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公开(公告)号：US11761019B2
公开(公告)日：2023-09-19
申请号：US16651889
申请日：2018-09-28
申请人： BETHPHAGEN INC.
发明人： Min-Ah Lee , Tae Hwan Kwak , Woo Jin Park
摘要： A pharmaceutical composition suitable for preventing or treating cardiac arrhythmia is disclosed. The pharmaceutical composition contains, as an active ingredient, a CCN5 protein or a nucleotide encoding the CCN5 protein. The pharmaceutical composition inhibits the pathological activity of CaMKII, which induces cardiac electrical abnormalities that is the main cause of atrial arrhythmia and ventricular arrhythmia, so as to restore the electrical functions, and inhibits the activity of myofibroblasts causing structural abnormalities. Therefore, the pharmaceutical composition can be effectively used in the prevention or treatment of cardiac arrhythmia.
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公开(公告)号：US20200263200A1
公开(公告)日：2020-08-20
申请号：US16651889
申请日：2018-09-28
申请人： BETHPHAGEN INC.
发明人： Min-Ah LEE , Tae Hwan KWAK , Woo Jin PARK
摘要： The present invention relates to a pharmaceutical composition for preventing or treating cardiac arrhythmia. Particularly, the present invention relates to a pharmaceutical composition containing, as an active ingredient, a CCN5 protein or a nucleotide encoding the same. The pharmaceutical composition for preventing or treating cardiac arrhythmia, of the present invention, inhibits the pathological activity of CaMKII, which induces cardiac electrical abnormalities which is the main cause of atrial arrhythmia and ventricular arrhythmia, so as to restore the electrical functions, and inhibits the activity of myofibroblasts causing structural abnormalities. Therefore, the pharmaceutical composition of the present invention can be effectively used in the prevention or treatment of cardiac arrhythmia.
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公开(公告)号：US20180369324A1
公开(公告)日：2018-12-27
申请号：US15775553
申请日：2016-11-11
申请人： BETHPHAGEN INC.
发明人： Woo Jin PARK , Min-Ah LEE , Dong Tak JEONG
IPC分类号： A61K38/17 , A61K35/761 , A61P9/00 , C12N15/86
摘要： The present invention relates to a pharmaceutical composition for the treatment of cardiac fibrosis or heart diseases accompanied by cardiac fibrosis. According to the present invention, the composition of the present invention has an effect of dissolving a fibrosis matrix and performing restoration to normal tissues by selectively destroying myofibroblasts in cardiac fibrosis which is diagnosed after a disease occurs, and therefore can be usefully used as a composition for the treatment of cardiac fibrosis, systolic heart failure and diastolic heart failure for which a therapeutic agent has not been developed due to being considered as an irreversible disease progression up to date.
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4.发明授权公开(公告)号：US11426441B2
公开(公告)日：2022-08-30
申请号：US16344467
申请日：2017-10-24
申请人： BethphaGen Inc.
发明人： Woo Jin Park , Seung Pil Jang
摘要： The present invention relates to a composition comprising a protein phosphatase 1 inhibitory peptide for treating vascular diseases. The composition of the present invention inhibits protein phosphatase 1 (PP1)-mediated dephosphorylation to suppress abnormal proliferation of vascular smooth muscle cells (VSMCs), and activates eNOS of vascular endothelial cells (VECs) to induce the recovery from dysfunction, and thus can be favorably used in the treatment of vascular diseases including pulmonary hypertension.
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公开(公告)号：US20200239862A1
公开(公告)日：2020-07-30
申请号：US16651779
申请日：2018-09-28
申请人： BETHPHAGEN INC.
发明人： Tae Hwan KWAK , Woo Jin PARK
摘要： The present invention relates to a pharmaceutical composition for prevention and treatment of heart failure. Specifically, the present invention relates to a gene construct comprising a polynucleotide coding for SERCA2a protein or a fragment thereof and a polynucleotide coding for CCN5 protein or a fragment thereof, and a pharmaceutical composition comprising the same construct as an effective ingredient for preventing or treating heart failure. A pharmaceutical composition for prevention and treatment of heart failure according to the present invention is used in a method for co-expression of SERCA2a protein and CCN5 protein. Designed to exert a synergistic therapeutic effect through SERCA2a protein's function of preventing the loss of cardiomyocytes and increasing the activity of cardiomyocytes and CCN5 protein's function of suppressing the fibrosis of heart cells and tissues, the pharmaceutical composition can be useful for preventing or treating heart failure, which is a complex disorder induced by various etiological factors.
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6.再颁专利公开(公告)号：USRE48636E1
公开(公告)日：2021-07-13
申请号：US16662518
申请日：2019-10-24
申请人： BethphaGen Inc.
发明人： Woo Jin Park , Jae Gyun Oh
摘要： The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: X1-Ala-X2—X3-Ile-Glu-X4 (I). It is noteworthy that the decoy peptide or polypeptide of the present invention significantly elevates phosphorylation levels of PLB by inhibiting PP1-mediated dephosphorylation. In addition, the decoy peptide or polypeptide provides cardio-protective effects by restoring of SERCA2a activity and inotropic effect of enhancing myocardial contractility. The present invention will contribute greatly to the prevention or treatment of diseases associated with PLB.
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7.发明授权公开(公告)号：US10479816B2
公开(公告)日：2019-11-19
申请号：US16224438
申请日：2018-12-18
申请人： BethphaGen Inc.
发明人： Woo Jin Park , Roger J. Hajjar , Jae Gyun Oh
摘要： The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: X1-Ala-X2-X3-Ile-Glu-X4 (I). It is noteworthy that the decoy peptide or polypeptide of the present invention significantly elevates phosphorylation levels of PLB by inhibiting PP1-mediated dephosphorylation. In addition, the decoy peptide or polypeptide provides cardio-protective effects by restoring of SERCA2a activity and inotropic effect of enhancing myocardial contractility. The present invention will contribute greatly to the prevention or treatment of diseases associated with PLB.
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公开(公告)号：US09855315B2
公开(公告)日：2018-01-02
申请号：US13636500
申请日：2011-03-10
申请人： Woo Jin Park , Pyoung Oh Yoon , Dong Kwon Yang
发明人： Woo Jin Park , Pyoung Oh Yoon , Dong Kwon Yang
IPC分类号： A61K48/00 , A61K38/18 , C07K14/475 , G01N33/68 , A61K31/7088 , A61K38/17 , A01K67/027
CPC分类号： A61K38/18 , A01K67/0275 , A61K31/7088 , A61K38/179 , C07K14/475 , C12N2799/022 , G01N33/6893 , G01N2800/325
摘要： The present invention relates to a pharmaceutical composition for preventing or treating a heart failure and a method for screening a therapeutic agent for preventing or treating a heart failure. The pharmaceutical composition of the present disclosure comprises the CCN5 or CCN2ΔCT protein, or a genetic carrier comprising a nucleotide sequence encoding the CCN5 or the CCN2ΔCT protein, exhibiting dramatic prevention or treatment efficacies on a heart failure even without surgical treatments accompanied with transplanting a donor heart.
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