公开(公告)号：US09956179B2

公开(公告)日：2018-05-01

申请号：US13368888

申请日：2012-02-08

Applicant: Brian K. Johnson ,  Robert K. Prud'homme

Inventor： Brian K. Johnson ,  Robert K. Prud'homme

IPC: A61K9/14 ,  A61K9/51 ,  A01N25/04 ,  A01N43/70 ,  A61K47/34 ,  B01F7/22 ,  B01F15/00 ,  B01J13/00 ,  B01F1/00

CPC classification number: A61K9/5138 ,  A01N25/04 ,  A01N43/70 ,  A61K9/5146 ,  A61K9/5192 ,  A61K47/34 ,  B01F1/00 ,  B01F7/22 ,  B01F15/00123 ,  B01F15/00344 ,  B01F15/00357 ,  B01F15/00376 ,  B01F15/00396 ,  B01J13/0021 ,  A01N2300/00

Abstract: This invention discloses a process for making nanoparticles of amphiphilic copolymers by flash precipitation. Nanoparticles may be of amphiphilic copolymer alone or may contain an additive target molecule, preferably an organic active. The inclusion of additive target molecules in amphiphilic copolymer nanoparticles can alter their water solubility characteristics, fluid dynamics, and/or stability. Changing an additive target molecule's solubility and stability in a nanoparticle can make a water insoluble compound suitable for pharmaceutical administration as well as specifically target the molecule to a specific area of a patient's body. The process affords the production of nanoparticles at high absolute active content, at high yield, high productivity, and high processing rates while using unusually low amounts of amphiphilic copolymers. Furthermore, the resulting particles exhibit sufficient stability for post processing as desired. The invention also discloses two apparatuses for the production of nanoparticles of amphiphilic copolymers by flash precipitation.

公开(公告)号：US09333471B2

公开(公告)日：2016-05-10

申请号：US13836488

申请日：2013-03-15

Applicant: STAT-DIAGNOSTICA & INNOVATION, S.L.

Inventor： Jordi Carrera Fabra ,  Anna Comengés Casas ,  Rafael Bru Gibert ,  Marta López Fontanals ,  Gemma Pueyo Castells ,  Rupert Maxwell Gaut

IPC: B02C17/24 ,  B01F13/08 ,  B01F11/00 ,  B01F13/00 ,  B01F15/00 ,  C12N1/06 ,  C12M1/00

CPC classification number: B01F13/08 ,  B01F11/0082 ,  B01F13/0052 ,  B01F13/0818 ,  B01F15/00376 ,  B01F15/00876 ,  B01F2215/0481 ,  B02C17/24 ,  C12M47/06 ,  C12M47/08 ,  C12N1/066

Abstract: A system for at least one of homogenization and lysis of a sample includes one or more walls forming an enclosed chamber, a permanent magnet within the enclosed chamber, a magnet guide, and one or more magnets located outside the chamber. The enclosed chamber has an inlet and one or more fluidic connections configured to introduce at least the sample into the chamber. The permanent magnet has a positive pole and a negative pole. The magnet guide is configured to laterally guide the permanent magnet between a first position and a second position and maintain a substantially constant orientation of the permanent magnet during the movement. Movement of the magnets outside the chamber changes a magnetic field between the one or more magnets and the permanent magnet. The permanent magnet moves between the first and second positions in response to the changing magnetic field.

Abstract translation: 用于样品的均化和裂解中的至少一种的系统包括形成封闭室的一个或多个壁，封闭室内的永久磁体，磁体引导件和位于室外的一个或多个磁体。 封闭室具有入口和一个或多个流体连接，其构造成将至少将样品引入室中。 永磁体具有正极和负极。 磁体引导件构造成在第一位置和第二位置之间横向地引导永磁体，并且在运动期间保持永磁体的基本上恒定的取向。 在室外的磁体的运动改变了一个或多个磁体和永磁体之间的磁场。 永磁体响应于变化的磁场在第一和第二位置之间移动。

公开(公告)号：US20160067657A1

公开(公告)日：2016-03-10

申请号：US14933018

申请日：2015-11-05

Applicant: Mixer Technologies Inc.

