公开(公告)号：US5091291A

公开(公告)日：1992-02-25

申请号：US603590

申请日：1990-10-25

Applicant: Philip T. S. Lau ,  Danny R. Thompson

Inventor： Philip T. S. Lau ,  Danny R. Thompson

IPC: C07C235/66 ,  C07C311/05 ,  C07C311/06 ,  C07C311/08 ,  C07C311/09 ,  C07C311/10 ,  C07C311/12 ,  C07C311/18 ,  C07C311/19 ,  C07C311/21 ,  C07C381/14 ,  C07D231/52 ,  G03C7/305 ,  G03C7/32

CPC classification number: G03C7/3212 ,  C07C235/66 ,  C07C311/05 ,  C07C311/06 ,  C07C311/08 ,  C07C311/09 ,  C07C311/10 ,  C07C311/12 ,  C07C311/18 ,  C07C311/19 ,  C07C311/21 ,  C07C381/14 ,  C07D231/52 ,  G03C7/30541

Abstract: A coupler having as a coupling-off group an alkyl group substituted with an electron source capable of stabilizing carbonium ion.

Abstract translation: 具有作为偶合基团的成色剂，被能够稳定碳鎓离子的电子源取代的烷基。

公开(公告)号：US4233238A

公开(公告)日：1980-11-11

申请号：US55788

申请日：1979-07-09

Applicant: Osami Ohura ,  Osamu Fujimoto

Inventor： Osami Ohura ,  Osamu Fujimoto

IPC: C07C381/14 ,  C07C67/00 ,  C07C325/00 ,  C07C145/00

CPC classification number: C07C381/14

Abstract: According to this invention there is provided a process for preparing thiourea dioxide characterized in that in the production of thiourea dioxide by the reaction of thiourea and hydrogen peroxide in an aqueous solvent, the filtrate after separation of the crystals of thiourea dioxide after reaction is treated with an ion-exchange resin to remove side reaction products and impurities contained therein and then is used again as a reaction solvent.

Abstract translation: 根据本发明，提供了一种制备二氧化硫脲的方法，其特征在于在通过硫脲和过氧化氢在水溶剂中反应制备二氧化硫脲二氧化物时，将反应后的二氧化硫脲二氧化钛晶体分离后的滤液用 离子交换树脂，以除去其中所含的副反应产物和杂质，然后再次用作反应溶剂。

公开(公告)号：US07101651B2

公开(公告)日：2006-09-05

申请号：US10776291

申请日：2004-02-12

Applicant: Youichi Ohsawa ,  Katsuhiro Kobayashi ,  Yoshitaka Yanagi ,  Kazunori Maeda

Inventor： Youichi Ohsawa ,  Katsuhiro Kobayashi ,  Yoshitaka Yanagi ,  Kazunori Maeda

IPC: G03F7/004 ,  G03F7/30

CPC classification number: C07C381/14 ,  G03F7/0045 ,  G03F7/0392 ,  G03F7/0395 ,  G03F7/0397 ,  Y10S430/106

Abstract: A chemical amplification type resist composition comprising a specific sulfonyldiazomethane containing long-chain alkoxyl groups has many advantages including improved resolution, improved focus latitude, minimized line width variation or shape degradation even on long-term PED, minimized debris left after coating, development and peeling, and improved pattern profile after development and is thus suited for microfabrication.

Abstract translation: 包含具有长链烷氧基的特定磺酰基重氮甲烷的化学放大型抗蚀剂组合物具有许多优点，包括改进的分辨率，改善的聚焦纬度，最小化的线宽变化或形状退化甚至长期的PED，最小化的碎片在涂布后，显影和剥离 ，并且在显影后改进的图案轮廓，因此适合于微细加工。

公开(公告)号：US4781866A

公开(公告)日：1988-11-01

申请号：US934376

申请日：1986-11-24

Applicant: Cynthia A. Maryanoff ,  James N. Plampin ,  Robin C. Stanzione

Inventor： Cynthia A. Maryanoff ,  James N. Plampin ,  Robin C. Stanzione

IPC: C07C381/14 ,  C07D207/26 ,  C07D207/273 ,  C07D295/215 ,  C07C139/00 ,  C07D239/10

CPC classification number: C07D207/273 ,  C07C381/14 ,  C07D295/215

Abstract: An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): ##STR1## with H.sub.2 O.sub.2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

Abstract translation: 喹啉的有效合成，例如 的式（III）化合物，通过氧化硫脲，例如 的下式（II）：用H 2 O 2和钼催化剂制备氨基亚氨基甲烷磺酸，然后可与胺反应，然后进行任选的转氨步骤。

公开(公告)号：US4610802A

公开(公告)日：1986-09-09

申请号：US660385

申请日：1984-10-12

Applicant: Koichiro Fujiyasu ,  Shigeki Yoneyama ,  Haruhiko Ito

Inventor： Koichiro Fujiyasu ,  Shigeki Yoneyama ,  Haruhiko Ito

IPC: C07C381/14 ,  C07B31/00 ,  C07C67/00 ,  C07C325/00 ,  C07C335/02 ,  C09K3/00

CPC classification number: C07C381/14

Abstract: Activating thiourea dioxide is characterized by incorporating in the thiourea dioxide a substance which dissolves in water or an acidic aqueous solution and produces hydrogen.

