公开(公告)号：US09855315B2

公开(公告)日：2018-01-02

申请号：US13636500

申请日：2011-03-10

申请人： Woo Jin Park ,  Pyoung Oh Yoon ,  Dong Kwon Yang

发明人： Woo Jin Park ,  Pyoung Oh Yoon ,  Dong Kwon Yang

IPC分类号： A61K48/00 ,  A61K38/18 ,  C07K14/475 ,  G01N33/68 ,  A61K31/7088 ,  A61K38/17 ,  A01K67/027

CPC分类号： A61K38/18 ,  A01K67/0275 ,  A61K31/7088 ,  A61K38/179 ,  C07K14/475 ,  C12N2799/022 ,  G01N33/6893 ,  G01N2800/325

摘要： The present invention relates to a pharmaceutical composition for preventing or treating a heart failure and a method for screening a therapeutic agent for preventing or treating a heart failure. The pharmaceutical composition of the present disclosure comprises the CCN5 or CCN2ΔCT protein, or a genetic carrier comprising a nucleotide sequence encoding the CCN5 or the CCN2ΔCT protein, exhibiting dramatic prevention or treatment efficacies on a heart failure even without surgical treatments accompanied with transplanting a donor heart.

公开(公告)号：US20130345130A1

公开(公告)日：2013-12-26

申请号：US13636500

申请日：2011-03-10

申请人： Woo Jin Park ,  Pyoung Oh Yoon ,  Dong Kwon Yang

发明人： Woo Jin Park ,  Pyoung Oh Yoon ,  Dong Kwon Yang

IPC分类号： A61K38/18 ,  A61K31/7088 ,  A61K38/17

CPC分类号： A61K38/18 ,  A01K67/0275 ,  A61K31/7088 ,  A61K38/179 ,  C07K14/475 ,  C12N2799/022 ,  G01N33/6893 ,  G01N2800/325

摘要： The present invention relates to a pharmaceutical composition for preventing or treating a heart failure and a method for screening a therapeutic agent for preventing or treating a heart failure. The pharmaceutical composition of the present disclosure comprises the CCN5 or CCN2ΔCT protein, or a genetic carrier comprising a nucleotide sequence encoding the CCN5 or the CCN2ΔCT protein, exhibiting dramatic prevention or treatment efficacies on a heart failure even without surgical treatments accompanied with transplanting a donor heart.

摘要翻译： 本发明涉及用于预防或治疗心力衰竭的药物组合物和筛选用于预防或治疗心力衰竭的治疗剂的方法。 本公开的药物组合物包含CCN5或CCN2DeltaCT蛋白，或包含编码CCN5或CCN2DeltaCT蛋白的核苷酸序列的遗传载体，即使没有伴随移植供体心脏的外科手术，对心力衰竭也表现出显着的预防或治疗功效 。