公开(公告)号：US08207142B2

公开(公告)日：2012-06-26

申请号：US10485438

申请日：2002-07-30

Applicant: Eric U. Selker ,  Cindy B. Matsen ,  Peter A. Jones ,  Jonathan Cheng ,  Sheldon B. Greer ,  Victor E. Marquez

Inventor： Eric U. Selker ,  Cindy B. Matsen ,  Peter A. Jones ,  Jonathan Cheng ,  Sheldon B. Greer ,  Victor E. Marquez

IPC: A61K31/7068

CPC classification number: A61K31/7068 ,  A61K31/513 ,  A61K31/7072 ,  A61K31/7088 ,  A61K45/06 ,  C07H19/06 ,  C07H21/00 ,  A61K2300/00

Abstract: Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions through the application of 2-pyrimidinone derivatives, such as Zebularine. Compositions, including pharmaceutical compositions, comprising such derivatives are also provided. Also provided are kits for use in inhibiting DNA methylation, which kits include an amount of a 2-pyrimidinone derivative.

Abstract translation: Zebularine具有低甲基化活性，可用于体内和体外抑制，逆转和/或减少DNA甲基化。 提供了通过施用2-嘧啶酮衍生物如Zebularine来治疗甲基化连接的病症的方法。 还提供了包含这些衍生物的组合物，包括药物组合物。 还提供了用于抑制DNA甲基化的试剂盒，该试剂盒包括一定量的2-嘧啶酮衍生物。

公开(公告)号：US20110149739A1

公开(公告)日：2011-06-23

申请号：US13060826

申请日：2009-08-26

Applicant: Dilip Sarkar

Inventor： Dilip Sarkar

IPC: H04W28/08

CPC classification number: H04W28/08 ,  H04W84/12

Abstract: Access for wireless mobile nodes (WMNs) to access points (APs) may be provided via a wireless network where each WMN is associated with a plurality of APs, according to an exemplary embodiment.

Abstract translation: 根据示例性实施例，无线移动节点（WMN）到接入点（AP）的接入可以经由无线网络提供，其中每个WMN与多个AP相关联。

公开(公告)号：US12133683B2

公开(公告)日：2024-11-05

申请号：US17393101

申请日：2021-08-03

Applicant: UNIVERSITY OF MIAMI

Inventor： Mohamed Abou Shousha

IPC: A61B3/024 ,  A61B3/02 ,  A61B3/028 ,  A61B3/06 ,  G06N3/02 ,  G16H50/20 ,  G16H50/30

Abstract: Methods and systems for dynamically determining stimuli characteristics for vision defect determination during a vision test. The methods and systems convert the feedback received from the binary suprathreshold test into a feature input that is provided to a prediction model. The prediction model may be trained to predict non-binary characteristics for sets of locations and confidence scores associated with the sets of locations based on feedback indicating binary characteristics under which users see one or more stimuli presented on user interfaces.

公开(公告)号：US20240293501A1

公开(公告)日：2024-09-05

申请号：US18002480

申请日：2021-06-21

Applicant: Michael J. PAIDAS ,  Arumugam JAYAKUMAR ,  University of Miami

Inventor： Michael J. Paidas ,  Arumugam Jayakumar

IPC: A61K38/10 ,  A61P31/12

CPC classification number: A61K38/10 ,  A61P31/12

Abstract: This invention provides reagents, pharmaceutical formulations comprising such reagents, and methods for preventing and treating viral infections, specifically coronavirus infections, and in particular infections in humans with COVID-19.

公开(公告)号：US12066512B2

公开(公告)日：2024-08-20

申请号：US17295528

申请日：2019-11-20

Applicant: Emory University ,  University of Miami

Inventor： Hyunsuk Shim ,  Lee Cooper ,  Saumya Gurbani ,  Andrew Maudsley ,  Sulaiman Sheriff

IPC: G01R33/485 ,  G01R33/46 ,  G06N3/045 ,  G06N3/084

CPC classification number: G01R33/485 ,  G01R33/4625 ,  G06N3/045 ,  G06N3/084

Abstract: Systems and methods provide a parallelized deep learning approach to spectral fitting for magnetic resonance spectroscopy data enabling accurate and rapid spectral fitting and determination of metabolite measurements using a conventional computer. The method may include processing multi-spectra magnetic resonance (MR) spectroscopy data of a region of interest through a series of neural networks. The method may include determining baseline components of each spectrum using a first neural network of the series, generating baseline-corrected components for each spectrum using the baseline components; and determining one or more peak components of each spectrum using a second neural network of the series and the baseline-corrected components. The method may further include determining one or more metabolite measurements of the one or more metabolites in the region of interest using the one or more peak components.

