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公开(公告)号：US20180346584A1
公开(公告)日：2018-12-06
申请号：US16100485
申请日：2018-08-10
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph Leon Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
IPC分类号： C07K16/28 , C07K14/52 , C07K14/715
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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公开(公告)号：US20170320931A1
公开(公告)日：2017-11-09
申请号：US15648203
申请日：2017-07-12
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
IPC分类号： C07K14/715 , C07K14/52 , C07K16/28 , A61K38/00
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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公开(公告)号：US20150010946A1
公开(公告)日：2015-01-08
申请号：US14296488
申请日：2014-06-05
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Jane A. Gross , Angela K. Hammond
IPC分类号： C07K16/24
CPC分类号： C07K16/24 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/52 , C07K2317/24
摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 本发明涉及zcytor17lig多核苷酸，多肽和抗zcytor17抗体分子。 zcytor17lig是一种新型细胞因子。 多肽可用于刺激免疫系统的方法，体外和体内造血细胞的增殖和/或发育。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US20140141485A1
公开(公告)日：2014-05-22
申请号：US14138199
申请日：2013-12-23
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
IPC分类号： C07K14/715
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。
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公开(公告)号：US20180155418A1
公开(公告)日：2018-06-07
申请号：US15429750
申请日：2017-02-10
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Jane A. Gross , Angela K. Hammond
CPC分类号： C07K16/24 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/52 , C07K2317/24
摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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公开(公告)号：US20170204190A1
公开(公告)日：2017-07-20
申请号：US15476006
申请日：2017-03-31
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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公开(公告)号：US20190338020A1
公开(公告)日：2019-11-07
申请号：US16144289
申请日：2018-09-27
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Jane A. Gross , Angela K. Hammond
摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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公开(公告)号：US20160060323A1
公开(公告)日：2016-03-03
申请号：US14937919
申请日：2015-11-11
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
IPC分类号： C07K14/715
CPC分类号： C07K14/715 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K16/2866 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。
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公开(公告)号：US20160002340A1
公开(公告)日：2016-01-07
申请号：US14856588
申请日：2015-09-17
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。
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公开(公告)号：US09212213B2
公开(公告)日：2015-12-15
申请号：US14138199
申请日：2013-12-23
申请人： ZymoGenetics, Inc.
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Theodore E. Whitmore , Angela K. Hammond , Julia E. Novak , Jane A. Gross , Stacey R. Dillon
IPC分类号： C07K14/715 , C07K14/52 , A61K38/00
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。
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