公开(公告)号：US20180246081A1

公开(公告)日：2018-08-30

申请号：US15964210

申请日：2018-04-27

申请人： SANTEN PHARMACEUTICAL CO., LTD.

发明人： Hideki MIYAKE ,  Tomoko ODA

IPC分类号： G01N33/50 ,  A61K31/7052 ,  A01K67/027 ,  A61K45/00

CPC分类号： G01N33/5088 ,  A01K67/027 ,  A01K2207/25 ,  A01K2227/105 ,  A01K2267/035 ,  A61K31/7052 ,  A61K45/00 ,  G01N33/5082 ,  G01N2500/10 ,  G01N2800/162

摘要： A method for changing a condition of an eyelid of a hairless animal, a model animal for evaluating a therapeutic or prophylactic effect against an eyelid disease obtained by the method, a method for producing the model animal, a method of screening using the model animal and a substance having a therapeutic or prophylactic effect against an eyelid disease selected by the method of screening, and a therapeutic or prophylactic agent against an eyelid disease containing the substance as an active ingredient.

公开(公告)号：US20170322226A1

公开(公告)日：2017-11-09

申请号：US15611016

申请日：2017-06-01

申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION

发明人： Gordon W. LAURIE

IPC分类号： G01N33/68 ,  G01N33/573 ,  A61K9/00 ,  A61K38/17

CPC分类号： G01N33/6893 ,  A61K9/0048 ,  A61K38/1709 ,  A61K38/18 ,  C07K14/475 ,  C12Y302/01166 ,  G01N33/573 ,  G01N33/68 ,  G01N2333/4706 ,  G01N2333/4722 ,  G01N2333/4728 ,  G01N2333/70596 ,  G01N2333/924 ,  G01N2800/16 ,  G01N2800/162

摘要： The present invention provides compositions and methods for identifying subjects suffering from dry eye that can be treated by topical administration of a composition comprising lacritin or a bioactive fragment thereof. The application discloses in part that a ˜90 KDa deglycanated form of syndecan-1 is abundant in tears of normal individuals but not individuals suffering from dry eye, whereas a ˜25 kDa syndecan-1 fragment is detectable in dry, but not normal tears.

公开(公告)号：US09217702B2

公开(公告)日：2015-12-22

申请号：US13299197

申请日：2011-11-17

申请人： Benjamin Sullivan

发明人： Benjamin Sullivan

IPC分类号： G01N33/48 ,  G01N13/04 ,  G01N27/26 ,  G06F19/24

CPC分类号： G01N13/04 ,  B01L3/502715 ,  B01L2300/0654 ,  G01N21/6486 ,  G01N27/07 ,  G01N27/26 ,  G01N33/487 ,  G01N2800/162 ,  G01N2800/24 ,  G06F19/24

摘要： A fluid sample is measured with a tear film measuring system that includes a processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device configured to perform analyzes of osmolarity and of one or more biomarkers within the sample fluid, wherein the analysis of biomarkers includes normalization of biomarker concentration values.

摘要翻译： 用泪液测量系统测量流体样品，所述泪液膜测量系统包括处理装置，所述处理装置接收包含被配置为容纳等分试样体积的样品流体的样品区域的样品芯片，所述处理装置被配置为进行渗透压的分析和一种或多种生物标志物 在样品流体中，其中生物标志物的分析包括生物标志物浓度值的归一化。

公开(公告)号：US20240230669A1

公开(公告)日：2024-07-11

申请号：US18390883

申请日：2023-12-20

申请人： University of Virginia Patent Foundation

发明人： Gordon W. Laurie

IPC分类号： G01N33/68 ,  A61K9/00 ,  A61K38/17 ,  A61K38/18 ,  C07K14/475 ,  G01N33/573

CPC分类号： G01N33/6893 ,  A61K9/0048 ,  A61K38/1709 ,  A61K38/18 ,  C07K14/475 ,  C12Y302/01166 ,  G01N33/573 ,  G01N33/68 ,  G01N2333/4706 ,  G01N2333/4722 ,  G01N2333/4728 ,  G01N2333/70596 ,  G01N2333/924 ,  G01N2800/16 ,  G01N2800/162

摘要： The present invention provides compositions and methods for identifying subjects suffering from dry eye that can be treated by topical administration of a composition comprising lacritin or a bioactive fragment thereof. The application discloses in part that a ˜90 KDa deglycanated form of syndecan-1 is abundant in tears of normal individuals but not individuals suffering from dry eye, whereas a ˜25 kDa syndecan-1 fragment is detectable in dry, but not normal tears.

