公开(公告)号：US20240308973A1

公开(公告)日：2024-09-19

申请号：US18598312

申请日：2024-03-07

Applicant: Zoetis Services LLC

Inventor： Richard A. EWIN ,  Michael P. CURTIS ,  Todd M. MADDUX ,  Graham M. KYNE

IPC: C07D401/04 ,  A61K31/433 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/501 ,  A61K31/506 ,  A61K31/549 ,  A61K31/55 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D401/04 ,  A61K31/433 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/501 ,  A61K31/506 ,  A61K31/549 ,  A61K31/55 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

Abstract: The invention describes novel PDE3 inhibitors for treating a cardiovascular disease including myxomatous mitral valve disease, congestive heart failure and/or asymptomatic heart failure in animals, particularly canines.

公开(公告)号：US20200031822A1

公开(公告)日：2020-01-30

申请号：US15735686

申请日：2016-06-10

Applicant: ZOETIS SERVICES LLC

Inventor： Govindan SUBRAMANIAN ,  Michael P. CURTIS ,  Jinxia (Nancy) DENG ,  Richard Andrew EWIN ,  Christopher Scott KNAUER ,  Graham M. KYNE ,  Tomasz RESPONDEK ,  Susan Mary Kult SHEEHAN ,  John Adam WENDT

IPC: C07D471/04 ,  A01N47/38

Abstract: The present invention provides Formula (1) compounds that are gamma-carbolines, Formula (1) wherein R1 a, R1 b, R1 c, R1d, R2, R3, and “-” are as defined herein; veterinary acceptable salts thereof, and stereoisomers thereof, which act as parasiticides, in particular, endoperasiticides.