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    PERSONAL CARE COMPOSITION FOR A KERATIN SUBSTRATE COMPRISING CONDITIONING AND/OR STYLING POLYMER
    2.
    发明申请
    PERSONAL CARE COMPOSITION FOR A KERATIN SUBSTRATE COMPRISING CONDITIONING AND/OR STYLING POLYMER 审中-公开

    公开(公告)号：US20170266096A1

    公开(公告)日：2017-09-21

    申请号：US15308375

    申请日：2015-05-04

    申请人： HERCULES INNCORPORATED

    发明人： Gijsbert Kroon ,  Amna KHATUN ,  Tuttu Maria Nuutinen ,  Michael FRANZKE

    IPC分类号： A61K8/81 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q5/06

    CPC分类号： A61K8/817 ,  A61K8/8147 ,  A61K8/8152 ,  A61K8/8182 ,  A61K8/86 ,  A61K2800/5426 ,  A61Q5/004 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  C08F2218/22 ,  C08F220/06 ,  C08F2220/286 ,  C08F226/06

    摘要： A personal care conditioning and/or styling composition for a keratin substrate comprising: (A) at least one conditioning and/or styling ter/tetra polymer obtained by polymerizing: (i) about 50 wt. % to 97 wt. % of at least one cationic or pseudo-cationic monomer selected from the group consisting of diallyl dimethyl ammonium chloride (DADMAC), Hydroxyethyl-pyrrolidone-methacrylate (MO6), and/or Vinylpyrrolidone (VP); (ii) about 1 wt. % to 30 wt. % of at least one anionic monomer selected from the group consisting of (a) acrylic acid (AA), (b) acrylamido methylpropyl sulfonate (AMPS), and/or (c) sodium methyl allyl sulfonate (SMAS); and (iii) about 0.1 wt. % to 20 wt. % of at least one hydrophobic monomer selected from the group consisting of (a) polyoxyethylene (PEG)-18-behenylether-methacrylate (BEM) (b) Lauryl-ethoxylated-methacrylate (LEM), (c) stearyl acrylate (SA), (d) Streath-10-allyl-ether, and/or (e) Vinylcaprolactam (V-cap); and wherein said ter/tetra polymer has a cationic degree of substitution (Cat-DS) of greater than about 0.001 units, and wherein the cationic charge density is in the range of about 1 meq/g to about 6.5 meq/g; (B) at least one cosmetically acceptable excipient; and (C) optionally, at least one effective amount of personal care active ingredient. Also, disclosed is a process of preparing said ter/tetra polymer, and its method of use.

    IMPROVED NVF COPOLYMER PROCESS
    3.
    发明申请
    IMPROVED NVF COPOLYMER PROCESS 审中-公开
    改进的NVF共聚物工艺

    公开(公告)号：US20110160418A1

    公开(公告)日：2011-06-30

    申请号：US12998026

    申请日：2009-09-11

    申请人： Richard Vicari ,  Florin Barsan ,  Kien Van Phung

    发明人： Richard Vicari ,  Florin Barsan ,  Kien Van Phung

    IPC分类号： C08F226/02

    CPC分类号： C08F8/12 ,  C08F218/08 ,  C08F2218/22

    摘要： Disclosed herein is a water-soluble copolymer formed by copolymerizing N-vinylformamide and one or more vinyl C1-C10 alkyl esters, and then hydrolyzing from 30 to 100 mol % of the formyl groups from the copolymerized units to form amino groups and from 30 to 100 mol % of the C1-C10 alkyl ester groups from the copolymerized units to form hydroxyl groups, wherein the copolymer has a unimodal molecular weight distribution as evidenced by essentially one peak in a gel permeation gradient elution chromatographic analysis. A process to produce the polymer is also disclosed.

    摘要翻译： 本文公开了通过将N-乙烯基甲酰胺和一种或多种乙烯基C1-C10烷基酯共聚而形成的水溶性共聚物，然后从共聚单元中将30-100mol％的甲酰基水解形成氨基，并从30至 100摩尔％的来自共聚单元的C 1 -C 10烷基酯基团以形成羟基，其中共聚物具有单峰分子量分布，如在凝胶渗透梯度洗脱色谱分析中基本上一个峰所证明的。 还公开了制备聚合物的方法。

    Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery
    6.
    发明申请
    Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery 有权
    用于体内核酸递送的聚（乙烯基酯）聚合物

    公开(公告)号：US20150283256A1

    公开(公告)日：2015-10-08

    申请号：US14746070

    申请日：2015-06-22

    申请人： Arrowhead Madison Inc.

    发明人： Darren H Wakefield ,  Nicholas A Rossi ,  Dan Sheik

    IPC分类号： A61K47/48 ,  C12N15/113 ,  C08F218/10

    CPC分类号： A61K47/48176 ,  A61K31/7105 ,  A61K47/58 ,  C08F218/04 ,  C08F218/10 ,  C08F2218/22 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/30

    摘要： The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.

    摘要翻译： 本发明涉及膜活性聚（乙烯基酯）聚合物和用于将RNA干扰（RNAi）多核苷酸靶向递送至细胞体内的组合物。 RNAi多核苷酸与聚（乙烯基酯）聚合物缀合，并且可逆地修饰聚合物以实现体内靶向递送。 聚（乙烯基酯）的膜活性提供了RNAi多核苷酸从细胞外部到细胞内的运动。 可逆修饰提供生理反应。