公开(公告)号：US06221866B1

公开(公告)日：2001-04-24

申请号：US09603436

申请日：2000-06-23

Applicant: Joachim Brendel ,  Uwe Gerlach ,  Hans Ulrich Stilz ,  Hans-Jochen Lang

Inventor： Joachim Brendel ,  Uwe Gerlach ,  Hans Ulrich Stilz ,  Hans-Jochen Lang

IPC: A61K31535

CPC classification number: C07D295/26 ,  C07C311/16 ,  C07C311/20 ,  C07C311/21 ,  C07C311/26 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D217/02

Abstract: in which R(1) to R(8) have the meanings stated in the claims, act on the Kv1.5 potassium channel, and inhibit a potassium current, referred to as “ultra-rapidly activating delayed rectifier,” in the human atrium. They are therefore very particularly suitable as novel antiarrhythmic active substances, in particular for the treatment and prophylaxis of atrial arrhythmias, e.g., atrial fibrillation or atrial flutter.

Abstract translation: 其中R（1）至R（8）具有权利要求中所述的含义，作用于Kv1.5钾通道，并抑制在人心房中称为“超快速活化延迟整流剂”的钾电流 。 因此，它们特别适合作为新型抗心律失常活性物质，特别是用于治疗和预防房性心律失常，例如房颤或心房颤动。