公开(公告)号：US20240424142A1

公开(公告)日：2024-12-26

申请号：US18689161

申请日：2022-09-07

Applicant: Yale University

Inventor： Jaime GRUTZENDLER ,  Peng YUAN ,  Mengyang ZHANG ,  Lei TONG

IPC: A61K48/00 ,  A61P25/28 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

Abstract: Described herein is a method of reversing or preventing a formation or enlargement of an axonal spheroid. The method includes introducing into a neuron affected by formation or enlargement of the axonal spheroid a compound that downregulates PLD3 expression level or activity. Also described herein is a method of treating or preventing a neurodegenerative condition in a subject in need thereof. The method includes administering to the subject a compound that downregulates PLD3 expression level or activity in a neuron cell affected by the neurodegenerative condition. Further described herein is a pharmaceutical composition for treating a neurodegenerative condition in a subject. The pharmaceutical composition includes a compound that downregulates PDL3 expression level or activity in a neuron cell affected by the neurodegenerative condition; and a pharmaceutically acceptable carrier.