Inventor： Shawn P. Steffler ,  Donald D. Savard

IPC: B01F5/02 ,  B01F15/00

CPC classification number: B01F5/0281 ,  B01F5/0218 ,  B01F5/0231 ,  B01F15/00123 ,  B01F15/00201 ,  B01F15/00376 ,  G01P3/02 ,  G01P3/12

Abstract: A mixer nozzle assembly for mixing fluid introduced into a tank having a tank volume therein. The mixer nozzle assembly includes a stationary body and a rotatable body mounted on the stationary body for rotation about an axis in a predetermined direction. The fluid flows through the stationary body to the rotatable body and exits into the tank volume via one or more outlet apertures, thereby causing the rotatable body to rotate in the predetermined direction about the axis. The mixer nozzle assembly also includes a governor subassembly for controlling a speed of rotation of the rotatable body in the predetermined direction about the axis.

Abstract translation: 一种混合器喷嘴组件，用于混合引入其中具有罐体积的罐中的流体。 混合器喷嘴组件包括固定体和安装在固定体上的旋转体，用于围绕预定方向的轴线旋转。 流体通过静止体流动到可转动的主体并通过一个或多个出口孔离开到容器体积中，从而使可旋转体围绕轴线沿预定方向旋转。 混合器喷嘴组件还包括调节器子组件，用于控制旋转体在围绕轴线的预定方向上的旋转速度。

公开(公告)号：US20130272087A1

公开(公告)日：2013-10-17

申请号：US13836488

申请日：2013-03-15

Applicant: STAT-DIAGNOSTICA & INNOVATION, S.L.

Inventor： Jordi CARRERA FABRA ,  Anna Comenges Casas ,  Rafael Bru Bibert ,  Marta Lòpez Fontanals ,  Gemma Pueyo Castells ,  Rupert Mexwell Gaut

IPC: B01F13/08

CPC classification number: B01F13/08 ,  B01F11/0082 ,  B01F13/0052 ,  B01F13/0818 ,  B01F15/00376 ,  B01F15/00876 ,  B01F2215/0481 ,  B02C17/24 ,  C12M47/06 ,  C12M47/08 ,  C12N1/066

Abstract: A system for at least one of homogenization and lysis of a sample includes one or more walls forming an enclosed chamber, a permanent magnet within the enclosed chamber, a magnet guide, and one or more magnets located outside the chamber. The enclosed chamber has an inlet and one or more fluidic connections configured to introduce at least the sample into the chamber. The permanent magnet has a positive pole and a negative pole. The magnet guide is configured to laterally guide the permanent magnet between a first position and a second position and maintain a substantially constant orientation of the permanent magnet during the movement. Movement of the magnets outside the chamber changes a magnetic field between the one or more magnets and the permanent magnet. The permanent magnet moves between the first and second positions in response to the changing magnetic field.

Abstract translation: 用于样品的均化和裂解中的至少一种的系统包括形成封闭室的一个或多个壁，封闭室内的永久磁体，磁体引导件和位于室外的一个或多个磁体。 封闭室具有入口和一个或多个流体连接，其构造成将至少将样品引入室中。 永磁体具有正极和负极。 磁体引导件构造成在第一位置和第二位置之间横向地引导永磁体，并且在运动期间保持永磁体的基本上恒定的取向。 在室外的磁体的运动改变了一个或多个磁体和永磁体之间的磁场。 永磁体响应于变化的磁场在第一和第二位置之间移动。

