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公开(公告)号：US20140199232A1
公开(公告)日：2014-07-17
申请号：US13943074
申请日：2013-07-16
IPC分类号： A61K47/48 , A61K39/44 , A61K38/12 , A61K31/713
CPC分类号： A61K47/4823 , A61K9/06 , A61K31/713 , A61K38/12 , A61K39/44 , A61K45/06 , A61K47/36 , A61K47/48176 , A61K47/48569 , A61K47/48784 , A61K47/48853 , A61K47/48907 , A61K47/48923 , A61K47/58 , A61K47/61 , A61K47/6851 , A61K47/6903 , A61K47/6921 , A61K47/6935 , A61K47/6939 , A61K49/0017 , B82Y5/00 , C08B37/0021 , C08G65/3322 , C08J3/075 , C08J2305/02 , C08L5/02 , C08L63/00 , Y10T428/2982 , C08L5/00
摘要： Disclosure of methods and compositions related to chemical conjugations to nanoparticles of polysaccharides cross-linked to poloxamers as well as nano-sized colloids comprised of polysaccharides and poloxamers. The nanoparticles may be produced by various methods including inverse miniemulsion polymerization processes which create nanogels of desired size, shape, and stability for controlled therapeutic drug delivery, imaging, and theragnostic applications.
摘要翻译： 披露与多价交联到多氯联苯的多糖与由多糖和泊洛沙姆组成的纳米尺寸胶体的化学共轭相关的方法和组合物。 纳米颗粒可以通过各种方法制备，包括反相微乳液聚合方法，其产生所需尺寸，形状和用于受控治疗药物递送，成像和治疗应用的稳定性的纳米凝胶。
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公开(公告)号：US20160106852A1
公开(公告)日：2016-04-21
申请号：US14847213
申请日：2015-09-08
CPC分类号： A61K47/4823 , A61K9/06 , A61K31/713 , A61K38/12 , A61K39/44 , A61K45/06 , A61K47/36 , A61K47/48176 , A61K47/48569 , A61K47/48784 , A61K47/48853 , A61K47/48907 , A61K47/48923 , A61K47/58 , A61K47/61 , A61K47/6851 , A61K47/6903 , A61K47/6921 , A61K47/6935 , A61K47/6939 , A61K49/0017 , B82Y5/00 , C08B37/0021 , C08G65/3322 , C08J3/075 , C08J2305/02 , C08L5/02 , C08L63/00 , Y10T428/2982 , C08L5/00
摘要： Disclosure of methods and compositions related to chemical conjugations to nanoparticles of polysaccharides cross-linked to poloxamers as well as nano-sized colloids comprised of polysaccharides and poloxamers. The nanoparticles may be produced by various methods including inverse miniemulsion polymerization processes which create nanogels of desired size, shape, and stability for controlled therapeutic drug delivery, imaging, and theragnostic applications.
摘要翻译： 披露与多价交联到多氯联苯的多糖与由多糖和泊洛沙姆组成的纳米尺寸胶体的化学共轭相关的方法和组合物。 纳米颗粒可以通过各种方法制备，包括反相微乳液聚合方法，其产生所需尺寸，形状和用于受控治疗药物递送，成像和治疗应用的稳定性的纳米凝胶。
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公开(公告)号：US09161962B2
公开(公告)日：2015-10-20
申请号：US13943074
申请日：2013-07-16
IPC分类号： A61K47/48 , A61K39/44 , A61K38/12 , A61K31/713 , A61K9/06 , A61K47/36 , B82Y5/00 , C08B37/02 , C08J3/075 , C08L5/02 , C08L63/00
CPC分类号： A61K47/4823 , A61K9/06 , A61K31/713 , A61K38/12 , A61K39/44 , A61K45/06 , A61K47/36 , A61K47/48176 , A61K47/48569 , A61K47/48784 , A61K47/48853 , A61K47/48907 , A61K47/48923 , A61K47/58 , A61K47/61 , A61K47/6851 , A61K47/6903 , A61K47/6921 , A61K47/6935 , A61K47/6939 , A61K49/0017 , B82Y5/00 , C08B37/0021 , C08G65/3322 , C08J3/075 , C08J2305/02 , C08L5/02 , C08L63/00 , Y10T428/2982 , C08L5/00
摘要： Disclosure of methods and compositions related to chemical conjugations to nanoparticles of polysaccharides cross-linked to poloxamers as well as nano-sized colloids comprised of polysaccharides and poloxamers. The nanoparticles may be produced by various methods including inverse miniemulsion polymerization processes which create nanogels of desired size, shape, and stability for controlled therapeutic drug delivery, imaging, and theragnostic applications.