公开(公告)号：US20150011475A1

公开(公告)日：2015-01-08

申请号：US14495933

申请日：2014-09-25

申请人： R-TECH UENO, LTD.

发明人： Yukihiko MASHIMA ,  Akio SIRANITA

IPC分类号： A61K49/00 ,  A61K9/00 ,  A61K38/38

CPC分类号： A61K49/0008 ,  A61K9/0048 ,  A61K38/00 ,  A61K38/38 ,  A61K38/385 ,  A61K47/50 ,  G01N33/5088 ,  G01N2800/16 ,  G01N2800/162

摘要： The present invention provides a method for screening an agent being useful for the treatment of dry eye and/or corneal and conjunctival lesion of dry eye severity level 3 or more according to the report of the International Dry Eye WorkShop (DEWS Report) (2007) and a pharmaceutical composition comprising the agent. The present invention further provides a method for the treatment of dry eye and/or corneal and conjunctival lesion of dry eye severity level 3 or more according to DEWS Report (2007) using the agent.

摘要翻译： 本发明提供了根据国际干眼工作室（DEWS Report）（2007）的报告，筛选可用于治疗干眼症严重程度3级以上的干眼症和/或角膜和结膜病变的药剂的方法， 以及包含该药剂的药物组合物。 本发明还提供了根据DEWS报告（2007）使用该试剂治疗干眼症和/或干眼症严重程度级别3以上的角膜和结膜损伤的方法。

公开(公告)号：US08871995B2

公开(公告)日：2014-10-28

申请号：US13512112

申请日：2010-11-26

申请人： Yukihiko Mashima ,  Akio Siranita

发明人： Yukihiko Mashima ,  Akio Siranita

IPC分类号： G01N33/00 ,  A01K67/00 ,  A01K67/027 ,  A01K67/033 ,  A61K49/00 ,  A61K38/00 ,  G01N33/50 ,  A61K38/38

CPC分类号： A61K49/0008 ,  A61K9/0048 ,  A61K38/00 ,  A61K38/38 ,  A61K38/385 ,  A61K47/50 ,  G01N33/5088 ,  G01N2800/16 ,  G01N2800/162

摘要： The present invention provides a method for screening an agent being useful for the treatment of dry eye and/or corneal and conjunctival lesion of dry eye severity level 3 or more according to the report of the International Dry Eye WorkShop (DEWS Report) (2007) and a pharmaceutical composition comprising the agent. The present invention further provides a method for the treatment of dry eye and/or corneal and conjunctival lesion of dry eye severity level 3 or more according to DEWS Report (2007) using the agent.

摘要翻译： 本发明提供了根据国际干眼工作室（DEWS Report）（2007）的报告，筛选可用于治疗干眼症严重程度3级以上的干眼症和/或角膜和结膜病变的药剂的方法， 和包含该试剂的药物组合物。 本发明还提供了根据DEWS报告（2007）使用该试剂治疗干眼症和/或干眼症严重程度级别3以上的角膜和结膜损伤的方法。

公开(公告)号：US08409565B2

公开(公告)日：2013-04-02

申请号：US11705829

申请日：2007-02-14

申请人： Francesca Levi-Schaffer ,  Ido Bachelet ,  Ariel Munitz ,  Marc E. Rothenberg

发明人： Francesca Levi-Schaffer ,  Ido Bachelet ,  Ariel Munitz ,  Marc E. Rothenberg

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K39/395

CPC分类号： C07K16/2806 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/76 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/6893 ,  G01N2800/065 ,  G01N2800/122 ,  G01N2800/14 ,  G01N2800/162 ,  G01N2800/202 ,  G01N2800/24

摘要： CD48, a surface-marker molecule present in eosinophils, is disclosed herein as a key molecule in allergic conditions, particularly in allergic airway inflammations like asthma, allergy and nasal polyposis. CD48 is thus presented as a target molecule in the treatment of said conditions. In addition, diagnostic methods, and a kit for the diagnosis of allergic inflammatory conditions are described, based on the detection of CD48 expression.