公开(公告)号：US12029706B2

公开(公告)日：2024-07-09

申请号：US17021185

申请日：2020-09-15

Applicant: UNIVERSITY OF MIAMI

Inventor： Shaun Brothers ,  Claes Wahlestedt ,  Claude Henry Volmar

IPC: A61K31/05 ,  A61K9/00 ,  A61K31/03 ,  A61K31/09 ,  A61K31/166 ,  A61K31/185 ,  A61K31/194 ,  A61K31/235 ,  A61K31/36 ,  A61K31/423 ,  A61K31/69 ,  A61K31/7004 ,  A61K45/06 ,  A61P3/00

CPC classification number: A61K31/05 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/03 ,  A61K31/09 ,  A61K31/166 ,  A61K31/185 ,  A61K31/194 ,  A61K31/235 ,  A61K31/36 ,  A61K31/423 ,  A61K31/69 ,  A61K31/7004 ,  A61K45/06 ,  A61P3/00

Abstract: The present invention provides methods and compositions for the treatment of mucopolysaccharidoses (MPS).

公开(公告)号：US20240158801A1

公开(公告)日：2024-05-16

申请号：US18393461

申请日：2023-12-21

Applicant: UNIVERSITY OF MIAMI

Inventor： Glen N Barber

IPC: C12N15/117 ,  A61K9/127 ,  A61K31/713 ,  A61K39/00 ,  A61K39/39 ,  A61P35/00 ,  B82Y5/00 ,  C12N5/0784 ,  C12N15/88

CPC classification number: C12N15/117 ,  A61K9/127 ,  A61K31/713 ,  A61K39/0011 ,  A61K39/39 ,  A61K39/4615 ,  A61K39/4622 ,  A61K39/464499 ,  A61P35/00 ,  B82Y5/00 ,  C12N5/0639 ,  C12N15/88 ,  A61K2039/5152 ,  A61K2039/55561 ,  A61K2039/585 ,  C12N2501/2301 ,  C12N2501/25 ,  C12N2502/30 ,  C12N2502/99

Abstract: Activation of STimulator of INterferon Genes (STING) triggers cytokine production and facilitates tumor antigen cross-presentation. In an embodiment of the present invention, STING-dependent innate immune signaling pathway activators (STAVs) can be delivered to antigen presenting cells. In various embodiments of the present invention, the STAVs can be delivered in lipid nanoparticle formulations. In various embodiments of the present invention, the range of cancers amenable to STAV therapy can be extended using a non-cell-based nanoparticle strategy that effectively delivers Nano-STAVs into the Tumor Micro Environment (TME) to potently generate anti-tumor cytotoxic T cell activity. The STAV formulations can be introduced into solid tumors present in the mammal. Alternatively, the Nano-STAVs can be introduced through direct inoculation. The lipid nanoparticles stick to the tumor cells and are co-phagocytosed to activate STING in APC's.

公开(公告)号：US11981660B2

公开(公告)日：2024-05-14

申请号：US16982946

申请日：2019-03-21

Applicant: UNIVERSITY OF MIAMI ,  Torrey Pines Institute for Molecular Studies

Inventor： Vance Lemmon ,  Hassan Al-Ali ,  John Bixby ,  Marc Giulianotti

IPC: C07D403/06

CPC classification number: C07D403/06

Abstract: Provided herein are compounds useful in treating a central nervous system disorder associated with neuronal and/or axonal damage, methods for their preparation, and related pharmaceutical compositions. For example provided herein are compounds of Formula (I): and pharmaceutically acceptable salts and compositions including the same.

公开(公告)号：US20240124568A1

公开(公告)日：2024-04-18

申请号：US18187960

申请日：2023-03-22

Applicant: University of Miami

Inventor： Scott Welford

IPC: C07K16/24 ,  A61K31/7105 ,  A61P35/00 ,  C12N9/22 ,  C12N15/11

CPC classification number: C07K16/24 ,  A61K31/7105 ,  A61P35/00 ,  C12N9/22 ,  C12N15/11 ,  A61K2039/505

Abstract: The present disclosure relates to chemerin inhibitors and uses thereof for treating, preventing, and detecting cancer.

公开(公告)号：US11913962B2

公开(公告)日：2024-02-27

申请号：US16613411

申请日：2018-05-14

Applicant: UNIVERSITY OF MIAMI

Inventor： Krishna Komanduri ,  Eric Wieder ,  Jose Camargo ,  Erik Kimble

IPC: G01N33/68

CPC classification number: G01N33/6863 ,  G01N2333/03 ,  G01N2333/523 ,  G01N2333/525 ,  G01N2333/55 ,  G01N2333/57 ,  G01N2800/245

Abstract: Described herein are materials and methods for stratifying risk for reactivation of a latent viral infection, such as CMV infection. The methods are particularly useful for immune compromised subjects. Also described herein are interventions, including therapeutic, prophylactic, and monitoring interventions, for subjects determined to be at elevated risk.