公开(公告)号：US20120171254A1

公开(公告)日：2012-07-05

申请号：US13368888

申请日：2012-02-08

Applicant: Brian K. Johnson ,  Robert K. Prud'homme

Inventor： Brian K. Johnson ,  Robert K. Prud'homme

IPC: A61K9/14 ,  A61P39/06 ,  A61K31/015 ,  A61K47/34 ,  B82Y40/00 ,  B82Y5/00

CPC classification number: A61K9/5138 ,  A01N25/04 ,  A01N43/70 ,  A61K9/5146 ,  A61K9/5192 ,  A61K47/34 ,  B01F1/00 ,  B01F7/22 ,  B01F15/00123 ,  B01F15/00344 ,  B01F15/00357 ,  B01F15/00376 ,  B01F15/00396 ,  B01J13/0021 ,  A01N2300/00

Abstract: This invention discloses a process for making nanoparticles of amphiphilic copolymers by flash precipitation. Nanoparticles may be of amphiphilic copolymer alone or may contain an additive target molecule, preferably an organic active. The inclusion of additive target molecules in amphiphilic copolymer nanoparticles can alter their water solubility characteristics, fluid dynamics, and/or stability. Changing an additive target molecule's solubility and stability in a nanoparticle can make a water insoluble compound suitable for pharmaceutical administration as well as specifically target the molecule to a specific area of a patient's body. The process affords the production of nanoparticles at high absolute active content, at high yield, high productivity, and high processing rates while using unusually low amounts of amphiphilic copolymers. Furthermore, the resulting particles exhibit sufficient stability for post processing as desired. The invention also discloses two apparatuses for the production of nanoparticles of amphiphilic copolymers by flash precipitation.

Abstract translation: 本发明公开了一种通过闪蒸沉淀制备两亲性共聚物的纳米颗粒的方法。 纳米颗粒可以单独使用两亲性共聚物，也可以含有添加剂目标分子，优选为有机活性物质。 在两亲共聚物纳米颗粒中包含添加剂靶分子可以改变其水溶性特征，流体动力学和/或稳定性。 改变添加剂目标分子在纳米颗粒中的溶解度和稳定性可使得适合于药物给药的水不溶性化合物以及将该分子特异性地靶向患者身体的特定区域。 该方法以高绝对活性含量，高产率，高生产率和高加工速率生产纳米颗粒，同时使用异常少量的两亲性共聚物。 此外，所得到的颗粒根据需要显示出足够的后处理稳定性。 本发明还公开了通过闪蒸沉淀生产两亲性共聚物的纳米颗粒的两种装置。

公开(公告)号：US20120039148A1

公开(公告)日：2012-02-16

申请号：US13208879

申请日：2011-08-12

Applicant: Shawn P. Steffler ,  Donald D. Savard ,  Donna Savard

Inventor： Shawn P. Steffler ,  Donald D. Savard ,  Donna Savard

IPC: B01F15/02

CPC classification number: B01F5/0281 ,  B01F5/0218 ,  B01F5/0231 ,  B01F15/00123 ,  B01F15/00201 ,  B01F15/00376 ,  G01P3/02 ,  G01P3/12

Abstract: A mixer nozzle assembly for mixing fluid introduced into a tank having a tank volume therein. The mixer nozzle assembly includes a stationary body and a rotatable body mounted on the stationary body for rotation about an axis in a predetermined direction. The fluid flows through the stationary body to the rotatable body and exits into the tank volume via one or more outlet apertures for causing the rotatable body to rotate in the predetermined direction about the axis. The mixer nozzle assembly also includes a governor subassembly for controlling a speed of rotation of the rotatable body in the predetermined direction about the axis and a hydraulic circuit for governing a flow rate of hydraulic fluid directed to the governor subassembly, to adjust the flow rate of the hydraulic fluid for adjusting the speed of rotation of the rotatable body to the preselected speed.

