公开(公告)号：US06487442B1

公开(公告)日：2002-11-26

申请号：US09559653

申请日：2000-04-28

Applicant: Nicholas Wood

Inventor： Nicholas Wood

IPC: A61B50468

CPC classification number: A61B5/0468 ,  A61B5/0022 ,  A61B5/4035

Abstract: An apparatus and method for predicting potentially fatal arrhythmias up to twenty four hours in advance of the event by employing formulas indicating either too little or too much heart rate variability. A number of these formulas have both predetermined upper and lower limits, which if exceeded for a period of time are a predictor of a potentially fatal arrhythmia. When a patient's ALARM condition is predicted, whether the patient is indoors or outdoors, conscious or unconscious, a redundant protocol is utilized to relay that ALARM condition to a central monitoring station. The central monitoring station informs the patient's doctor, and then uses what ever means are available to transport the patient to the nearest emergency room for treatment. An apparatus and method for pacing the heart in a natural way, once a potentially fatal arrhythmia has been predicted is also disclosed.

Abstract translation: 一种用于通过使用指示太小或太多心率变异性的公式来预测事件之前多达二十四小时的潜在致命性心律失常的装置和方法。 这些公式中的一些具有预定的上限和下限，如果超过一段时间是潜在的致命性心律失常的预测因子。 当患者的ALARM状况被预测时，患者是否在室内或室外，有意识或无意识的情况下，使用冗余协议将该ALARM状况中继到中央监测站。 中央监测站通知患者的医生，然后使用可用的方法将患者运送到最近的急诊室进行治疗。 还公开了一种预测可能致命的心律失常的自然起搏心脏的装置和方法。

公开(公告)号：US06687535B2

公开(公告)日：2004-02-03

申请号：US09792302

申请日：2001-02-23

Applicant: Arto Hautala ,  Ilkka Heikkilä ,  Timo Mäkikallio ,  Seppo Nissilä ,  Mikko Tulppo

Inventor： Arto Hautala ,  Ilkka Heikkilä ,  Timo Mäkikallio ,  Seppo Nissilä ,  Mikko Tulppo

IPC: A61B50468

CPC classification number: A61B5/222 ,  A61B5/0002 ,  A61B5/024

Abstract: A heart rate measuring arrangement for controlling a recovery exercise of a person from a fitness exercise which measures the heart rate, forms control information, and displays the formed control information so that the recovery exercise is performed at a controlled heart rate level.

Abstract translation: 一种心率测量装置，用于控制来自测量心率的健身运动中的人的恢复运动，形成控制信息，并且显示所形成的控制信息，使得以受控心率水平执行恢复运动。

公开(公告)号：US06272377B1

公开(公告)日：2001-08-07

申请号：US09411345

申请日：1999-10-01

Applicant: Robert J. Sweeney ,  Bruce H. KenKnight

Inventor： Robert J. Sweeney ,  Bruce H. KenKnight

IPC: A61B50468

CPC classification number: A61N1/3622 ,  G06F19/00 ,  G16H50/30

Abstract: A cardiac rhythm management system predicts when an arrhythmia will occur and in one embodiment invokes a therapy to prevent or reduce the consequences of the arrhythmia. A cardiac arrhythmia trigger/marker is detected from a patient, and based on the trigger/marker, the system estimates a probability of a cardiac arrhythmia occurring during a predetermined future time interval. The system provides a list of triggers/markers, for which detection values are recurrently obtained at various predetermined time intervals. Based on detection values and conditional probabilities associated with the triggers/markers, a probability estimate of a future arrhythmia is computed. An arrhythmia prevention therapy is selected and activated based on the probability estimate of the future arrhythmia.

Abstract translation: 心律管理系统预测何时发生心律失常，并且在一个实施例中调用治疗以预防或减少心律失常的后果。 从患者检测到心律失常触发/标记，并且基于触发/标记，系统估计在预定的未来时间间隔期间发生心律失常的概率。 该系统提供了一个触发/标记列表，为各种预定时间间隔循环获得检测值。 基于与触发/标记相关联的检测值和条件概率，计算未来心律失常的概率估计。 基于对未来心律失常的概率估计，选择并激活心律失常预防疗法。

公开(公告)号：US06731974B2

公开(公告)日：2004-05-04

申请号：US09760594

申请日：2001-01-16

Applicant: Jacob Levitan ,  Meir Lewkowicz

Inventor： Jacob Levitan ,  Meir Lewkowicz

IPC: A61B50468

CPC classification number: A61B5/0245

Abstract: A system for measuring heart rate variability (HRV) of a patent comprises: recording means for obtaining and regulating heartbeat-to-heartbeat intervals for a predetermined period of time; processing means for digitizing said intervals, forming a recurrence plot, and assigning a unit mass to each point on the plot representing a measured interval, and calculating the determinant by the expression Qdet=QxxQyy wherein: Qxx is the quadrupole moment relative to the X axis of the principal coordinate, Qyy is the quadrupole moment relative to the Y axis of the principal coordinate; and Qdet is the product of Qxx and Qyy.

