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    MULTIPLEX COLON CANCER MARKER PANEL
    2.
    发明申请
    MULTIPLEX COLON CANCER MARKER PANEL 审中-公开
    多功能殖民地癌症标志物面板

    公开(公告)号：US20130165340A1

    公开(公告)日：2013-06-27

    申请号：US13723133

    申请日：2012-12-20

    Applicant: SHIMADZU CORPORATION ,  OSAKA UNIVERSITY

    Inventor： Makoto Watanabe ,  Eiichi Matsuo ,  Naoki Kaneko ,  Toshiya Matsubara ,  Osamu Nishimura ,  Masaki Mori ,  Hideo Matsuda ,  Shigeto Seno ,  Ichiro Takemasa

    IPC: G01N33/68

    CPC classification number: G01N33/57419 ,  G01N33/6893

    Abstract: The present invention provides a specific combination of colon cancer markers based on statistical knowledge, which is capable of detecting a larger number of colon cancer patients in an earlier stage while maintaining high specificity. A multiplex colon cancer marker panel comprising a combination of five colon cancer markers of Carcinoembryonic antigen-related cell adhesion molecule 5, Carbohydrate antigen 19-9, Galectin-4, APEX nuclease and Actin-related protein 2.A method for analyzing colon cancer markers using multiplex colon cancer marker panel.

    Abstract translation: 本发明提供了基于统计知识的结肠癌标志物的特异性组合，其能够在保持高特异性的同时检测较早数量的结肠癌患者。 包括癌胚抗原相关细胞粘附分子5，碳水化合物抗原19-9，半乳凝素-4，APEX核酸酶和肌动蛋白相关蛋白2的五个结肠癌标志物的组合的多重结肠癌标志物。2.一种分析结肠癌标志物的方法 使用多重结肠癌标记物。

    Method for pretreatment of biological sample
    4.
    发明授权
    Method for pretreatment of biological sample 有权

    公开(公告)号：US12235196B2

    公开(公告)日：2025-02-25

    申请号：US17264887

    申请日：2018-09-18

    Applicant: SHIMADZU CORPORATION

    Inventor： Toshiya Matsubara

    IPC: G01N1/38 ,  G01N33/68

    Abstract: The present invention provides a method for pretreatment of a biological sample in order to measure a protein contained in the biological sample by liquid chromatography/mass spectrometry. The method includes the step of adding an acetic acid aqueous solution to the biological sample, so as to prepare a pretreatment sample containing an acetic acid at a concentration ranging from 20 to 50 weight percent, both inclusive. In the present invention, a target protein contained in a biological sample is less prone to be adsorbed to a sample container, thereby resulting in an increased sensitivity of measuring the protein in the biological sample by mass spectrometry. Further, reproducibility of results of the mass spectrometry is improved, and reliability is increased.

    Chromatograph mass spectrometer
    5.
    发明授权
    Chromatograph mass spectrometer 有权

    公开(公告)号：US11531012B2

    公开(公告)日：2022-12-20

    申请号：US17479073

    申请日：2021-09-20

    Applicant: SHIMADZU CORPORATION

    Inventor： Kazuma Maeda ,  Toshiya Matsubara

    IPC: H01J49/00 ,  G01N30/72 ,  G01N30/86

    Abstract: In a chromatograph mass spectrometer having a measurement unit (1) including a chromatograph is combined with a tandem mass spectrometry section capable of an MS/MS analysis, a controller (40) performs chromatograph mass spectrometry by controlling the measurement unit so as to operate the tandem mass spectrometry section to cyclically perform analysis cycles, where each of the analysis cycles includes a first mass spectrometric analysis in which a measurement of ions is performed over a predetermined m/z range and an MS/MS analysis by DIA in which ions included within each of a plurality of windows formed by dividing the m/z range are designated as a precursor ion. A window selector (42, 43) selects, during an execution of an analysis cycle, a window among the plurality of windows for an MS/MS analysis by DDA which is irregularly performed in an ongoing analysis cycle, based on intensity information obtained for each of the plurality of windows from an MS/MS spectrum acquired by the MS/MS analysis by DIA. A precursor-ion determiner (44) determines a precursor ion corresponding to the window selected by the window selector in a mass spectrum acquired by the first mass spectrometric analysis in the ongoing analysis cycle, based on peak information included within the m/z range of the window. A data-dependent-acquisition condition setter (45) informs the controller of the precursor ion determined by the precursor-ion determiner, as the precursor ion for the MS/MS analysis by DDA which is irregularly performed in the ongoing analysis cycle.

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