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公开(公告)号：US07927610B2
公开(公告)日：2011-04-19
申请号：US11929022
申请日：2007-10-30
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
摘要翻译： 公开了用于诊断结核病或诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的分枝杆菌感染。 还提供了针对这种多肽的抗体。 此外，这些化合物可以配制成针对分枝杆菌感染免疫的疫苗和/或药物组合物。
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公开(公告)号：US07927611B2
公开(公告)日：2011-04-19
申请号：US11929064
申请日：2007-10-30
CPC分类号： C07K14/35 , A61K38/00 , A61K39/04 , A61K48/00 , A61K2039/53 , A61K2039/55566 , C07K2319/00 , C12Q1/6883 , C12Q1/689 , C12Q2600/158 , G01N33/5695 , G01N2469/20
摘要： Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
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