Abstract translation: 用于测量专利的心率变异性（HRV）的系统包括：用于在预定时间段内获得和调节心跳到心跳间隔的记录装置;用于数字化所述间隔的处理装置，形成复发图并分配单位 质量到绘图上的每个点，表示测量的间隔，并且通过表达式计算行列式，其中：Qxx是相对于主坐标的X轴的四极矩，Qyy是相对于主坐标的Y轴的四极矩; QDet是Qxx和Qyy的产品。

公开(公告)号：US06490479B2

公开(公告)日：2002-12-03

申请号：US09750846

申请日：2000-12-28

Applicant: Elizabeth Anne Bock

Inventor： Elizabeth Anne Bock

IPC: A61B50468

CPC classification number: A61B5/02405 ,  A61B5/046 ,  A61B5/7264

Abstract: A method and apparatus to detect irregular heart activity based upon a ventricular activity analysis, P wave activity, similarities in R wave to R wave intervals, and a state evaluation. The invention includes a beat classification module that receives ECG information as an input. The beat classification module determines whether the heart beat being analyzed falls within classifications that are suitable for use in analyzing whether an irregular condition exists. If the beat falls within a class suitable for analysis, the ECG information is fed to an interval calculator. The interval calculator determines the interval between successive R waves. The information from the interval calculator is provided to a probability engine and to a contextual analysis module. The probability engine is designed to detect atrial fibrillation based upon beat classification and RR interval values from the interval calculator. The probability engine outputs a state variable that indicates a probability of whether an irregular condition is present. The contextual analysis module matches predefined maps to a running map of the current ECG information. The contextual analysis module also determines the similarity between consecutive RR intervals and checks for sequences of matching classes. ECG information is also supplied to a P wave detection module to detect the presence of P waves. Information from the probability analysis engine, the contextual analysis module, and the P wave detection module is then provided to a state evaluation module. The state evaluation module uses the outputs of the three modules to determine whether an irregular condition exists.

公开(公告)号：US06240313B1

公开(公告)日：2001-05-29

申请号：US09294725

申请日：1999-04-19

Applicant: James A. Esler

Inventor： James A. Esler

IPC: A61B50468

CPC classification number: A61N1/3627 ,  A61N1/368

Abstract: A cardiac rhythm management system recognizes patterns of interval durations, distinguishing between events in different heart chambers even though signals associated with those different heart chambers are processed using a commonly shared sensing circuit. A therapy delivery algorithm ignores intervals between cardiac events occurring in different heart chambers when determining a cardiac rate upon which the delivery of therapy is based. This reduces the risk of inappropriate delivery of therapy to the patient. Delayed conduction left ventricular beats are not erroneously recognized as a subsequent right ventricular beat, preventing such short intervals from inappropriately triggering a defibrillation countershock. The system detects cardiac events, obtains a current interval between a current cardiac event and a previous cardiac event, and classifies the current interval into at least first and second categories, based on a duration of the current interval. The system determines timing of delivery of output energy based on whether a previous interval is in the first category and the current interval is in the second category. The system then stores the current interval as the previous interval.

公开(公告)号：US06508771B1

公开(公告)日：2003-01-21

申请号：US09452533

申请日：1999-12-01

Applicant: Vasant Padmanabhan ,  Walter H. Olson

Inventor： Vasant Padmanabhan ,  Walter H. Olson

IPC: A61B50468

CPC classification number: A61N1/3702 ,  A61N1/3925

Abstract: An implantable monitoring device for monitoring a patient's heart rate variability over time. The device includes a cardiac electrogram amplifier, a sensing electrode coupled to an input of the amplifier, timing circuitry, processing circutry and a memory. The timing circuitry defines successive monitoring periods each extending over a period of hours, the monitoring periods together extending at least over a period of weeks and also defines successive shorter time periods during each monitoring period. The memory stores heart intervals between depolarizations of the patient's heart sensed by the amplifier during the shorter time periods. The processing circuitry calculates median intervals between depolarizations of the patient's heart sensed by the amplifier during the shorter time periods and calculates standard deviations of the median intervals calculated during each monitoring period. The processing circuitry may also reject heart intervals occurring during tachyarrhythmias and calculate median intervals based only on heart intervals not rejected.