Abstract translation: 活化二氧化硫脲的特征在于在二氧化硫脲中引入溶解于水或酸性水溶液中并产生氢的物质。

公开(公告)号：US20070287672A1

公开(公告)日：2007-12-13

申请号：US11587160

申请日：2005-04-20

Applicant: Donald Creighton ,  Donald Creighton ,  Zhe-Bin Zheng

Inventor： Donald Creighton ,  Donald Creighton ,  Zhe-Bin Zheng

IPC: C07C333/00 ,  A61K31/10 ,  A61K38/06 ,  C07C50/22 ,  C08F2/06 ,  C12N5/00 ,  C07K5/08 ,  C07C49/543 ,  A61P35/00

CPC classification number: C07C381/14 ,  A61K31/10 ,  A61K47/00 ,  C07B2200/11

Abstract: This invention relates to macromolecular prodrugs having antitumor activity when activated by GSH, and methods for synthesizing and administering these to patients. More particularly, this invention relates to, inter alia, the synthesis and use of polyacrylamide carriers to target anticancer prodrugs to tumors, and to release active antitumor agents selectively in tumor cells. These active antitumor agents target the active site of the methylglyoxal-detoxifying enzyme glyoxalase I to thereby cause tumor regression.

Abstract translation: 本发明涉及通过GSH活化时具有抗肿瘤活性的大分子前药，以及用于合成和给予患者的方法。 更具体地说，本发明尤其涉及将抗癌前药靶向肿瘤的聚丙烯酰胺载体的合成和用途，以及在肿瘤细胞中选择性释放活性抗肿瘤剂。 这些活性抗肿瘤剂靶向甲基乙二醛解毒酶乙二醛酶I的活性位点，从而引起肿瘤消退。

公开(公告)号：US5149871A

公开(公告)日：1992-09-22

申请号：US797789

申请日：1991-11-25

Applicant: Hirohisa Nitoh ,  Osami Ohura ,  Morio Suzuki

Inventor： Hirohisa Nitoh ,  Osami Ohura ,  Morio Suzuki

IPC: G03C1/09 ,  C07C381/14

CPC classification number: C07C381/14

Abstract: A novel water-soluble produced by contacting thiourea dioxide with an aqueous solution comprising an amino acid having the general formula NH.sub.2 (CH.sub.2).sub.n COOH wherein n is an integer of 1 to 7 and a sodium, potassium or calcium salt of acetic acid.

公开(公告)号：US4943661A

公开(公告)日：1990-07-24

申请号：US323495

申请日：1989-03-14

Applicant: Hirohisa Nitoh ,  Osami Ohura ,  Morio Suzuki

Inventor： Hirohisa Nitoh ,  Osami Ohura ,  Morio Suzuki

IPC: C07C381/14

CPC classification number: C07C381/14

Abstract: An amine-substituted thiourea dioxide is obtained by reacting thiourea dioxide and an aliphatic or aromatic primary amine in a neutral or acidic pH range.

Abstract translation: 通过在中性或酸性pH范围内使二氧化硫脲和脂族或芳族伯胺反应获得胺取代的二氧化硫脲。

公开(公告)号：US4656270A

公开(公告)日：1987-04-07

申请号：US711948

申请日：1985-03-15

Applicant: Cynthia A. Maryanoff ,  James N. Plampin ,  Robin C. Stanzione

Inventor： Cynthia A. Maryanoff ,  James N. Plampin ,  Robin C. Stanzione

IPC: C07D207/22 ,  B01J23/00 ,  C07B61/00 ,  C07C67/00 ,  C07C301/00 ,  C07C303/16 ,  C07C309/16 ,  C07C313/00 ,  C07C335/16 ,  C07C381/14 ,  C07D207/26 ,  C07D207/273 ,  C07D295/14 ,  C07D295/215 ,  C07D295/12 ,  C07D413/12

CPC classification number: C07D207/273 ,  C07C381/14 ,  C07D295/215

Abstract: Novel synthetic steps and intermediates leading to guanidines such as the anti-diabetic compound linogliride. Included is a hydrogen peroxide oxidation of a thiourea (II) to a sulfonic acid (I) which may then be reacted with morpholine to form the carboximidamide (III): ##STR1##

Abstract translation: 新的合成步骤和中间体导致胍如抗糖尿病化合物林格列里。 包括硫脲（II）到磺酸（I）的过氧化氢氧化，然后其可以与吗啉反应以形成甲脒（III）：

公开(公告)号：US4299780A

公开(公告)日：1981-11-10

申请号：US133790

申请日：1980-03-25

Applicant: Young-Jin Lee

Inventor： Young-Jin Lee

IPC: C07C309/14 ,  A01N47/10 ,  C07C67/00 ,  C07C301/00 ,  C07C303/24 ,  C07C143/02 ,  C07C143/52

CPC classification number: C07C381/14

Abstract: This invention relates to a process of preparing a compound of the formula:R-NHCOSO.sub.3.sup.- M.sup.+wherein R is a C.sub.1 --C.sub.8 alkyl or phenyl group andM is an alkali metal or ammonium ion.Also encompassed by the present invention is a novel class of compounds, namely salts of N-methylcarbamoylsulfonic acids.

Abstract translation: 本发明涉及制备下式化合物的方法：R-NHCOSO3-M +，其中R是C1-C8烷基或苯基，M是碱金属或铵离子。 本发明还包括一类新的化合物，即N-甲基氨基甲酰磺酸的盐。