SYSTEMS AND METHODS FOR CONTRASTIVE ATTENTION-SUPERVISED TUNING

    公开(公告)号:US20220156592A1

    公开(公告)日:2022-05-19

    申请号:US17209013

    申请日:2021-03-22

    Abstract: Embodiments described herein embodiments described herein provide Contrastive Attention-Supervised Tuning (CAST), a training method to fix the visual grounding ability of contrastive SSL methods based on a data augmentation strategy using unsupervised saliency maps. In addition to the contrastive loss that encourages the model to pick the crop that comes from the corresponding image, CAST provides an explicit grounding supervision through a Grad-CAM based attention loss that enforces models to look at the specified object of interest that is common across different crops when making this decision. A new geometric transform is introduced for randomly cropping different views from an input image based on certain constraints derived from a saliency map.

    Machine-learned hormone status prediction from image analysis

    公开(公告)号:US11508481B2

    公开(公告)日:2022-11-22

    申请号:US16895983

    申请日:2020-06-08

    Abstract: An analytics system uses one or more machine-learned models to predict a hormone receptor status from a H&E stain image. The system partitions H&E stain images each into a plurality of image tiles. Bags of tiles are created through sampling of the image tiles. The analytics system trains one or more machine-learned models with training H&E stain images having a positive or negative receptor status. The analytics system generates, via a tile featurization model, a tile feature vector for each image tile a test bag for a test H&E stain image. The analytics system generates, via an attention model, an aggregate feature vector for the test bag by aggregating the tile feature vectors of the test bag, wherein an attention weight is determined for each tile feature vector. The analytics system predicts a hormone receptor status by applying a prediction model to the aggregate feature vector for the test bag.

    SYSTEMS AND METHODS FOR CONTRASTIVE ATTENTION-SUPERVISED TUNING

    公开(公告)号:US20220156527A1

    公开(公告)日:2022-05-19

    申请号:US17209011

    申请日:2021-03-22

    Abstract: Embodiments described herein embodiments described herein provide Contrastive Attention-Supervised Tuning (CAST), a training method to fix the visual grounding ability of contrastive SSL methods based on a data augmentation strategy using unsupervised saliency maps. In addition to the contrastive loss that encourages the model to pick the crop that comes from the corresponding image, CAST provides an explicit grounding supervision through a Grad-CAM based attention loss that enforces models to look at the specified object of interest that is common across different crops when making this decision. A new geometric transform is introduced for randomly cropping different views from an input image based on certain constraints derived from a saliency map.

    MACHINE-LEARNED HORMONE STATUS PREDICTION FROM IMAGE ANALYSIS

    公开(公告)号:US20210280311A1

    公开(公告)日:2021-09-09

    申请号:US16895983

    申请日:2020-06-08

    Abstract: An analytics system uses one or more machine-learned models to predict a hormone receptor status from a H&E stain image. The system partitions H&E stain images each into a plurality of image tiles. Bags of tiles are created through sampling of the image tiles. The analytics system trains one or more machine-learned models with training H&E stain images having a positive or negative receptor status. The analytics system generates, via a tile featurization model, a tile feature vector for each image tile a test bag for a test H&E stain image. The analytics system generates, via an attention model, an aggregate feature vector for the test bag by aggregating the tile feature vectors of the test bag, wherein an attention weight is determined for each tile feature vector. The analytics system predicts a hormone receptor status by applying a prediction model to the aggregate feature vector for the test bag.

    SYSTEMS AND METHODS FOR LANGUAGE MODELING OF PROTEIN ENGINEERING

    公开(公告)号:US20210249105A1

    公开(公告)日:2021-08-12

    申请号:US17001045

    申请日:2020-08-24

    Abstract: The present disclosure provides systems and methods for controllable protein generation. According to some embodiments, the systems and methods leverage neural network models and techniques that have been developed for other fields, in particular, natural language processing (NLP). In some embodiments, the systems and methods use or employ models implemented with transformer architectures developed for language modeling and apply the same to generative modeling for protein engineering.

    SYSTEMS AND METHODS FOR LANGUAGE MODELING OF PROTEIN ENGINEERING

    公开(公告)号:US20210249100A1

    公开(公告)日:2021-08-12

    申请号:US17001068

    申请日:2020-08-24

    Abstract: The present disclosure provides systems and methods for controllable protein generation. According to some embodiments, the systems and methods leverage neural network models and techniques that have been developed for other fields, in particular, natural language processing (NLP). In some embodiments, the systems and methods use or employ models implemented with transformer architectures developed for language modeling and apply the same to generative modeling for protein engineering.

    SYSTEMS AND METHODS FOR LANGUAGE MODELING OF PROTEIN ENGINEERING

    公开(公告)号:US20210249104A1

    公开(公告)日:2021-08-12

    申请号:US17001090

    申请日:2020-08-24

    Abstract: The present disclosure provides systems and methods for controllable protein generation. According to some embodiments, the systems and methods leverage neural network models and techniques that have been developed for other fields, in particular, natural language processing (NLP). In some embodiments, the systems and methods use or employ models implemented with transformer architectures developed for language modeling and apply the same to generative modeling for protein engineering.

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