Abstract translation: 一种混合器喷嘴组件，用于混合引入其中具有罐体积的罐中的流体。 混合器喷嘴组件包括固定体和安装在固定体上的旋转体，用于围绕预定方向的轴线旋转。 流体通过静止体流动到可旋转体并通过一个或多个出口孔离开到容器体积中，以使可旋转体围绕轴线在预定方向上旋转。 混合器喷嘴组件还包括调节器子组件，用于控制可旋转体在围绕轴线的预定方向上的旋转速度，以及用于控制指向调速器子组件的液压流体的流量的液压回路，以调节 用于将可旋转体的旋转速度调节到预选速度的液压流体。

公开(公告)号：US20090107196A1

公开(公告)日：2009-04-30

申请号：US11924634

申请日：2007-10-26

Applicant: Philip O. Jung

Inventor： Philip O. Jung

IPC: C05C1/02

CPC classification number: C05B7/00 ,  B01F7/00116 ,  B01F7/00175 ,  B01F7/18 ,  B01F7/20 ,  B01F15/00207 ,  B01F15/00246 ,  B01F15/00376 ,  B01J2/02 ,  C05C1/02 ,  G01N11/08 ,  Y10S366/601 ,  C05C3/005 ,  C05C9/005 ,  C05D1/02 ,  C05D9/02

Abstract: A method of prilling or spray drying comprising calculating and controlling the viscosity of a shear-thinnable fluid stream at a particle-forming section of a dispersion device. The method comprises measuring the static head of fluid in the dispersion device, providing a pressurized blanket of inert gas over the fluid, mechanically agitating the fluid in the dispersion device, calculating the viscosity at the particle-forming section and controlling the viscosity by adjusting the speed of mechanical agitation.

Abstract translation: 造粒或喷雾干燥的方法包括计算和控制在分散装置的颗粒形成部分处的可剪切稀释流体流的粘度。 该方法包括测量分散装置中的静态流体头部，在流体上提供惰性气体的加压覆盖层，机械地搅拌分散装置中的流体，计算颗粒形成部分处的粘度并通过调节粘度 机械搅拌速度。

公开(公告)号：US20090067282A1

公开(公告)日：2009-03-12

申请号：US12268557

申请日：2008-11-11

Applicant: LaVon Wenger ,  Marc Wenger ,  Galen J. Rokey

Inventor： LaVon Wenger ,  Marc Wenger ,  Galen J. Rokey

IPC: B01F7/00

CPC classification number: B01F7/042 ,  B01F7/00425 ,  B01F7/043 ,  B01F15/00194 ,  B01F15/00253 ,  B01F15/00376 ,  Y10S366/601 ,  Y10S388/936

Abstract: An improved, dual-shaft preconditioner (10, 70, 102) is provided having independent drive mechanism (18, 20, 78, 80) operatively coupled with a corresponding preconditioner shaft (14, 16, 74, 76, 106, 108) and permitting selective rotation of the shafts (14, 16, 74, 76, 106, 108) at rotational speeds and directions independent of each other. Preferably, the speed differential between the shafts (14, 16, 74, 76, 106, 108) is at least about 5:1. The mechanisms (18, 20, 78, 80) are operatively coupled with a digital control device (60) to allow rotational speed and direction control. Preferably, the preconditioner (10, 70, 102) is supported on load cells (62, 100) also coupled with control device (60) to permit on-the-go changes in material retention time within the preconditioner (10, 70, 102). The preconditioner (10, 70, 102) is particularly useful for the preconditioning and partial gelatinization of starch-bearing feed or food materials, to an extent to achieve at least about 50% cook in the preconditioned feed or food materials.

Abstract translation: 提供了一种改进的双轴预调节器（10,70,102），其具有与相应的预调节器轴（14,16,74,76,106,108）可操作地联接的独立的驱动机构（18,20,78,80）和 允许轴（14,16,74,76,106,108）以独立于彼此的旋转速度和方向选择性地旋转。 优选地，轴（14,16,74,76,106,108）之间的速度差为至少约5:1。 机构（18,20,78,80）可操作地与数字控制装置（60）耦合以允许转速和方向控制。 优选地，预调节器（10,70,102）被支撑在也与控制装置（60）耦合的称重传感器（62,100）上，以允许预处理器（10,70,102）内的材料保持时间的随时变化 ）。 预处理剂（10,70,102）对于含淀粉的饲料或食品材料的预处理和部分糊化特别有用，达到在预处理的饲料或食品材料中达到至少约50％煮熟的程度。