摘要翻译： 存在于嗜酸性粒细胞中的表面标记分子CD48在本文中被公开为过敏性疾病中的关键分子，特别是在哮喘，过敏和鼻息肉病等过敏性气道炎症中。 因此，在所述条件的治疗中CD48作为靶分子呈现。 此外，基于CD48表达的检测，描述了诊断方法和用于诊断过敏性炎症病症的试剂盒。

公开(公告)号：US08541000B2

公开(公告)日：2013-09-24

申请号：US13142914

申请日：2008-12-30

申请人： Kaw Yan Chua ,  Keh-Liang Lin ,  I-Chun Kuo ,  Chiung-Hui Huang

发明人： Kaw Yan Chua ,  Keh-Liang Lin ,  I-Chun Kuo ,  Chiung-Hui Huang

IPC分类号： A61K39/00 ,  A61K39/35 ,  A61K39/36 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

CPC分类号： G01N33/6854 ,  A61K39/00 ,  C07K14/43531 ,  G01N2333/43513 ,  G01N2800/122 ,  G01N2800/162 ,  G01N2800/202

摘要： The present invention relates to a new variant of the group 2 allergen from the house dust mite Dermatophagoides pteronyssinus, named Der p 2 variant, and uses thereof. The new variant exhibits cDNA and protein sequence diversity from other known Der p 2 variants.

摘要翻译： 本发明涉及来自房屋尘螨Dermatophagoides pteronyssinus的2组变应原的新变体，命名为Der p2变体及其用途。 新的变体表现出来自其他已知Der p2变体的cDNA和蛋白质序列多样性。

公开(公告)号：US20130177575A1

公开(公告)日：2013-07-11

申请号：US13780994

申请日：2013-02-28

申请人： Yissum Research Developmnet Company of the Hebrew University of Jerusalem Ltd.

发明人： Francesca LEVI-SCHAFFER ,  Ido BACHELET ,  Ariel MUNITZ ,  Marc E. ROTHENBERG

IPC分类号： G01N33/68

CPC分类号： C07K16/2806 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/76 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/6893 ,  G01N2800/065 ,  G01N2800/122 ,  G01N2800/14 ,  G01N2800/162 ,  G01N2800/202 ,  G01N2800/24

摘要： CD48, a surface-marker molecule present in eosinophils, is disclosed herein as a key molecule in allergic conditions, particularly in allergic airway inflammations like asthma, allergy and nasal polyposis. CD48 is thus presented as a target molecule in the treatment of said conditions. In addition, diagnostic methods, and a kit for the diagnosis of allergic inflammatory conditions are described, based on the detection of CD48 expression.

公开(公告)号：US20110144919A1

公开(公告)日：2011-06-16

申请号：US13031051

申请日：2011-02-18

申请人： Benjamin Sullivan

发明人： Benjamin Sullivan

IPC分类号： G01N33/48

CPC分类号： G01N13/04 ,  B01L3/502715 ,  B01L2300/0654 ,  G01N21/6486 ,  G01N27/07 ,  G01N27/26 ,  G01N33/487 ,  G01N2800/162 ,  G01N2800/24 ,  G06F19/24

摘要： A fluid sample is measured with a tear film measuring system that includes a processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device configured to perform analyses of osmolarity and of one or more biomarkers within the sample fluid, wherein the analysis of biomarkers includes normalization of biomarker concentration values.

摘要翻译： 用泪液测量系统测量流体样品，所述泪液膜测量系统包括处理装置，所述处理装置接收包含被配置为容纳等分试样体积的样品流体的样品区域的样品芯片，所述处理装置被配置为进行渗透压的分析和一种或多种生物标志物 在样品流体中，其中生物标志物的分析包括生物标志物浓度值的归一化。