening effect is not high.

    摘要翻译: 通过对折射率为1.3〜1.8的粉末作为芯,对折射率为1.3〜1.8的材料涂布折射率为1.9〜3.1的材料,进一步将涂布的芯的折射率为1.3〜1.8的材料进行涂布。 当这种粉末用于化妆品或油漆时,由于筛选效果不高,可以实现天然着色而不劣化亮度。

    Coated dibasic calcium phosphate
    7.
    发明申请
    Coated dibasic calcium phosphate 审中-公开
    涂复磷酸氢钙

    公开(公告)号:US20040091544A1

    公开(公告)日:2004-05-13

    申请号:US10643319

    申请日:2003-08-19

    摘要: An oral formulation containing an active pharmaceutical ingredient, for instance a peptide pharmaceutical, such as insulin, coated onto a suitable particulate substrate, such as dibasic calcium phosphate. The oral formulation may be a modified release formulation, for instance a controlled release formulation or a sustained release formulation, or may be an immediate release formulation. Also, the formulation may be encapsulated in gelatin capsules or may be compressed into tablets.

    摘要翻译: 含有活性药物成分,例如肽药物如胰岛素的口服制剂,其涂覆在合适的颗粒基质上,例如磷酸氢钙。 口服制剂可以是调制释放制剂,例如控释制剂或持续释放制剂,或可以是立即释放制剂。 此外,制剂可以包封在明胶胶囊中,或者可以压制成片剂。

    Process
    8.
    发明申请
    Process 失效
    处理

    公开(公告)号:US20040062806A1

    公开(公告)日:2004-04-01

    申请号:US10416116

    申请日:2003-11-06

    摘要: The present invention relates to a process using ultrasonic cutting for the preparation of an oral delivery device comprising a core which includes a pharmaceutically active agent covered by an outer coating which includes one or more openings communicating from the exterior of the device toward the core.

    摘要翻译: 本发明涉及一种使用超声波切割来制备口服递送装置的方法,所述口腔递送装置包括芯,所述芯包括由外部涂层覆盖的药物活性剂,所述外部涂层包括从所述装置的外部朝向芯部连通的一个或多个开口。

    Microcapsule composition for electrophoretic displays
    9.
    发明申请
    Microcapsule composition for electrophoretic displays 审中-公开
    电泳显微镜用微胶囊组合物

    公开(公告)号:US20040012106A1

    公开(公告)日:2004-01-22

    申请号:US10611934

    申请日:2003-07-03

    IPC分类号: B01J013/00

    摘要: The present invention provides: a microcapsule composition for electrophoretic displays; a production process for the microcapsule composition for the electrophoretic displays; a production process for a sheet for the electrophoretic displays; and a handling method for microcapsules for the electrophoretic displays; wherein the microcapsule composition contains microcapsules and, when used for the electrophoretic displays, can make them as excellent as conventional in various performances (e.g. longtime stability of displaying, respondability of displaying, contrast, and number of times of display rewritability) and, particularly above all, can make the electrophoretic displays exhibit a very high performance as to the contrast. The present invention composition is a composition used for preparation of a coating liquid and comprises an aqueous medium and microcapsules for the electrophoretic displays, wherein the microcapsules include a shell and a dispersion that is capsuled in the shell, wherein the dispersion includes a solvent and electrophoretic fine particles that are dispersed in the solvent; with the composition being characterized by: being a product as obtained without involving the step of drying the microcapsules; and having a microcapsule content of 30 to 80 weight %.

    摘要翻译: 本发明提供一种电泳显微镜用微胶囊组合物, 用于电泳显示器的微胶囊组合物的制备方法; 用于电泳显示器的片材的生产方法; 以及用于电泳显示器的微胶囊的处理方法; 其中微胶囊组合物含有微胶囊,并且当用于电泳显示器时,可以使它们在各种性能(例如,显示的长时间稳定性,显示的可反应性,对比度和显示重写次数)方面优异,并且特别地在 所有这些都可以使电泳显示器具有非常高的对比度的性能。 本发明组合物是用于制备涂布液的组合物,其包含用于电泳显示器的水性介质和微胶囊,其中所述微胶囊包括壳和在壳中被包封的分散体,其中所述分散体包括溶剂和电泳 分散在溶剂中的细颗粒; 该组合物的特征在于:作为获得的产物,而不涉及干燥微胶囊的步骤; 微胶囊含量为30〜80重量%。