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    PROCESS FOR THE PREPARATION OF POLYSACCHARIDES
    1.
    发明申请
    PROCESS FOR THE PREPARATION OF POLYSACCHARIDES 审中-公开

    公开(公告)号：US20180134813A1

    公开(公告)日：2018-05-17

    申请号：US15570227

    申请日：2016-05-18

    申请人： Chemi S.P.A.

    发明人： Lorenzo De Ferra ,  Ettore Ammirati ,  Simona Andreassi ,  Mauro Annibaldi ,  Luca Mandelli ,  Barbara Pinto ,  Felice Stracqualursi

    IPC分类号： C08B37/00 ,  C07H11/00 ,  A61K31/737

    摘要： The present invention relates to a process for the preparation of a polysaccharide composed of D-xylose units of formula (III) linked together via beta 1,4 glycosidic bonds wherein R1 is hydrogen or acetyl, R2 is hydrogen, acetyl or a 4-O-methyl glucuronic acid unit, wherein, when R2 is a 4-O-methyl glucuronic acid unit, the R1 group on the same saccharide unit is defined as G, wherein G is hydrogen or acetyl, and wherein the sugar unit at the reducing end of sun such polysaccharide is xylose, lyxose or xylulose, said process comprising the following steps: selective deacetylation of xylan extracted from beech wood; and isomerization of the selectively deacetylated xylan achieved in step or the following steps: isomerization of xylan extracted from beech wood; and selective deacetylation of isomerized xylan achieved in step. The process is useful for the preparation of pentosan polysulfate or pharmaceutically acceptable salts thereof for pharmaceutical use.

    Purifying process for phosphatidylserine
    3.
    再颁专利
    Purifying process for phosphatidylserine 有权
    磷脂酰丝氨酸的纯化过程

    公开(公告)号：USRE43764E1

    公开(公告)日：2012-10-23

    申请号：US13167785

    申请日：2011-06-24

    申请人： Lorenzo De Ferra ,  Pietro Massardo

    发明人： Lorenzo De Ferra ,  Pietro Massardo

    IPC分类号： C12P13/06

    CPC分类号： C07F9/103

    摘要： The present invention relates to a purifying process for phosphatidylserine, the latter being prepared by trans-phosphatidylation of phosphatidylcholine with serine in presence of the enzyme D-phospholipase and containing as impurities hydrophilic compounds, proteins and inorganic salts.

    摘要翻译： 本发明涉及一种磷脂酰丝氨酸的纯化方法，后者是通过在酶D-磷脂酶存在下用丝氨酸反磷脂酰化制备的，并含有杂质亲水性化合物，蛋白质和无机盐。

    PROCESS FOR THE PRODUCTION OF N-ACYL-PHOSPHATIDYL-ETHANOLAMINE
    4.
    发明申请
    PROCESS FOR THE PRODUCTION OF N-ACYL-PHOSPHATIDYL-ETHANOLAMINE 有权
    制备N-乙酰基 - 苯乙胺的方法

    公开(公告)号：US20110111469A1

    公开(公告)日：2011-05-12

    申请号：US13002693

    申请日：2008-07-08

    申请人： Lorenzo De Ferra ,  Mauro Anibaldi ,  Ettore Ammirati

    发明人： Lorenzo De Ferra ,  Mauro Anibaldi ,  Ettore Ammirati

    IPC分类号： C12P13/00

    CPC分类号： C07F9/106 ,  C07F9/10

    摘要： The document describes a process for the preparation of N-Acyl-Phosphatidyl-Ethanolamine of formula (I) on an industrial scale, In which R1, R2 and R3 are, independently from each other, saturated, monounsaturated or polyunsaturated acyls C10-C30, pure or mixed together, and X=OH or OM, where M=alkaline metal or alkaline earth, ammonium or alkylammonium. The process in question allows the conversion of lecithin of synthetic or natural origin into N-Acyl-Phosphatidyl-Ethanolamine of formula (I) of high purity, using a limited molar excess of the reagent N-acyl-ethanolamine, where the acyl is as defined above for the formula (I) through reaction of transphosphatidylation in the presence of the enzyme phospholipase D and in conditions suitable for production on an industrial scale.

    摘要翻译： 该文献描述了以工业规模制备式（I）的N-酰基 - 磷酰基 - 乙醇胺的方法，其中R 1，R 2和R 3彼此独立地是饱和的，单不饱和或多不饱和酰基C10-C30， 纯或混合在一起，X = OH或OM，其中M =碱金属或碱土金属，铵或烷基铵。 所讨论的方法允许使用有限摩尔过量的试剂N-酰基 - 乙醇胺将合成或天然来源的卵磷脂转化为高纯度的式（I）的N-酰基 - 磷酰基 - 乙醇胺，其中酰基如 通过在磷脂酶D存在下的磷脂酰化反应和适合于工业规模生产的条件下，通式（I）所定义。

    Solid forms of fesoterodine fumarate
    9.
    发明申请
    Solid forms of fesoterodine fumarate 有权
    富马酸菲索特罗的固体形式

    公开(公告)号：US20100152483A1

    公开(公告)日：2010-06-17

    申请号：US12654123

    申请日：2009-12-10

    申请人： Umberto Ciambecchini ,  Maurizio Zenoni ,  Stefano Turchetta

    发明人： Umberto Ciambecchini ,  Maurizio Zenoni ,  Stefano Turchetta

    IPC分类号： C07C69/02

    CPC分类号： C07C219/28 ,  C07C57/15

    摘要： New solid forms of fesoterodine fumarate are described. In particular, amorphous fesoterodine fumarate, characterised by a powder X-ray diffraction spectrum as shown in FIG. 1 and by an IR spectrum as shown in FIG. 2 is described. Also fesoterodine fumarate in crystalline form I, characterised by a powder X-ray diffraction spectrum as shown in FIG. 3, by a DSC profile as shown in FIG. 4, by an IR spectrum as shown in FIG. 5, by a solid state 13C-NMR spectrum as shown in FIG. 6 and by a Raman spectrum as shown in FIGS. 7, 8 and 9 is described.

    摘要翻译： 描述富马酸非索罗定的新固体形式。 特别是富马酸非索非罗丹，其特征在于如图1所示的粉末X射线衍射光谱。 1和IR光谱如图1所示。 描述图2。 还有结晶形式I的富马酸菲索特罗，其特征在于如图1所示的粉末X射线衍射光谱。 如图3所示，通过如图3所示的DSC轮廓。 如图4所示，通过如图4所示的IR光谱。 如图5所示，通过图13所示的固态13 C-NMR光谱。 如图6所示，通过拉曼光谱。 描述图7,8和9。