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1.发明申请METHODS AND COMPOSITIONS FOR ORAL ADMINISTRATION OF PROTEIN AND PEPTIDE THERAPEUTIC AGENTS 有权蛋白质和肽治疗药物口服给药的方法和组合公开(公告)号：US20100297245A1
公开(公告)日：2010-11-25
申请号：US12811871
申请日：2009-01-08
申请人： Alexander Vol , Orna Gribova
发明人： Alexander Vol , Orna Gribova
IPC分类号： A61K9/14 , A61K38/18 , A61K38/27 , A61K39/395 , A61K38/23 , A61K38/19 , A61K38/21 , A61K38/46 , A61P17/18 , A61P35/00
CPC分类号： A61K9/0053 , A61K9/10 , A61K9/4891 , A61K38/16 , A61K38/17 , A61K38/1816 , A61K38/1841 , A61K38/191 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/363 , A61K38/39 , A61K38/465 , A61K39/3955 , A61K47/02 , A61K47/36 , A61K47/44
摘要： The present invention provides a pharmaceutical composition formulated for oral delivery, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and a biologically active protein or peptide suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of a therapeutic protein or peptide.
摘要翻译： 本发明提供配制用于口服递送的药物组合物，其包含具有疏水表面，多糖和悬浮在油中的生物活性蛋白质或肽的药理惰性二氧化硅纳米颗粒的非共价相关混合物。 本发明进一步提供了用于口服递送治疗性蛋白质或肽的相同方法和利用其的治疗方法。
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公开(公告)号：US09504648B2
公开(公告)日：2016-11-29
申请号：US14715585
申请日：2015-05-18
发明人： Alexander Vol , Orna Gribova
CPC分类号： A61K9/006 , A61K9/0019 , A61K9/0095 , A61K9/10 , A61K9/107 , A61K47/02 , A61K47/26 , Y02A50/395
摘要： Provided is a matrix carrier composition for use in pharmaceutical delivery system, the composition comprising an intermolecular association of at least a first solid phase comprising nanoparticles having hydrophobic surface, wherein the size of the nanoparticles is in the range of about 5-1000 nm, a second solid phase, comprising a biopolymer having hydrophilic and hydrophobic parts, and a continuous phase comprising oil associated with the first and said second solid phases.
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公开(公告)号：US09060932B2
公开(公告)日：2015-06-23
申请号：US13381225
申请日：2010-07-08
申请人： Alexander Vol , Orna Gribova
发明人： Alexander Vol , Orna Gribova
CPC分类号： A61K9/006 , A61K9/0019 , A61K9/0095 , A61K9/10 , A61K9/107 , A61K47/02 , A61K47/26 , Y02A50/395
摘要： Provided is a matrix carrier composition for use in pharmaceutical delivery system, the composition comprising an intermolecular association of at least a first solid phase comprising nanoparticles having hydrophobic surface, wherein the size of the nanoparticles is in the range of about 5-1000 nm, a second solid phase, comprising a biopolymer having hydrophilic and hydrophobic parts, and a continuous phase comprising oil associated with the first and said second solid phases.
摘要翻译： 提供一种用于药物递送系统的基质载体组合物，该组合物包含至少包含具有疏水表面的纳米颗粒的至少第一固相的分子间缔合，其中纳米颗粒的尺寸在约5-1000nm范围内， 第二固相，包含具有亲水和疏水部分的生物聚合物，以及包含与第一和第二固相相关的油的连续相。
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4.发明授权公开(公告)号：US09949924B2
公开(公告)日：2018-04-24
申请号：US14565416
申请日：2014-12-09
发明人： Alexander Vol , Orna Gribova
IPC分类号： A61K9/00 , A61K9/10 , A61K9/48 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/36 , A61K38/39 , A61K38/16 , A61K38/17 , A61K38/28 , A61K38/46 , A61K39/395 , A61K47/02 , A61K47/36 , A61K47/44
CPC分类号： A61K9/0053 , A61K9/10 , A61K9/4891 , A61K38/16 , A61K38/17 , A61K38/1816 , A61K38/1841 , A61K38/191 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/363 , A61K38/39 , A61K38/465 , A61K39/3955 , A61K47/02 , A61K47/36 , A61K47/44
摘要： The present invention provides a pharmaceutical composition formulated for oral delivery, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and a biologically active protein or peptide suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of a therapeutic protein or peptide.
