-
公开(公告)号：US20200171145A1
公开(公告)日：2020-06-04
申请号：US16783639
申请日：2020-02-06
Inventor： Kari C. Nadeau
IPC: A61K39/35 , A61K9/00 , A61K31/59 , A61K39/005 , A61K45/06 , A61K47/10 , A61K47/44 , A61K47/46 , A61K35/60 , A61K35/747 , A61K9/14 , A61K31/375 , A61K31/593
Abstract: Mixed allergen compositions of two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin. Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.
-
公开(公告)号：US20180224557A1
公开(公告)日：2018-08-09
申请号：US15507860
申请日：2015-09-04
Inventor： Emily McMilin , David S. De Lorenzo , Per K. Enge , Dennis M. Akos
Abstract: There is provided an apparatus comprising an antenna (105) configured to receive a signal from a global navigation satellite system, wherein the antenna includes a first feed and a second feed; a hybrid coupler (110) including a first hybrid input, a second hybrid input, a first hybrid output, a second hybrid output, and wherein the first hybrid output is shifted in phase by 90 degrees relative to the second hybrid output; a variable phase shifter (150) including a shifter input and a shifter output, hybrid output; and a combiner (155) including a first combiner input, a second combiner input, and a combiner output, wherein the first combiner input is coupled to the shifter output, and the second combiner input is coupled to the second hybrid output, and wherein the combiner output is provided to detection circuitry (197).
-
3.发明申请公开(公告)号：US20180100865A1
公开(公告)日：2018-04-12
申请号：US15819500
申请日：2017-11-21
Applicant: VIB VZW , Vrije Universiteit Brussel , The Board of Trustees of the Leland Stanford Junior University
Inventor： Jan Steyaert , Els Pardon , Soren G.F. Rasmussen , Juan Jose Fung , Brian Kobilka , Toon Laeremans
CPC classification number: G01N33/6872 , A61K38/00 , C07K14/705 , C07K14/723 , C07K16/28 , C07K2317/22 , C07K2317/33 , C07K2317/51 , C07K2317/56 , C07K2317/569 , C07K2317/75 , G01N23/20 , G01N33/566 , G01N33/68 , G01N33/6857 , G01N2333/726
Abstract: The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that are capable of increasing the stability of a functional conformational state of a GPCR, in particular, increasing the stability of a GPCR in its active conformational state. The protein binding domains of the present invention can be used as a tool for the structural and functional characterization of G-protein-coupled receptors bound to various natural and synthetic ligands, as well as for screening and drug discovery efforts targeting GPCRs. Moreover, the invention also encompasses the diagnostic, prognostic and therapeutic usefulness of these protein binding domains for GPCR-related diseases.
-
公开(公告)号：US12237432B2
公开(公告)日：2025-02-25
申请号：US18244767
申请日：2023-09-11
Inventor： Austin Flick , Reinhold H. Dauskardt
IPC: H01L31/0463 , B23K26/06 , B23K26/0622 , B23K26/40 , H01L31/0224 , H01L31/05 , B23K103/16
Abstract: A vertically selective liftoff scribing process is provided. One application is the fabrication of solar cells and solar modules. The basis of this technology is absorption of an indirectly focused laser beam in the front electrode material of the device, which enables removal of this layer (e.g., a P1 scribe) or removal of layers above the front electrode while leaving the front electrode intact (e.g., a P2 or P3 scribe). The laser fluence can be selected to choose between these alternatives, and further fine tuning is possible depending on details of the device structure.
-
公开(公告)号：US20250062642A1
公开(公告)日：2025-02-20
申请号：US18610992
申请日：2024-03-20
Inventor： Daniel Michael Pivonka , Anatoly Anatolievich Yakovlev , Ada Shuk Yan Poon , Teresa H. Meng
IPC: H02J50/10 , A61B1/00 , A61B5/07 , A61M25/01 , A61M31/00 , H02J7/34 , H02J50/23 , H02J50/27 , H02J50/80 , H02J50/90
Abstract: Described is a locomotive implant for usage within a predetermined magnetic field. In one embodiment magnetohydrodynamics is used to generate thrust with a plurality of electrodes. In another embodiment, asymmetric drag forces are used to generate thrust.
-
Patent Agency Ranking
公开(公告)号：US12227553B2
公开(公告)日：2025-02-18
申请号：US18187639
申请日：2023-03-21
Applicant: UNIVERSITY OF WASHINGTON , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventor： Daniel Adriano Silva Manzano , Shawn Yu , Umut Ulge , David Baker , Kenan Christopher Garcia , Jamie Spangler , Carl Walkey
Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγc heterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.
-
公开(公告)号：US12226892B2
公开(公告)日：2025-02-18
申请号：US18022208
申请日：2021-09-07
Inventor： Margot R. Vulliez , Oussama Khatib
Abstract: A versatile, compact, and high-fidelity haptic device is provided. The mechanical transparency of the design and the selection of proper actuation meet the challenges of an accurate and stiff haptic device with high and isotropic force capability. Such a haptic interface enables a precise remote control and provides perfect sense of the task interaction in any environments and applications.
-
公开(公告)号：US20250050075A1
公开(公告)日：2025-02-13
申请号：US18233204
申请日：2023-08-11
Inventor： Kunj Raju Sheth , James K. Wall , Yair Blumenfeld , Eric Johnson , Enrico Danzer
Abstract: A medical device includes: an elongated member having a first end, a second end, and a body extending between the first end and the second end; a first anchor coupled to the first end of the elongated member; and a second anchor coupled to the second end of the elongated member; wherein the elongated member is configured for placement across an abdominal wall of a fetus, and wherein the elongated member is elastically stretchable to accommodate for a growing thickness of the abdominal wall of the fetus.
-
公开(公告)号：US20250049884A1
公开(公告)日：2025-02-13
申请号：US18719766
申请日：2023-01-03
Inventor： Francis Gerard Blankenberg , Derek R. Holman
IPC: A61K38/17
Abstract: Transcriptomic changes induced by uptake of extracellular vesicles (EVs) are blocked or reversed by administration of an effective dose of Annexin V protein (AnxV), e.g. by administration of AnxV to a tumor microenvironment (TME). In some embodiments, administration of AnxV is combined with a second anti-cancer therapy. In some embodiments, cells present in the TME are evaluated for transcriptional changes associated with EV uptake following administration of the effective dose of AnxV.
-
公开(公告)号：US20250041487A1
公开(公告)日：2025-02-06
申请号：US18717323
申请日：2022-12-09
Inventor： Yunzhi Yang , Seyedsina Moeinzadeh
Abstract: Tissue engineering constructs and the method of making the constructs are provided. The constructs distinguish a scaffold with a surface and a treated surface area for increased surface area. A hydrophilic hydrogel network is physically cross-linked via charged polymers and salt-ions onto the treated surface area. Biologies is trapped and thereby hosted within the physically cross-linked hydrogel network. Covalently reactive macromonomers are chemically cross-linked within the physically cross-linked hydrophilic hydrogel network to strengthen the physically cross-linked hydrophilic hydrogel network itself and to the scaffold. The constructs enable delivery of therapeutics including cells and/or biomolecules along with a structural support and a defined geometry for applications in regenerative medicine.
-
-
-
-
-
-
-
-
-
Search Results
6551
records
(took 0.283 seconds)
