公开(公告)号：US20140235592A1

公开(公告)日：2014-08-21

申请号：US14184224

申请日：2014-02-19

Applicant: Allergan, Inc.

Inventor： Janet A. Takeuchi ,  Ling Li ,  Wha Bin Im

IPC: C07F9/38 ,  C07C237/48

CPC classification number: C07F9/3895 ,  A61K31/136 ,  C07C237/48 ,  C07C2601/02 ,  C07F9/3882

Abstract: The present invention relates to substituted 6-methoxy-4-amino-N-phenyl-2-naphtamides derivatives, processes for preparing them, pharmaceutical compositions to containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

Abstract translation: 本发明涉及取代的6-甲氧基-4-氨基-N-苯基-2-萘甲酰胺衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。

公开(公告)号：US08114857B2

公开(公告)日：2012-02-14

申请号：US12980985

申请日：2010-12-29

Applicant: John L. Wallace ,  Giuseppe Cirino ,  Giuseppe Caliendo ,  Anna Sparatore ,  Vicenzo Santagada ,  Stefano Fiorucci

Inventor： John L. Wallace ,  Giuseppe Cirino ,  Giuseppe Caliendo ,  Anna Sparatore ,  Vicenzo Santagada ,  Stefano Fiorucci

IPC: A61K31/655 ,  A61K31/60 ,  C07C241/00 ,  C07C229/00

CPC classification number: C07C323/59 ,  C07C323/60 ,  C07C327/42 ,  C07C327/48 ,  C07D339/04 ,  C07F9/3895 ,  C07F9/65785

Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

Abstract translation: 本发明提供4-或5-氨基水杨酸的新衍生物和含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物，其可用于治疗肠疾病如炎性肠病（IBD）和 肠易激综合征（IBS）和预防/治疗结肠癌。 更具体地说，这些衍生物包含通过偶氮，酯，酸酐，硫酯或酰胺键与4-或5-氨基水杨酸分子连接的硫化氢释放部分。 此外，本发明提供了制备这些化合物的方法及其用于治疗IBD和IBS以及预防/治疗结肠癌的用途。

公开(公告)号：US07879827B2

公开(公告)日：2011-02-01

申请号：US12368846

申请日：2009-02-10

Applicant: John L. Wallace ,  Giuseppe Cirino ,  Giuseppe Caliendo ,  Anna Sparatore ,  Vincenzo Santagada ,  Stefano Fiorucci

Inventor： John L. Wallace ,  Giuseppe Cirino ,  Giuseppe Caliendo ,  Anna Sparatore ,  Vincenzo Santagada ,  Stefano Fiorucci

IPC: A61K31/655 ,  A61K31/603 ,  A61K31/606 ,  C07C243/10 ,  C07C229/48

CPC classification number: C07C323/59 ,  C07C323/60 ,  C07C327/42 ,  C07C327/48 ,  C07D339/04 ,  C07F9/3895 ,  C07F9/65785

Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

公开(公告)号：US20090233886A1

公开(公告)日：2009-09-17

申请号：US12368846

申请日：2009-02-10

Applicant: John L. Wallace ,  Giuseppe Cirino ,  Giuseppe Caliendo ,  Anna Sparatore ,  Vincenzo Santagada ,  Stefano Fiorucci

Inventor： John L. Wallace ,  Giuseppe Cirino ,  Giuseppe Caliendo ,  Anna Sparatore ,  Vincenzo Santagada ,  Stefano Fiorucci

IPC: A61K31/655 ,  A61K31/198

CPC classification number: C07C323/59 ,  C07C323/60 ,  C07C327/42 ,  C07C327/48 ,  C07D339/04 ,  C07F9/3895 ,  C07F9/65785

Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

Abstract translation: 本发明提供4-或5-氨基水杨酸的新衍生物和含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物，其可用于治疗肠疾病如炎性肠病（IBD）和 肠易激综合征（IBS）和预防/治疗结肠癌。 更具体地说，这些衍生物包含通过偶氮，酯，酸酐，硫酯或酰胺键与4-或5-氨基水杨酸分子连接的硫化氢释放部分。 此外，本发明提供了制备这些化合物的方法及其用于治疗IBD和IBS以及预防/治疗结肠癌的用途。

公开(公告)号：US07498355B2

公开(公告)日：2009-03-03

申请号：US11278395

申请日：2006-03-31

Applicant: John L. Wallace ,  Giuseppe Cirino ,  Giuseppe Caliendo ,  Anna Sparatore ,  Vincenzo Santagada ,  Stefano Fiorucci

Inventor： John L. Wallace ,  Giuseppe Cirino ,  Giuseppe Caliendo ,  Anna Sparatore ,  Vincenzo Santagada ,  Stefano Fiorucci

IPC: A61K31/381 ,  C07D339/04

CPC classification number: C07C323/59 ,  C07C323/60 ,  C07C327/42 ,  C07C327/48 ,  C07D339/04 ,  C07F9/3895 ,  C07F9/65785

Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

Abstract translation: 本发明提供4-或5-氨基水杨酸的新衍生物和含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物，其可用于治疗肠疾病如炎性肠病（IBD）和 肠易激综合征（IBS）和预防/治疗结肠癌。 更具体地说，这些衍生物包含通过偶氮，酯，酸酐，硫酯或酰胺键与4-或5-氨基水杨酸分子连接的硫化氢释放部分。 此外，本发明提供了制备这些化合物的方法及其用于治疗IBD和IBS以及预防/治疗结肠癌的用途。

公开(公告)号：US4164574A

公开(公告)日：1979-08-14

申请号：US842147

申请日：1977-10-14

Applicant: Patrick M. Quinlan

Inventor： Patrick M. Quinlan

IPC: A01N57/18 ,  C02F1/50 ,  C02F5/14 ,  C07F9/38 ,  A01N9/36

CPC classification number: C07F9/3895 ,  A01N57/18 ,  C02F1/50 ,  C02F5/14 ,  C07F9/3817

Abstract: Polyquaternary ammonium methylene phosphonates and uses thereof, particularly as scale inhibitors, chelating agents, bactericides, etc.

公开(公告)号：US3989525A

公开(公告)日：1976-11-02

申请号：US563760

申请日：1975-03-31

Applicant: Wolfgang Hofer ,  Klaus Lurssen

Inventor： Wolfgang Hofer ,  Klaus Lurssen

IPC: A01N57/28 ,  A01G7/00 ,  A01N20060101 ,  C07F20060101 ,  C07F9/22 ,  C07F9/38 ,  C07F9/44 ,  A01N9/36 ,  C07F9/24

CPC classification number: C07F9/44 ,  C07F9/3895

Abstract: New N-isopropyl-2-chloroethane-(thiono)-phosphonic acid ester amides of the general formula: ##EQU1## wherein X is oxygen or sulfur, andR is acetyl or a group of the formula ##EQU2## wherein X' is oxygen or sulfur,R' is alkoxy with 1 to 4 carbon atoms or 2-chloroethyl, andR" is alkoxy or alkylamino, each with 1 to 4 carbon atoms, or an NH.sub.2 --group; andAre outstandingly effective as plant growth regulating agents.

Abstract translation: 新的N-异丙基-2-氯乙烷 - （硫醇） - 膦酸酯酰胺，其通式为：X Cl-CH 2 -CH 2并联角POR（I）异C3H7-HN，其中X为氧或硫，R为乙酰基 或式X'R'平行角P-R“的基团，其中X'为氧或硫，R'为具有1至4个碳原子的烷氧基或2-氯乙基，R”为烷氧基或烷基氨基，各自为 具有1至4个碳原子，或NH 2 - 基团; 并且作为植物生长调节剂是非常有效的。

公开(公告)号：US3600435A

公开(公告)日：1971-08-17

申请号：US3600435D

申请日：1968-01-26

Applicant: GAF CORP

Inventor： RANDALL DAVID I ,  STAHL CLARENCE R

IPC: A01N57/20 ,  C07F9/38 ,  C07F9/40 ,  C07F9/28

CPC classification number: C07F9/3895 ,  C07F9/3808

Abstract: BIS ALIPHATIC PHOSPHORIC ACID ANHYDRIDES REPRESENTED BY THE FORMULA:

R-P(=O)(-OH)-O-P(-OH)(=O)-R''

WHEREIN R AND R'' REPRESENT AN ALKYL GROUP INCLUDING HALO ALKYL GROUPS, OF 1 TO 6 CARBON ATOMS, AND PREFERABLY A 2-HALOALKYL GROUP.

公开(公告)号：US3400151A

公开(公告)日：1968-09-03

申请号：US69411267

申请日：1967-12-28

Applicant: PROCTER & GAMBLE

Inventor： QUIMBY OSCAR T ,  PRENTICE JAMES B

IPC: C07F9/38 ,  C11D3/00 ,  C11D3/36

CPC classification number: C11D3/361 ,  C07F9/3895

公开(公告)号：US20110098257A1

公开(公告)日：2011-04-28

申请号：US12981008

申请日：2010-12-29

Applicant: JOHN L. WALLACE ,  GIUSEPPE CIRINO ,  GIUSEPPE CALIENDO ,  ANNA SPARATORE ,  VINCENZO SANTAGADA ,  STEFANO FIORUCCI

Inventor： JOHN L. WALLACE ,  GIUSEPPE CIRINO ,  GIUSEPPE CALIENDO ,  ANNA SPARATORE ,  VINCENZO SANTAGADA ,  STEFANO FIORUCCI

IPC: A61K31/625 ,  A61P35/00 ,  A61P29/00 ,  A61P1/04

CPC classification number: C07C323/59 ,  C07C323/60 ,  C07C327/42 ,  C07C327/48 ,  C07D339/04 ,  C07F9/3895 ,  C07F9/65785

Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

Abstract translation: 本发明提供4-或5-氨基水杨酸的新衍生物和含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物，其可用于治疗肠疾病如炎性肠病（IBD）和 肠易激综合征（IBS）和预防/治疗结肠癌。 更具体地说，这些衍生物包含通过偶氮，酯，酸酐，硫酯或酰胺键与4-或5-氨基水杨酸分子连接的硫化氢释放部分。 此外，本发明提供了制备这些化合物的方法及其用于治疗IBD和IBS以及预防/治疗结肠癌的用途。