公开(公告)号：US12238849B2

公开(公告)日：2025-02-25

申请号：US18026245

申请日：2021-04-26

Applicant: SHIMADZU CORPORATION

Inventor： Masaji Furuta

IPC: H05H1/30 ,  G01N27/623 ,  H01J49/26

Abstract: A radical generation device includes: a cylindrical tube; an antenna; an outer conductor part; and a connection part which has a double cylindrical tube structure including an inner cylindrical body and an outer cylindrical body, end portions of the inner cylindrical body and the outer cylindrical body on the same side are divided in a circumferential direction notches extending in an axial direction to form divided pieces, and tapered portions swelling outward toward a tip end are formed on an outer side of the divided pieces or tapered portions swelling inward toward a tip end are formed on an inner side of the divided pieces.

公开(公告)号：US12235196B2

公开(公告)日：2025-02-25

申请号：US17264887

申请日：2018-09-18

Applicant: SHIMADZU CORPORATION

Inventor： Toshiya Matsubara

IPC: G01N1/38 ,  G01N33/68

Abstract: The present invention provides a method for pretreatment of a biological sample in order to measure a protein contained in the biological sample by liquid chromatography/mass spectrometry. The method includes the step of adding an acetic acid aqueous solution to the biological sample, so as to prepare a pretreatment sample containing an acetic acid at a concentration ranging from 20 to 50 weight percent, both inclusive. In the present invention, a target protein contained in a biological sample is less prone to be adsorbed to a sample container, thereby resulting in an increased sensitivity of measuring the protein in the biological sample by mass spectrometry. Further, reproducibility of results of the mass spectrometry is improved, and reliability is increased.

公开(公告)号：US20250057456A1

公开(公告)日：2025-02-20

申请号：US18723353

申请日：2022-10-28

Applicant: SHIMADZU CORPORATION

Inventor： Kei SHINADA

IPC: A61B5/242 ,  A61B5/00

Abstract: Provided are a biomagnetic measuring device and a control method for a biomagnetic measuring device that can measure biomagnetism more accurately. A biomagnetic measuring device according to the present invention includes: a first magnetic sensor and a second magnetic sensor that each include a cell having an internal space, and detect biomagnetism utilizing an optical pumping action by plasma generated in the cell; a plasma generator that supplies electric power for generating plasma in the internal space of each of the cells included in the first magnetic sensor and the second magnetic sensor; and a power supply controller that controls the plasma generator to generate plasma in the first magnetic sensor from a first start time to a first end time and generate plasma in the second magnetic sensor from a second start time after the first start time to a second end time after the first end time.

公开(公告)号：US20250052613A1

公开(公告)日：2025-02-13

申请号：US18718017

申请日：2022-06-03

Applicant: SHIMADZU CORPORATION

Inventor： Takahiro TAMAKI

IPC: G01J3/30 ,  G01J3/02 ,  G01J3/10 ,  G01J3/42

Abstract: A spectrophotometer includes: a light source configured to emit light in a wavelength band including an excitation wavelength which causes a photoreaction on a target substance in a sample, the light source emitting a known number of photons of the light having the excitation wavelength; an integrating sphere having a light entrance port through which light emitted from the light source enters and a light emission port provided at a position deviated from an optical axis of the light entering the light entrance port; a sample placement unit provided in the light entrance port; and a light intensity measurement unit configured to measure intensity of light having the excitation wavelength emitted from the light emission port.

公开(公告)号：US12222336B2

公开(公告)日：2025-02-11

申请号：US17641679

申请日：2020-11-18

Applicant: SHIMADZU CORPORATION

Inventor： Akira Aono ,  Shota Hata ,  Naru Maruoka ,  Hideki Sato

IPC: G01N30/20 ,  G01N30/26 ,  G01N30/88

Abstract: A switching mechanism 110 can perform switching to a pressurized state in which gas is supplied from a pipe 203 to an insertion tube 101, or a derivation state in which gas in a head space 23 that is pressurized is derived from the insertion tube 101 to the pipe 207 via a collection unit 104. The switching mechanism 110 includes a discharge valve 103 that puts the insertion tube 101 and the pipe 207 into a non-communication state in the pressurized state and puts the insertion tube 101 and the pipe 207 into a communication state in the derivation state. A resistance pipe 206 supplies gas to a channel between the collection unit 104 and the discharge valve 103 in the derivation state.

