公开(公告)号：US3621011A

公开(公告)日：1971-11-16

申请号：US3621011D

申请日：1969-08-22

申请人： AMERICAN HOME PROD

发明人： RUSSELL PETER B ,  ALBURN HARVEY E ,  GRANT NORMAN H

IPC分类号： A61K31/43 ,  C07D499/74 ,  C07D99/16

CPC分类号： A61K31/43 ,  C07D499/74 ,  Y02P20/55

摘要： The compounds are 6-(2-amino-hexahydro-2-indancarboxamido) penicillanic acids and 6-(1,2,3,4,5,6,7,8,9,10decahydronaphthalene-2-amino-2-carboxamido) pencillanic acids, which have broad spectrum antimicrobial activity against both gram-positive and gram-negative strains of bacteria, including penicillin-resistant staphylococci. The compounds are also characterized by being relatively acid-resistant, thereby to be effective on oral administration, and by low water solubility which makes them useful in repository injectable dosage forms without the necessity for forming salts thereof with organic bases.

公开(公告)号：US20170095580A1

公开(公告)日：2017-04-06

申请号：US15382402

申请日：2016-12-16

申请人： The Regents of the University of California ,  The Research Foundation for the State University of New York

发明人： Jose Manuel Mejia Oneto ,  Maksim Royzen

IPC分类号： A61K51/06 ,  A61K49/00 ,  A61K31/7076 ,  A61K31/43 ,  A61K38/12 ,  A61K51/12 ,  A61K38/14

CPC分类号： A61K51/065 ,  A61K31/43 ,  A61K31/7076 ,  A61K38/12 ,  A61K38/14 ,  A61K47/54 ,  A61K47/542 ,  A61K47/545 ,  A61K47/61 ,  A61K47/665 ,  A61K47/6903 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0073 ,  A61K51/0482 ,  A61K51/0495 ,  A61K51/1213 ,  C07D257/08 ,  C07D311/82 ,  C07D499/74 ,  C07H7/02 ,  C07H15/24 ,  C07H19/167 ,  C07H19/213

摘要： The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.

公开(公告)号：US20100016630A1

公开(公告)日：2010-01-21

申请号：US12438943

申请日：2007-08-24

申请人： Radha Achanath ,  Malladi Srinivas ,  Candadal Seshadri Ramadoss

发明人： Radha Achanath ,  Malladi Srinivas ,  Candadal Seshadri Ramadoss

IPC分类号： C07C59/64 ,  C07C205/04 ,  C07C201/16 ,  C07C51/42

CPC分类号： A61K31/192 ,  C07C65/05 ,  C07C69/157 ,  C07C69/63 ,  C07C205/60 ,  C07C235/64 ,  C07D499/74

摘要： Derivatives of anacardic acid having antimicrobial properties and method for preparing said derivatives. The antimicrobial properties include bacteriostatic and bacteriocidal activity.

摘要翻译： 具有抗微生物性质的漆树酸的衍生物和制备所述衍生物的方法。 抗菌性能包括抑菌和杀菌活性。

公开(公告)号：US3553201A

公开(公告)日：1971-01-05

申请号：US3553201D

申请日：1967-10-03

申请人： AMERICAN HOME PROD

发明人： CLARK DONALD E ,  GRANT NORMAN H ,  ALBURN HARVEY E

IPC分类号： C07D499/74 ,  C07D99/16

CPC分类号： C07D499/74

摘要： THIS INVENTION IS CONCERNED WITH NEW AND NOVEL PARTIALLY DEHYDRATED AND ANHYDROUS 6-(1-AMINOCYCLOALKYLCARBOXAMIDO)PENICILLANIC ACIDS AND PROCESSES FOR THE PREPARATION THEREOF.

公开(公告)号：US20170087258A1

公开(公告)日：2017-03-30

申请号：US15265158

申请日：2016-09-14

申请人： The Regents of the University of California ,  The Research Foundation for The State University of New York

发明人： Jose Manuel Mejia Oneto ,  Maksim Royzen

IPC分类号： A61K51/06 ,  A61K31/43 ,  A61K51/12 ,  A61K38/12 ,  A61K31/7076 ,  A61K38/14 ,  A61K49/00

CPC分类号： A61K51/065 ,  A61K31/43 ,  A61K31/7076 ,  A61K38/12 ,  A61K38/14 ,  A61K47/54 ,  A61K47/542 ,  A61K47/545 ,  A61K47/61 ,  A61K47/665 ,  A61K47/6903 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0073 ,  A61K51/0482 ,  A61K51/0495 ,  A61K51/1213 ,  C07D257/08 ,  C07D311/82 ,  C07D499/74 ,  C07H7/02 ,  C07H15/24 ,  C07H19/167 ,  C07H19/213

摘要： The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.

公开(公告)号：US08338638B2

公开(公告)日：2012-12-25

申请号：US12438943

申请日：2007-08-24

申请人： Radha Achanath ,  Malladi Srinivas ,  Candadal Seshadri Ramadoss

发明人： Radha Achanath ,  Malladi Srinivas ,  Candadal Seshadri Ramadoss

IPC分类号： C07C237/28 ,  C07C65/01 ,  C07C229/54 ,  A01N37/18

CPC分类号： A61K31/192 ,  C07C65/05 ,  C07C69/157 ,  C07C69/63 ,  C07C205/60 ,  C07C235/64 ,  C07D499/74

摘要： Derivatives of anacardic acid having antimicrobial properties and method for preparing said derivatives. The antimicrobial properties include bacteriostatic and bacteriocidal activity.

摘要翻译： 具有抗微生物性质的漆树酸的衍生物和制备所述衍生物的方法。 抗菌性能包括抑菌和杀菌活性。

公开(公告)号：US3717548A

公开(公告)日：1973-02-20

申请号：US3717548D

申请日：1970-10-12

申请人： KYOWA HAKKO KOGYO KK

发明人： NARA T ,  OKACHI R

IPC分类号： C12P37/04 ,  A61K31/43 ,  A61K35/74 ,  C07D499/66 ,  C07D499/74 ,  C12D9/06

CPC分类号： A61K31/43 ,  C07D499/74 ,  Y10S435/828 ,  Y10S435/859 ,  Y10S435/872 ,  Y10S435/874 ,  Y10S435/913 ,  Y10S435/933 ,  Y10S435/947

摘要： An enzymatic process for the preparation of aminocyclohexylpenicillin is disclosed. The process involves reacting together 6-aminopenicillanic acid or other penicillins and aminocyclohexyl carboxylic acid, or esters and/or acid addition salts thereof in the presence of an enzyme elaborated by such microorganisms as are found in the genera Pseudomonas, Kluyvera, Escherichia, Aerobacter, Micrococcus, Streptomyces, Nocardia, Aspergillus or Penicillium.

摘要翻译： 公开了一种用于制备氨基环己基青霉素的酶促方法。 该方法包括6-氨基青霉烷酸或其他青霉素和氨基环己基羧酸或其酯和/或酸加成盐在由假单胞菌属，克氏乳杆菌属，埃希氏杆菌属，气杆菌属， 微球菌，链霉菌，诺卡氏菌属，曲霉属或青霉属。