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5.发明授权Methods and compositions for oral administration of protein and peptide therapeutic agents 有权用于口服给予蛋白质和肽治疗剂的方法和组合物公开(公告)号：US08936786B2
公开(公告)日：2015-01-20
申请号：US12811871
申请日：2009-01-08
申请人： Alexander Vol , Orna Gribova
发明人： Alexander Vol , Orna Gribova
IPC分类号： A61K39/44 , A61K38/39 , A61K9/10 , A61K9/48 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/36 , A61K39/00
CPC分类号： A61K9/0053 , A61K9/10 , A61K9/4891 , A61K38/16 , A61K38/17 , A61K38/1816 , A61K38/1841 , A61K38/191 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/363 , A61K38/39 , A61K38/465 , A61K39/3955 , A61K47/02 , A61K47/36 , A61K47/44
摘要： The present invention provides a pharmaceutical composition formulated for oral delivery, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and a biologically active protein or peptide suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of a therapeutic protein or peptide.
摘要翻译： 本发明提供配制用于口服递送的药物组合物，其包含具有疏水表面，多糖和悬浮在油中的生物活性蛋白质或肽的药理惰性二氧化硅纳米颗粒的非共价相关混合物。 本发明进一步提供了用于口服递送治疗性蛋白质或肽的相同方法和利用其的治疗方法。
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公开(公告)号：US20120100216A1
公开(公告)日：2012-04-26
申请号：US13381225
申请日：2010-07-08
申请人： Alexander Vol , Orna Gribova
发明人： Alexander Vol , Orna Gribova
CPC分类号： A61K9/006 , A61K9/0019 , A61K9/0095 , A61K9/10 , A61K9/107 , A61K47/02 , A61K47/26 , Y02A50/395
摘要： Provided is a matrix carrier composition for use in pharmaceutical delivery system, the composition comprising an intermolecular association of at least a first solid phase comprising nanoparticles having hydrophobic surface, wherein the size of the nanoparticles is in the range of about 5-1000 nm, a second solid phase, comprising a biopolymer having hydrophilic and hydrophobic parts, and a continuous phase comprising oil associated with the first and said second solid phases.
摘要翻译： 提供一种用于药物递送系统的基质载体组合物，该组合物包含至少包含具有疏水表面的纳米颗粒的至少第一固相的分子间缔合，其中纳米颗粒的尺寸在约5-1000nm范围内， 第二固相，包含具有亲水和疏水部分的生物聚合物，以及包含与第一和第二固相相关的油的连续相。
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公开(公告)号：US20100278922A1
公开(公告)日：2010-11-04
申请号：US12811859
申请日：2009-01-08
申请人： Alexander Vol , Orna Gribova
发明人： Alexander Vol , Orna Gribova
CPC分类号： A61K9/0053 , A61K9/10 , A61K9/4891 , A61K38/16 , A61K38/17 , A61K38/1816 , A61K38/1841 , A61K38/191 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/363 , A61K38/39 , A61K38/465 , A61K39/3955 , A61K47/02 , A61K47/36 , A61K47/44
摘要： The present invention provides a pharmaceutical composition formulated for oral delivery of insulin, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and insulin suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of insulin.
摘要翻译： 本发明提供配制用于口服胰岛素的药物组合物，其包含具有疏水表面，多糖和悬浮在油中的胰岛素的药理惰性二氧化硅纳米粒子的非共价相关混合物颗粒。 本发明进一步提供了制备相同的方法和利用该方法口服胰岛素的治疗方法。
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