公开(公告)号：US20250044262A1

公开(公告)日：2025-02-06

申请号：US18784777

申请日：2024-07-25

Applicant: SHIMADZU CORPORATION

Inventor： Masato WATANABE

IPC: G01N30/66 ,  G01N30/02 ,  G01N30/30 ,  G01N30/62

Abstract: A lamp house (6), a lamp (8) including a light emitting part (16) that emits light and a base end portion (18) from which a lead wire from the light emitting part (16) is drawn out, the lamp (8) being attached to the lamp house (6) in a state where the light emitting part (16) is accommodated in the lamp house (6) and the base end portion (18) is exposed to the outside of the lamp house (6), a housing (2) having an internal space and a ventilation port (24, 32) for taking air into the internal space from outside of the internal space and exhausting the air from the internal space, and accommodating the lamp house (6) in the internal space in a manner that the lamp house (6) and the base end portion (18) of the lamp (8) are located on a flow path of the air flowing through the internal space, a fan (12, 12′) provided so as to form a flow of the air in the internal space of the housing (2), and a heater (10, 10′) for heating the air taken into the internal space of the housing (2) are included. The base end portion (18) of the lamp (8) and the lead wire (20) are heated by receiving the air heated by the heater (10, 10′).

公开(公告)号：US12216113B2

公开(公告)日：2025-02-04

申请号：US17073608

申请日：2020-10-19

Applicant: SHIMADZU CORPORATION

Inventor： Takashi Nishikaze ,  Hisatoshi Hanamatsu ,  Jun-ichi Furukawa ,  Ikuko Yokota

IPC: G01N33/50 ,  C07H1/00

Abstract: A method for preparing an analysis sample from a sample containing a glycan, includes: performing esterification reaction that subjects at least a part of a sialic acid included in the glycan to esterification other than lactonization; and performing amidation reaction that converts an esterified form of a sialic acid modified through the esterification into an amidated form through contacting the sample with an amidation reaction solution containing at least one compound selected from the group consisting of ammonia, amines, hydrazine, hydrazine derivatives, and hydroxyamine, and salts thereof to be reacted with the sialic acid modified through the esterification.

公开(公告)号：US20250035925A1

公开(公告)日：2025-01-30

申请号：US18764419

申请日：2024-07-05

Applicant: SHIMADZU CORPORATION

Inventor： Masato TANAKA

IPC: G02B27/01 ,  G02B27/09

Abstract: A head-up display device that projects display light onto a windshield of a manned vehicle and directs the display light reflected by the windshield toward the observer's eyes to form a virtual image in front of the observer's eyes, includes: an image emitting unit for forming parallel light beams different in angle at each location on the image and emit the light beams as display light; a light guide for emitting the light beams as the display light by expanding the light beams while maintaining the parallelism thereof; and a correcting lens arranged on an optical path between the light guide and the windshield. The correcting lens has a curved surface shape that deflects a light transmission direction according to a curved surface shape of a reflective surface of the windshield so that the display light becomes parallel after being reflected by the windshield.

公开(公告)号：US20250031293A1

公开(公告)日：2025-01-23

申请号：US18774734

申请日：2024-07-16

Applicant: SHIMADZU CORPORATION

Inventor： Yohei UKAI

IPC: H05G1/10 ,  G01N23/223

Abstract: An X-ray fluorescence analyzer is provided with an X-ray tube that irradiates primary X-rays, a first power supply that supplies a filament current, a second power supply that applies a tube voltage, a first diode connected to a power line, a Zener diode connected to the ground terminal, and an operational amplifier having an inverting input terminal, and a non-inverting input terminal. The non-inverting input terminal is connected to the power line, and the output terminal is connected to the second terminal and the inverting input terminal.

公开(公告)号：US20250026669A1

公开(公告)日：2025-01-23

申请号：US18715396

申请日：2022-10-26

Applicant: SHIMADZU CORPORATION

Inventor： Yoshio IKEZAWA

IPC: C02F1/40 ,  B01D21/24 ,  B01D21/30 ,  C02F1/00 ,  C02F1/68 ,  C02F101/30 ,  C02F103/08

Abstract: In a container, a sample is separated with a heavy solution based on a specific gravity. An overflow pipe is a pipe provided at an upper portion of the container, the overflow pipe being arranged to cause a supernatant containing a target substance separated by gravity separation in the container to overflow from the upper portion of the container. A control device controls entry and exit of the heavy solution into and from the container. The control device causes some of the supernatant produced by gravity separation to flow over the container through the overflow pipe, thereafter causes the supernatant that remains in the overflow pipe to flow back into the container, and then causes the supernatant to flow over again through the overflow pipe.