公开(公告)号：US07371374B2

公开(公告)日：2008-05-13

申请号：US11178216

申请日：2005-07-08

申请人： John Sinden ,  Jeffrey A. Gray ,  Helen Hodges ,  Timothy Kershaw ,  Fiza Rashid-Doubell

发明人： John Sinden ,  Jeffrey A. Gray ,  Helen Hodges ,  Timothy Kershaw ,  Fiza Rashid-Doubell

IPC分类号： A01N63/00 ,  A61K48/00

CPC分类号： A61K35/30 ,  A61K35/12 ,  C12N5/0623 ,  C12N2500/25 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2501/24 ,  C12N2501/392 ,  C12N2501/395 ,  C12N2501/91

摘要： The subject invention pertains to a novel method of correction of behavioral and/or psychological deficits made possible by the intracerebral transplantation of pluripotent neuroepithelial cells. Cells, cell lines, pharmaceutical preparations, medicaments, methods for the production and maintenance of the cell lines for use in the method of the invention are encompassed by the invention.

摘要翻译： 本发明涉及通过脑内移植多能神经上皮细胞使行为和/或心理缺陷的校正的新方法。 本发明包括细胞，细胞系，药物制剂，药物，用于生产和维持用于本发明方法的细胞系的方法。

公开(公告)号：US07247298B2

公开(公告)日：2007-07-24

申请号：US10342692

申请日：2003-01-14

申请人： Helen Hodges

发明人： Helen Hodges

IPC分类号： A61K48/00 ,  A01N63/00

CPC分类号： A61F2/022

摘要： The present invention relates to the treatment of brain damage by cellular transplantation. According to one aspect of the invention, a method for treating a motor, sensory and/or cognitive deficit comprises administering a composition comprising pluripotent cells into the damaged brain in a region contra-lateral to that containing the site of damage. The cells are preferably conditionally immortal.

摘要翻译： 本发明涉及通过细胞移植治疗脑损伤。 根据本发明的一个方面，一种用于治疗运动，感觉和/或认知缺陷的方法包括将包含多能细胞的组合物在与含有损伤部位的区域相反的区域中施用于受损脑中。 细胞优选是有条件的不朽的。

公开(公告)号：US20230220344A1

公开(公告)日：2023-07-13

申请号：US17996329

申请日：2021-04-15

申请人： ReNeuron Limited

发明人： Steve PELLS ,  Marcela ROSAS ,  Randolph CORTELING

IPC分类号： C12N5/0789 ,  C12N5/0783 ,  C12N15/90

CPC分类号： C12N5/0647 ,  C12N5/0636 ,  C12N15/907 ,  C12N2510/04 ,  C12N2506/45 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604

摘要： The invention relates to induced pluripotent stem cells that are generated from cells, for example Adult Stem Cells, that are conditionally-immortalisable. In particular, the invention relates to induced pluripotent stem cells generated from stem cell lines comprising a controllable transgene for conditional immortalisation, and the progeny of those induced pluripotent stem cells such as cells of the haematopoietic lineage. Induced pluripotent stem cells, haematopoietic progeny cells derived from those pluripotent cells, compositions comprising those cells, methods of making all of those cells, and uses of all of those cells are also described.

公开(公告)号：US09629879B2

公开(公告)日：2017-04-25

申请号：US13701932

申请日：2011-07-11

申请人： Randolph Corteling ,  Caroline Hicks ,  John Sinden ,  Jack Price

发明人： Randolph Corteling ,  Caroline Hicks ,  John Sinden ,  Jack Price

IPC分类号： A61K35/30 ,  C12N5/0797 ,  A61K35/12

CPC分类号： A61K35/30 ,  A61K2035/122 ,  C12N5/0623

摘要： The present invention provides an isolated cell obtainable from the CTX0E03 neural stem cell line for use in the treatment of a disorder associated with elevated levels of pro-inflammatory cytokines, wherein the disorder is selected from unipolar and bipolar depression, schizophrenia, obsessive compulsive disorder, autism and autistic syndrome disorders.

公开(公告)号：US07419827B2

公开(公告)日：2008-09-02

申请号：US11283621

申请日：2005-11-21

申请人： John Sinden ,  Kenneth Pollock ,  Paul Stroemer

发明人： John Sinden ,  Kenneth Pollock ,  Paul Stroemer

IPC分类号： C12N5/08 ,  C12N5/00 ,  C12N5/10 ,  A61K48/00 ,  A01N63/00

CPC分类号： C12N5/0623 ,  A61K35/12 ,  C12N2500/25 ,  C12N2500/46 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/392 ,  C12N2510/04

摘要： Genomic instability in T-antigen expressing cells can be overcome by modifying the gene expressing T-antigen so that it lacks Bub1 binding. Stable cell lines can be produced by incorporation of the modified T-antigen gene, preferably together with the catalytic sub-unit of the telomerase construct.