摘要翻译： 披露与多价交联到多氯联苯的多糖与由多糖和泊洛沙姆组成的纳米尺寸胶体的化学共轭相关的方法和组合物。 纳米颗粒可以通过各种方法制备，包括反相微乳液聚合方法，其产生所需尺寸，形状和用于受控治疗药物递送，成像和治疗应用的稳定性的纳米凝胶。
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公开(公告)号：US10799600B1
公开(公告)日：2020-10-13
申请号：US16383940
申请日：2019-04-15
IPC分类号： A61K47/69 , A61K47/61 , A61K39/44 , A61K38/12 , C08G65/332 , A61K49/00 , A61K45/06 , A61K31/713 , A61K9/06 , C08L63/00 , C08L5/02 , C08J3/075 , C08B37/02 , B82Y5/00 , A61K47/36 , C08L5/00 , A61K47/58 , A61K47/68 , A61K31/196 , A61K31/405 , A61K31/616 , C07K16/28 , A61K31/58 , A61K31/192
摘要： The invention in the various aspects provides nanogel compositions that are safe for topical, local, and/or systemic delivery, and which can be targeted to select tissues or cells, including pathogens. In some embodiments, conjugation of antibiotics to the nanogel surface, and in particular antibiotics that disrupt outer membranes of Gram negative bacteria or antibiotics that inhibit cell wall synthesis, provide for highly effective targeting and killing of bacterial pathogens, including drug-resistant bacteria.
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公开(公告)号：US20180028684A1
公开(公告)日：2018-02-01
申请号：US15627530
申请日：2017-06-20
IPC分类号： C08L63/00 , C08L5/00 , C08J3/075 , C08G65/332 , C08B37/02 , A61K9/06 , A61K49/00 , A61K47/36 , A61K45/06 , A61K39/44 , A61K38/12 , A61K31/713 , C08L5/02 , B82Y5/00
CPC分类号： A61K47/6931 , A61K9/06 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/58 , A61K31/616 , A61K31/713 , A61K38/12 , A61K39/44 , A61K45/06 , A61K47/36 , A61K47/58 , A61K47/61 , A61K47/6851 , A61K47/6933 , A61K47/6935 , A61K47/6939 , A61K49/0017 , B82Y5/00 , C07K16/2863 , C08B37/0021 , C08G65/3322 , C08J3/075 , C08J2305/02 , C08L5/00 , C08L5/02 , C08L63/00 , Y10T428/2982 , A61K2300/00
摘要： The invention in the various aspects provides nanogel compositions that are safe for topical, local, and/or systemic delivery, and which can be targeted to select tissues or cells, including pathogens. In some embodiments, conjugation of antibiotics to the nanogel surface, and in particular antibiotics that disrupt outer membranes of Gram negative bacteria or antibiotics that inhibit cell wall synthesis, provide for highly effective targeting and killing of bacterial pathogens, including drug-resistant bacteria.
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公开(公告)号：US09694085B2
公开(公告)日：2017-07-04
申请号：US14847213
申请日：2015-09-08
IPC分类号： A61K47/48 , A61K31/713 , A61K39/44 , A61K49/00 , A61K38/12 , A61K45/06 , A61K9/06 , A61K47/36 , B82Y5/00 , C08B37/02 , C08J3/075 , C08L5/02 , C08L63/00 , C08G65/332
CPC分类号： A61K47/4823 , A61K9/06 , A61K31/713 , A61K38/12 , A61K39/44 , A61K45/06 , A61K47/36 , A61K47/48176 , A61K47/48569 , A61K47/48784 , A61K47/48853 , A61K47/48907 , A61K47/48923 , A61K47/58 , A61K47/61 , A61K47/6851 , A61K47/6903 , A61K47/6921 , A61K47/6935 , A61K47/6939 , A61K49/0017 , B82Y5/00 , C08B37/0021 , C08G65/3322 , C08J3/075 , C08J2305/02 , C08L5/02 , C08L63/00 , Y10T428/2982 , C08L5/00
摘要： Disclosure of methods and compositions related to chemical conjugations to nanoparticles of polysaccharides cross-linked to poloxamers as well as nano-sized colloids comprised of polysaccharides and poloxamers. The nanoparticles may be produced by various methods including inverse miniemulsion polymerization processes which create nanogels of desired size, shape, and stability for controlled therapeutic drug delivery, imaging, and theragnostic applications.
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