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公开(公告)号：US11236137B2
公开(公告)日：2022-02-01
申请号：US16456218
申请日：2019-06-28
发明人： Bruce Yong Ma , Yu Fan , Jun Wang , Anliang Wang
IPC分类号： C07K14/435 , A61K39/35 , C12N15/81
摘要： Provided are an optimized Der f2 gene, a recombinant Der f2 protein encoded thereby, a vector comprising said gene, and a Pichia pastoris strain. Also provided are an expression method, a purification method, and an application of the recombinant Der f2 protein.
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2.发明申请公开(公告)号：US20190389918A1
公开(公告)日：2019-12-26
申请号：US16456218
申请日：2019-06-28
发明人： Bruce Yong Ma , Yu Fan , Jun Wang , Anliang Wang
IPC分类号： C07K14/435 , C12N15/81 , A61K39/35
摘要： Provided are an optimized Der f2 gene, a recombinant Der f2 protein encoded thereby, a vector comprising said gene, and a Pichia pastoris strain. Also provided are an expression method, a purification method, and an application of the recombinant Der f2 protein.
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公开(公告)号：US11319353B2
公开(公告)日：2022-05-03
申请号：US16474217
申请日：2017-12-28
发明人： Bruce Yong Ma , Yu Fan , Anliang Wang , Jun Wang
IPC分类号： C07K14/435 , A61P37/08 , A61K39/35 , C12N15/81
摘要： A DNA sequence encoding Der p2 protein having a particular base sequence is codon-optimized for the Pichia pastoris expression system, which is conducive to expressing Der p2 in Pichia pastoris. After gene optimization and adding an activating element to increase the expression of Der p2 in molecular level, it was found that Der p2 is expressed at a higher level as compared with the prior art and has biological activity similar to the natural protein.
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公开(公告)号：US10975128B2
公开(公告)日：2021-04-13
申请号：US16456357
申请日：2019-06-28
发明人： Bruce Yong Ma , Yu Fan , Jun Wang , Anliang Wang
IPC分类号： C07K14/435 , A61K38/00
摘要： Provided are an optimized proDer f1 gene, a proDer f1 protein encoded thereby, a vector comprising said gene, and a Pichia pastoris strain. Also provided are an expression method and a purification method of the proDer f1 protein.
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公开(公告)号：US11359191B2
公开(公告)日：2022-06-14
申请号：US16474240
申请日：2017-12-28
发明人： Bruce Yong Ma , Yu Fan , Anliang Wang , Jun Wang
摘要： A DNA sequence encoding Der p1 protein having a particular base sequence is codon-optimized for the Pichia pastoris expression system, which is conducive to expressing Der p1 in Pichia pastoris. After gene optimization and adding an activating element to increase the expression of Der p1 in molecular level, it was found that Der p1 is expressed at a higher level as compared with the prior art and has biological activity similar to the natural protein.
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6.发明授权公开(公告)号：US10752686B2
公开(公告)日：2020-08-25
申请号：US15554476
申请日：2015-10-30
发明人： Yong Ma , Peipei Cao , Anliang Wang
IPC分类号： A61K39/395 , C07K16/30 , C07K16/28 , C07K16/46 , A61P35/00
摘要： Described is a bispecific antibody, and a method for producing the bispecific antibody. The bispecific antibody can be used in the preparation of a drug for treating a tumor with high cell expression of CD26. The antibody specifically hinds to human CD26 and human CD3 at the same time.
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7.发明申请公开(公告)号：US20190389919A1
公开(公告)日：2019-12-26
申请号：US16456357
申请日：2019-06-28
发明人： Bruce Yong Ma , Yu Fan , Jun Wang , Anliang Wang
IPC分类号： C07K14/435
摘要： Provided are an optimized proDer f1 gene, a proDer f1 protein encoded thereby, a vector comprising said gene, and a Pichia pastoris strain. Also provided are an expression method and a purification method of the proDer f1 protein.
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