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公开(公告)号：US20240301500A1
公开(公告)日：2024-09-12
申请号：US18277554
申请日：2022-02-24
IPC分类号： C12Q1/6886 , C12Q1/6874
CPC分类号： C12Q1/6886 , C12Q1/6874 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156
摘要： Provided herein are methods for assessing a risk of a trait in a subject, by selecting a plurality of ancestry-informative SNP markers based on objective design criteria, measuring a genotype of the subject, obtaining trait-associated SNP markers, and calculating a global polygenic risk score for the risk of the trait in the subject based on the plurality of ancestry-informative SNP markers and the trait-associated SNP markers. The trait can be risk of cancer. Also provided are methods for assessing ancestry of a subject.
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公开(公告)号：US20230260658A1
公开(公告)日：2023-08-17
申请号：US17920013
申请日：2021-04-16
发明人： Dmitry Pruss , Alexander Gutin , Elisha Hughes , Jerry Lanchbury
摘要： Provided herein are methods for determining polygenic traits and risks for medical use, such as cancer traits and risks, as well as treating diseases for which risk is identified and/or assessed. Methods of this invention can provide a polygenic score which takes into account local ancestry through the ancestral origin of the alleles of risk loci. A polygenic score can provide surprisingly increased accuracy in determining polygenic traits and risks for ancestrally admixed populations.
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公开(公告)号：US20230170045A1
公开(公告)日：2023-06-01
申请号：US17920012
申请日：2021-04-16
IPC分类号： G16B20/20 , C12Q1/6886 , G16H50/30
CPC分类号： G16B20/20 , C12Q1/6886 , G16H50/30 , C12Q2600/156
摘要： Provided herein are methods for determining a polygenic risk score and breast cancer estimated risk for medical use, as well as for treating breast cancer. Methods of this invention can provide a polygenic risk score which takes into account a plurality of breast cancer associated SNP markers. Also provide is a comprehensive breast cancer risk estimation with increased accuracy.
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公开(公告)号：US20230111438A1
公开(公告)日：2023-04-13
申请号：US18081586
申请日：2022-12-14
IPC分类号： C12Q1/6886 , G16B20/20 , G16B20/10 , A61K33/243 , A61K31/282
摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
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公开(公告)号：US20230094830A1
公开(公告)日：2023-03-30
申请号：US18072520
申请日：2022-11-30
发明人： Susanne WAGNER
IPC分类号： G01N33/574 , G16B30/00 , C12Q1/6886 , G16H50/30 , G16H50/20 , G01N33/573
摘要： This disclosure generally relates to a molecular classification of cancer and particularly to molecular markers for predicting response to cancer therapy, including cancer immune therapy, and methods of use thereof.
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公开(公告)号：US20220205046A1
公开(公告)日：2022-06-30
申请号：US17499284
申请日：2021-10-12
IPC分类号： C12Q1/6886 , C12Q1/6827 , G16B20/00 , G16H20/00 , G16B20/20 , G16B20/10
摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
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公开(公告)号：US11174519B2
公开(公告)日：2021-11-16
申请号：US16691480
申请日：2019-11-21
IPC分类号： C12Q1/6886 , C12Q1/6827 , G16B20/00 , G16H20/00 , G16B20/20 , G16B20/10
摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
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公开(公告)号：US11104956B2
公开(公告)日：2021-08-31
申请号：US14561938
申请日：2014-12-05
发明人： Kirsten Timms , Brian Allen , Anne-Renee Hartman
IPC分类号： C12P19/34 , C12Q1/6886 , G01N33/574 , G16B20/00 , A61K31/138 , G16B30/00
摘要： The invention generally relates to a molecular classification of disease predisposition and particularly to molecular markers for cancer predisposition and methods of use thereof.
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公开(公告)号：US10851425B2
公开(公告)日：2020-12-01
申请号：US16576643
申请日：2019-09-19
IPC分类号： C12Q1/6886 , C12Q1/6827 , G16B20/00
摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
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公开(公告)号：US20200056246A1
公开(公告)日：2020-02-20
申请号：US16664216
申请日：2019-10-25
发明人： Steven STONE , Alexander GUTIN , Susanne WAGNER , Julia REID
IPC分类号： C12Q1/6886 , G16B20/00
摘要： Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.
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