公开(公告)号：US07448795B2

公开(公告)日：2008-11-11

申请号：US11551997

申请日：2006-10-23

Applicant: LaVon Wenger ,  Marc Wenger ,  Michael J. Strahm

Inventor： LaVon Wenger ,  Marc Wenger ,  Michael J. Strahm

IPC: B01F7/04

CPC classification number: B01F7/042 ,  B01F7/043 ,  B01F15/00194 ,  B01F15/00253 ,  B01F15/00376 ,  Y02P70/32 ,  Y10S366/601 ,  Y10S388/936

Abstract: An improved, dual-shaft preconditioner (10, 70) is provided having independent drive mechanism (18, 20, 78, 80) operatively coupled with a corresponding preconditioner shaft (14, 16, 74, 76) and permitting selective rotation of the shafts (14, 16, 74, 76) at rotational speeds and directions independent of each other. The mechanisms (18, 20, 78, 80) are operatively coupled with a digital controller (60) to allow rotational speed and direction control. Preferably, the preconditioner (10, 70) is supported on load cells (62, 100) also coupled with controller (60) to permit on-the-go changes in material retention time within the preconditioner (10, 70). The preconditioner (10, 70) is particularly useful for the preconditioning and partial gelatinization of starch-bearing feed or food materials.

Abstract translation: 提供了一种改进的双轴预调节器（10,70），其具有与相应的预调节器轴（14,16,74,76）可操作地联接的独立的驱动机构（18,20,78,80），并允许轴的选择性旋转 （14,16,74,76）的旋转速度和方向彼此独立。 机构（18,20,78,80）与数字控制器（60）可操作地耦合以允许转速和方向控制。 优选地，预处理器（10,70）被支撑在也与控制器（60）耦合的称重传感器（62,100）上，以允许预处理器（10,70）内的材料保持时间的随时变化。 预处理剂（10,70）对含淀粉饲料或食品材料的预处理和部分糊化特别有用。

公开(公告)号：US20080094939A1

公开(公告)日：2008-04-24

申请号：US11551997

申请日：2006-10-23

Applicant: LaVon Wenger ,  Marc Wenger ,  Michael J. Strahm

Inventor： LaVon Wenger ,  Marc Wenger ,  Michael J. Strahm

IPC: B01F7/04

CPC classification number: B01F7/042 ,  B01F7/043 ,  B01F15/00194 ,  B01F15/00253 ,  B01F15/00376 ,  Y02P70/32 ,  Y10S366/601 ,  Y10S388/936

Abstract: An improved, dual-shaft preconditioner (10, 70) is provided having independent drive mechanism (18, 20, 78, 80) operatively coupled with a corresponding preconditioner shaft (14, 16, 74, 76) and permitting selective rotation of the shafts (14, 16, 74, 76) at rotational speeds and directions independent of each other. The mechanisms (18, 20, 78, 80) are operatively coupled with a digital controller (60) to allow rotational speed and direction control. Preferably, the preconditioner (10, 70) is supported on load cells (62, 100) also coupled with controller (60) to permit on-the-go changes in material retention time within the preconditioner (10, 70). The preconditioner (10, 70) is particularly useful for the preconditioning and partial gelatinization of starch-bearing feed or food materials.

Abstract translation: 提供了一种改进的双轴预调节器（10,70），其具有与相应的预调节器轴（14,16,74,76）可操作地联接的独立的驱动机构（18,20,78,80），并允许轴的选择性旋转 （14,16,74,76）的旋转速度和方向彼此独立。 机构（18,20,78,80）与数字控制器（60）可操作地耦合以允许转速和方向控制。 优选地，预处理器（10,70）被支撑在也与控制器（60）耦合的称重传感器（62,100）上，以允许预处理器（10,70）内的材料保持时间的随时变化。 预处理剂（10,70）对含淀粉饲料或食品材料的预处理和部分糊化特别有用。