摘要翻译： 可以通过修饰表达T抗原的基因使其缺少Bub1结合来克服T抗原表达细胞中的基因组不稳定性。 可以通过掺入修饰的T抗原基因，优选与端粒酶构建体的催化亚单位一起产生稳定的细胞系。

公开(公告)号：US07048921B2

公开(公告)日：2006-05-23

申请号：US09760274

申请日：2001-01-12

申请人： John Sinden ,  Jeffrey A. Gray ,  Helen Hodges ,  Timothy Kershaw ,  Fiza Rashid-Doubell

发明人： John Sinden ,  Jeffrey A. Gray ,  Helen Hodges ,  Timothy Kershaw ,  Fiza Rashid-Doubell

IPC分类号： A61K35/00 ,  C12N15/63

CPC分类号： A61K35/30 ,  A61K35/12 ,  C12N5/0623 ,  C12N2500/25 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2501/24 ,  C12N2501/392 ,  C12N2501/395 ,  C12N2501/91

摘要： The subject invention pertains to a novel method of correction of behavioral and/or psychological deficits made possible by the intracerebral transplantation of pluripotent neuroepithelial cells. Cells, cell lines, pharmaceutical preparations, medicaments, methods for the production and maintenance of the cell lines for use in the method of the invention are encompassed by the invention.

公开(公告)号：US20120093786A1

公开(公告)日：2012-04-19

申请号：US13141453

申请日：2010-02-05

申请人： John Sinden ,  Erik Miljan ,  Paolo Madeddu

发明人： John Sinden ,  Erik Miljan ,  Paolo Madeddu

IPC分类号： A61K35/30 ,  A61P9/10 ,  A61P9/00

CPC分类号： C12N5/0623 ,  A61K35/12 ,  A61K35/30 ,  C12N2510/04

摘要： The present invention uses neural stem cells in the manufacture of a medicament for the treatment of a patient suffering peripheral arterial disease. The invention is particularly suited for treating limb ischemia or Buerger's disease.

摘要翻译： 本发明在制造用于治疗患有外周动脉疾病的患者的药物中使用神经干细胞。 本发明特别适用于治疗肢体缺血或Buerger病。

公开(公告)号：US07416888B2

公开(公告)日：2008-08-26

申请号：US11238702

申请日：2005-09-29

申请人： John Sinden ,  Kenneth Pollock ,  Paul Stroemer

发明人： John Sinden ,  Kenneth Pollock ,  Paul Stroemer

IPC分类号： C12N5/08 ,  C12N5/00 ,  C12N5/10 ,  A61K48/00 ,  A01N63/00

CPC分类号： C12N5/0623 ,  A61K35/12 ,  C12N2500/25 ,  C12N2500/46 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/392 ,  C12N2510/04

摘要： The present invention relates to cells obtainable from cell lines having the ECACC Accession Nos 04091601, 04110301 and 04092302.

摘要翻译： 本发明涉及可从具有ECACC登录号04091601,04110301和04092302的细胞系获得的细胞。

公开(公告)号：US20230227854A1

公开(公告)日：2023-07-20

申请号：US17633570

申请日：2020-08-10

申请人： ReNeuron Limited

发明人： Randolph CORTELING ,  Ruben DEOGRACIAS

IPC分类号： C12N15/90 ,  C12N5/079 ,  C12N5/0783 ,  C12N5/0797 ,  A61K35/12 ,  A61K48/00

CPC分类号： C12N15/907 ,  C12N5/0622 ,  C12N5/0636 ,  C12N5/0623 ,  A61K35/12 ,  A61K48/005 ,  C12N2510/00

摘要： This invention relates to genetic engineering, in particular to an insertion site for a transgene, cells comprising a transgene or other modification at that insertion site, vectors for targeting that insertion site, and methods for creating transgenic cells by insertion or other modification at that site. The insertion site, or “safe harbour locus”, is identified within the SPATA13 gene on human chromosome 13q12.12. Mammalian cells comprising a genetic modification within the SPATA13 gene on chromosome 13q12.12 are described, wherein the modification may be an insertion such as an integrated transgene. Nucleic acid molecules able and adapted to guide the insertion of a transgene to that insertion site are also described. These cells or nucleic acids may be useful in therapy.

公开(公告)号：US20210371828A1

公开(公告)日：2021-12-02

申请号：US17284428

申请日：2019-10-11

申请人： ReNeuron Limited

发明人： Steve PELLS ,  Randolph CORTELING ,  John Sinden

IPC分类号： C12N5/074 ,  A61K35/545

摘要： The invention relates to induced pluripotent stem cells that are generated from cells, for example Adult Stem Cells, that are conditionally-immortalisable. In particular, the invention relates to induced pluripotent stem cells generated from stem cell lines comprising a controllable transgene for conditional immortalisation, and the progeny of those induced pluripotent stem cells. Induced pluripotent stem cells, progeny cells derived from those pluripotent cells, compositions comprising those cells, methods of making all of those cells, and uses of all of those cells are also described.