Abstract translation: 一种可植入监测装置，用于随时间监测患者的心率变异性。 该装置包括心电图放大器，耦合到放大器的输入的感测电极，定时电路，处理循环和存储器。 定时电路定义了连续的监视周期，每个监视周期都在几个小时内延伸，监视周期至少延长了几周，并且还在每个监视周期内定义了连续较短的时间段。 存储器存储在较短时间段期间由放大器感测的患者心脏的去极化之间的心脏间隔。 处理电路计算在较短时间段期间由放大器感测到的患者心脏的去极化之间的中间间隔，并计算在每个监测期间计算的中位数间隔的标准偏差。 处理电路还可以排除在快速性心律失常期间发生的心脏间隔，并且仅基于未被拒绝的心脏间隔计算中位数间隔。

公开(公告)号：US06330469B1

公开(公告)日：2001-12-11

申请号：US09668309

申请日：2000-09-25

Applicant: M. Pamela Griffin ,  J. Randall Moorman

Inventor： M. Pamela Griffin ,  J. Randall Moorman

IPC: A61B50468

CPC classification number: A61B5/0444 ,  A61B5/02405 ,  A61B5/02411 ,  A61B5/412 ,  A61B5/4362 ,  G06F19/00 ,  G06F19/3456 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  G16H50/50

Abstract: In one aspect of the invention, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a premature newborn infant. The method comprises: (a) continuously monitoring heart rate variability in the premature newborn infant; and (b) identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness. This method can be use to diagnose illnesses such as, but not limited to, sepsis, necrotizing enterocolitis, pneumonia and meningitis. In another aspect, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a patient. The method comprises: (a) continuously monitoring the patient's RR intervals; (b) generating a normalized data set of the RR intervals; (c) calculating one or more of (i) moments of the data set selected from the third and higher moments and (ii) percentile values of the data set; and (d) identifying an abnormal heart rate variability associated with the illness based on one or more of the moments and the percentile values.

Abstract translation: 在本发明的一个方面，提供了一种用于在早产新生儿中早期发现亚急性，潜在的灾难性感染性疾病的方法和装置。 该方法包括：（a）连续监测早产新生儿心率变异性; 和（b）确定与疾病相关的心率变异性中的至少一种特征异常。 该方法可用于诊断疾病，例如但不限于败血症，坏死性小肠结肠炎，肺炎和脑膜炎。 另一方面，提供了一种用于在患者中早期检测亚急性潜在的灾难性感染性疾病的方法和装置。 该方法包括：（a）持续监测患者的RR间期; （b）生成RR间隔的归一化数据集; （c）计算（i）从第三和更高时刻选择的数据集的时刻和（ii）数据集的百分位数值中的一个或多个; 和（d）基于一个或多个时刻和百分位数值来识别与疾病相关的异常心率变异性。

公开(公告)号：US06216032B1

公开(公告)日：2001-04-10

申请号：US09271279

申请日：1999-03-17

Applicant: M. Pamela Griffin ,  J. Randall Moorman

Inventor： M. Pamela Griffin ,  J. Randall Moorman

IPC: A61B50468

CPC classification number: A61B5/0444 ,  A61B5/02405 ,  A61B5/02411 ,  A61B5/412 ,  A61B5/4362 ,  G06F19/00 ,  G06F19/3456 ,  G16H10/40 ,  G16H15/00 ,  G16H50/20 ,  G16H50/50

Abstract: In one aspect, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a premature newborn infant. The method comprises: (a) continuously monitoring heart rate variability in the premature newborn infant; and (b) identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness. This method can be use to diagnose illnesses such as, but not limited to, sepsis, necrotizing enterocolitis, pneumonia and meningitis. In another aspect, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a patient. The method comprises: (a) continuously monitoring the patient's RR intervals; (b) generating a normalized data set of the RR intervals; (c) calculating one or more of (i) moments of the data set selected from the third and higher moments and (ii) percentile values of the data set; and (d) identifying an abnormal heart rate variability associated with the illness based on one or more of the moments and the percentile values.

Abstract translation: 在一方面，提供了一种用于在早产新生儿中早期发现亚急性潜在的潜在感染性疾病的方法和装置。 该方法包括：（a）连续监测早产新生儿心率变异性; 和（b）确定与疾病相关的心率变异性中的至少一种特征异常。 该方法可用于诊断疾病，例如但不限于败血症，坏死性小肠结肠炎，肺炎和脑膜炎。 另一方面，提供了一种用于在患者中早期检测亚急性潜在的灾难性感染性疾病的方法和装置。 该方法包括：（a）持续监测患者的RR间期; （b）生成RR间隔的归一化数据集; （c）计算（i）从第三和更高时刻选择的数据集的时刻和（ii）数据集的百分位数值中的一个或多个; 和（d）基于一个或多个时刻和百分位数值来识别与疾病相关的异常心率变异性。

公开(公告)号：US06636762B2

公开(公告)日：2003-10-21

申请号：US09843917

申请日：2001-04-30

Applicant: Malcolm J. Begemann

Inventor： Malcolm J. Begemann

IPC: A61B50468

CPC classification number: A61N1/3622 ,  A61B5/02405 ,  A61B5/0245 ,  A61N1/3627

Abstract: A method of monitoring heart failure is provided. A baseline heart rate change value is determined, wherein the baseline heart rate change value comprises a speed at which a first initial heart rate changes to a second initial heart rate. At least one subsequent heart rate change value is also determined, wherein the subsequent heart rate change value comprises a subsequent speed at which a first subsequent heart rate changes to a second subsequent heart rate. The subsequent heart rate change value is compared to the baseline heart rate change value to obtain at least one heart failure value. Systems and programs for using the method are also provided.