公开(公告)号：US20160279304A1

公开(公告)日：2016-09-29

申请号：US15036806

申请日：2014-11-12

申请人： PFM MEDICAL TITANIUM GMBH

发明人： Karin Stadtherr ,  Christof Schmid ,  Karla Lehle ,  Karin Lukas ,  Hanngörg Zimmermann ,  Daniel Wehner ,  Thomas Schmid

IPC分类号： A61L33/00

CPC分类号： A61L33/0029 ,  A61L33/0094 ,  A61L2400/18

摘要： The invention concerns polyurethane (PUR) having an antithrombogenic coating, wherein the antithrombogenic coating comprises at least one antithrombogenic substance covalently bound to a surface of the PUR via at least two bonds, wherein a first of said bonds is an amide bond between the surface of the PUR and a polyethyleneimine (PEI) and a second of said bonds is between the PEI and the antithrombogenic substance, wherein the surface of the PUR had been activated by use of a carbon dioxide plasma or a plasma modified by addition of carbon dioxide before the first of said bonds was formed.

摘要翻译： 本发明涉及具有抗血栓形成包衣的聚氨酯（PUR），其中抗血栓形成包衣包含至少一种通过至少两个键共价结合到PUR表面的抗血栓形成物质，其中第一个所述键是在 PUR和聚乙烯亚胺（PEI）和第二个所述键在PEI和抗血栓形成物质之间，其中PUR的表面已经通过使用二氧化碳等离子体或通过加入二氧化碳改性的血浆进行活化 首先形成债券。

公开(公告)号：US09867912B2

公开(公告)日：2018-01-16

申请号：US15036806

申请日：2014-11-12

申请人： pfm medical titanium gmbh

发明人： Karin Stadtherr ,  Christof Schmid ,  Karla Lehle ,  Karin Lukas ,  Hanngörg Zimmermann ,  Daniel Wehner ,  Thomas Schmid

IPC分类号： A61L33/00

CPC分类号： A61L33/0029 ,  A61L33/0094 ,  A61L2400/18

摘要： The invention concerns polyurethane (PUR) having an antithrombogenic coating, wherein the antithrombogenic coating comprises at least one antithrombogenic substance covalently bound to a surface of the PUR via at least two bonds, wherein a first of said bonds is an amide bond between the surface of the PUR and a polyethyleneimine (PEI) and a second of said bonds is between the PEI and the antithrombogenic substance, wherein the surface of the PUR had been activated by use of a carbon dioxide plasma or a plasma modified by addition of carbon dioxide before the first of said bonds was formed.